張俊傑
人物簡歷
1988-1992，復旦大學生命科學院微生物系，本科生；1992-1995，北京生物製品研究所醫學免疫學專業，碩士研究生；1995-1998，第四軍醫大學生物化學與分子生物學專業，博士研究生；1998-2000，第四軍醫大學生物化學與分子生物學教研室，講師；2000-2004，美國新澤西醫科和牙科大學Robert Wood Johnson醫學院，博士後；2004-2005，北京生命科學研究所，博士後；2005-今，北京師範大學生命科學學院，教授。2005年入選北京市科技新星計劃和教育部新世紀優秀人才支持計劃；2006-2009年任細胞生物學系系主任；2009-2022年任細胞生物學研究所所長、細胞增殖及調控生物學教育部重點實驗室主任；2021年4月至今任生物學系系主任。擔任北京細胞生物學會理事，中國生物化學與分子生物學會脂質與脂蛋白專業委員會委員。主持的本科生《分子生物學》雙語課程被評為國家雙語示範課程和國家精品課程。在Molecular Cell，Autophagy，Journal of Biological Chemistry，Journal of Lipid Research等學術刊物上發表SCI論文36篇，授權國家發明專利6項。
研究內容
生物活性脂質分子LPA的代謝調控及其生理和病理意義：重點研究LPA生成關鍵酶Autotaxin(ATX)的表達調控機制，闡釋ATX-LPA-LPA受體通路在免疫調控、腫瘤發生以及肥胖相關疾病中的作用。
應激條件下腫瘤細胞的生長調控機制：重點研究在缺氧、營養缺乏、DNA損傷等應激條件下，腫瘤細胞增殖、自噬和凋亡的調控機制。
應激條件下細菌的生長調控機制：研究毒素-抗毒素系統(Toxin-antitoxin system)和Pup-蛋白酶體系統在分枝桿菌生長調控中的作用及其分子機制，揭示相關機制在結核分枝桿菌致病中的作用，探討結核病防治的新方法。
研究成果
論文
1. Mengmiao Li, Qian Huang, Weidi Zhang, Yinghua Cao, Zhanxin Wang, Zhenwen Zhao, Xiaotian Zhang and Junjie Zhang* (2022). A Novel Acyl-AcpM-Binding Protein Confers Intrinsic Sensitivity to Fatty Acid Synthase Type II Inhibitors in Mycobacterium smegmatis. Frontiers in Microbiology, 13:846722. doi: 10.3389/fmicb.2022.846722.
2. Xin Xu, Yihua Zhang, Junjie Zhang*, and Xiaotian Zhang* (2020). NSun2 promotes cell migration through methylating autotaxin mRNA. Journal of Biological Chemistry，295 (52),18134-18147.
3. Yuqin Wang, Lin Lvy, Xiaotian Zhang*, and Junjie Zhang* (2019). Autotaxin is a novel target of microRNA-101-3p. FEBS Open Bio. 9(4):707-716.
4. Xiaodong Chi, Yunqing Chang, Mengmiao Li, Jin Lin, Yi Liu, Chuanyou Li, Shenjie Tang and Junjie Zhang*(2018). Biochemical characterization of mt-PemIK, a novel toxin-antitoxin system in Mycobacterium tuberculosis. FEBS Letters 592(24):4039-4050.
5. Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhanwen Zhao, Junjie Zhang* (2017). Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Journal of Lipid Research 58(11):2102-2113. (Cover story)
6. Lin Lyu, Baolu Wang, Chaoyang Xiong, Xiaotian Zhang, Xiaoyan Zhang, and Junjie Zhang* (2017). Selective export of autotaxin from the endoplasmic reticulum. Journal of Biological Chemistry 292(17):7011-7022.
7. Shuhong Sun, Xiaotian Zhang*, Lin Lyu, Xixi Li, Siliang Yao, and Junjie Zhang* (2016). Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1. Journal of Biological Chemistry 291(50):25823-25836.
8. Xuejie Chen, Chandan Li, Li Wang, Yi Liu, Chuanyou Li, Junjie Zhang* (2016) The Mechanism of Mycobacterium smegmatis PafA Self-Pupylation. PLoS ONE 11(3): e0151021. doi:10.1371/journal.pone.0151021.
9. Jianwen Song, Ming Guan, Zhenwen Zhao, Junjie Zhang* (2015) Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation. PLoS ONE 10(8): e0136629. doi:10.1371/journal.pone.0136629.
10. Song Li, Bin Guo, Jianwen Song, Xiaoli Deng, Yusheng Cong, Pengfei Li, Ke Zhao, Lihong Liu, Gang Xiao, Feng Xu, Yingjiang Ye, Zhenwen Zhao, Menggang Yu, Yan Xu, Jianli Sang*, Junjie Zhang* (2013). Plasma choline-containing phospholipids: Potential biomarkers for colorectal cancer progression. Metabolomics 9(1):202-212.
11. Xiaolei Xie, Li Le, Yanxin Fan, Lin Lv, Junjie Zhang* (2012). Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition. Autophagy 8(7): 1071-1084.
12. Song Li, Chaoyang Xiong, Junjie Zhang* (2012). ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways. FEBS Letter 586(6):792-797.
13. Song Li, Baolu Wang, Yan Xu, Junjie Zhang* (2011). Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis. Molecular Cancer 10(1):18 doi:10.1186/1476-4598-10-18.
14. Song Li, Junjie Zhang* (2009) Lipopolysaccharide Induces Autotaxin Expression in Monocytic THP-1 Cells. Biochemical and Biophysical Research Communications 378(2):264-268.
15. Longxuan Zhao, Junjie Zhang* (2008) Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis. FEBS Letter 582(5)710-714.
16. Motoo Suzuki, Junjie Zhang, Mohan Liu, Nancy A. Woychik and Massayori Inouye* (2005). Single protein production in living cells facilitated by an mRNA interferase. Molecular Cell 18(2):253-261.
17. Junjie Zhang, Yonglong Zhang, Ling Zhu, Motoo Suzuki and Masayori Inouye* (2004). Interference of mRNA function by sequence-specific endoribonuclease PemK. Journal of Biological Chemistry 279(20):20678-20684.
18. Yonglong Zhang#, Junjie Zhang#, Klaus P. Hoeflich, Mitsuhiko Ikura, Guoliang Qing, Masayori Inouye* (2003). MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli. Molecular Cell 12(4):913-923. (#Authors contributed equally).
19. Junjie Zhang, Yonglong Zhang and Masayori Inouye* (2003). Characterization of the interactions within the mazEF addiction module of Escherichia coli. Journal of Biological Chemistry 278(34):32300-32306.
20. Junjie Zhang, Yonglong Zhang and Masayori Inouye* (2003). Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activity. Journal of Biological Chemistry 278(24): 21408-21414.
21. Junjie Zhang, Masayori Inouye* (2002). MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. Journal of Bacteriology 184(19): 5323-5329.
綜述
22. 張地，張俊傑*（2022）.Autotaxin表達調控機制及其生物學功能. 中國科學：生命科學，52（8），1148-1162.
23. Xiaotian Zhang, Mengmiao Li, Nan Yin, Junjie Zhang* (2021). The Expression Regulation and Biological Function of Autotaxin. Cells, 10(4):939. doi:10.3390/cells10040939
24. 尹楠，張俊傑*（2021）. Autotaxin-LPA軸在肥胖及其相關疾病中的作用. 生物化學與生物物理進展 48（7）, 768-778.
25. 汪春軍，林進，張俊傑* (2011). 原核生物類泛素蛋白Pup-蛋白酶體系統的研究進展. 生物化學與生物物理進展 38（12）：1091-1098.
26. 王曉蕾，趙龍旋，張俊傑*（2008）. 細菌毒素-抗毒素系統的研究進展. 生物化學與生物物理進展 35（9）：991-997.[1]