夏赞贤
简介
1998年于中国科学院上海生物化学与细胞生物学研究所获得博士学位，随后在美国加州理工学院（Caltech）、南加州大学（USC）和一家生物制药公司以博士后和高级科学家等身份从事泛素系统的结构功能、WNT/β-catenin信号途径的蛋白质组学、蛋白抗体药物的筛选以及对多种实体瘤的治疗应用的机制研究。
在PNAS, Molecular and Cellular Biology, Journal of Biological Chemistry, Journal of Proteomics, Proteomics，Journal of Molecular Cell Biology，The Journal of Nuclear Medicine，PLoS ONE等国际学术期刊发表20多篇研究论文，引用总次数超过300次。
研究方向：
1. 肿瘤、肿瘤细胞和肿瘤干细胞的蛋白质泛素化的蛋白质组学研究 2. WNT/β-catenin信号途径与多药耐药（MDR）的调控机制 3. 靶向EphB4-EphrinB2信号途径的肿瘤治疗策略
代表论文
1.HongMa,MingquanGuo,BaoenShan,andZanxianXia*(2012)Targetedfunctionalanalysisofp300coactivatorinWnt/β-cateninsignalingpathwayusingphosphoproteomicandbiochemicalapproaches.JournalofProteomics,75(9):2601-10(“*”,通讯作者)
2.ZanxianXia#,MingquanGuo#,andHongMa(2011)FunctionalanalysisofnovelphosphorylationsitesofCREB-bindingproteinusingmassspectrometryandmammaliantwo-hybridassays.Proteomics,11(17):3444-51(“#”,并列第一作者)
3.XiaohuiZhou#,ZanxianXia#,QinLan,JulieWang,WenruSu,Yuan-PingHan,ZhongminLiu,WilliamStohl,andSongGuoZheng(2011)BAFFpromotesTh17cellsandaggravatesTh17cell-mediatedautoimmunity.PLoSONE,6(8):e23629(“#”,并列第一作者)
4.MingquanGuo#,ZanxianXia#,andHongMa(2011)Functionalphosphositescreeningfortargetedprotein-proteininteractionsbycombiningphosphoproteomicsstrategiesandmammaliantwo-hybridassays.MolBiosyst,7(6):1838-41(“#”,并列第一作者)
5.YujiroKida,ZanxianXia,SujunZheng,NicholasM.Mordwinkin,StanG.Louie,SongGuoZheng,MinFeng,HongboShi,ZhongpingDuan,andYuan-PingHan(2011)Interleukin-1isaninjurysignalcontrollingimmobilizationofretinylestersinhepaticstellatecellsthroughdownregulationoflecithinretinolacyltransferase.PLoSOne,6(11):e26644
6.ZanxianXia,AilsaWebster,FangyongDu,KonstantinPiatkov,MichelGhislain,andAlexanderVarshavsky(2008)Substrate-bindingsitesofUBR1,theubiquitinligaseoftheN-endrulepathway.JBiolChem,283(35):24011-24028
7.ZanxianXia,GlennC.Turner,Cheol-SangHwang,ChristopherByrd,andAlexanderVarshavsky(2008)AminoacidsinducepeptideuptakeviaaccelerateddegradationofCUP9,thetranscriptionalrepressorofthePTR2peptidetransporter.JBiolChem,283(43):28958-68
8.Rong-GuiHu,HaiqingWang,ZanxianXia,andAlexanderVarshavsky(2008)TheN-endrulepathwayisasensorofheme.ProcNatlAcadSciUSA,105(1):76-81。