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郭宇轩，男，北京大学基础医学院研究员。
人物履历
2006.9-2010.7 北京大学生命科学学院 本科
2010.8-2015.8 约翰霍普金斯大学生物系 博士 （导师：Yixian Zheng,PhD）
2015.8-2020.11 波士顿儿童医院/哈佛医学院博士后 （导师：William Pu,MD）
2020.11-今 北京大学基础医学院/北京大学心血管研究所 研究员
课题方向
经费与奖励
1. 2022-2025，国家自然科学基金，面上项目
2. 2022-2024，国家自然科学基金，青年科学基金项目
3. 2021-2024，北京市科技新星
4. 2020 NIH Pathway to Independence Award (K99)
学术成果
1. Yang L, Sun J, Chen Z, Liu L, Sun Y, Lin J, Hu X, Zhao M, Ma Y, Lu D, Li Y#, Guo Y#, Dong E. The LMNA p.R541C mutation causes dilated cardiomyopathy in human and mice. Int J Cardiol. 2022
2. Lin J, Chen Z, Yang L, Liu L, Yue P, Sun Y, Zhao M, Guo X, Hu X, Zhang Y, Zhang H, Li Y, Guo Y#, Dong E. Cas9/AAV9-Mediated Somatic Mutagenesis Uncovered the Cell-Autonomous Role of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2 in Murine Cardiomyocyte Maturation. Front Cell Dev Biol. 2022 Apr 1;10:864516
3. Guo Y*#, Cao Y*, Jardin BD*, Zhang X, Zhou P, Guatimosim S, Lin J, Chen Z, Zhang Y, Mazumdar N, Lu F, Ma Q, Lu YW, Zhao M, Wang DZ, Dong E, Pu WT#. Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation. Cardiovasc Res. 2022, May 16;cvac077.
4. Guo Y*#, Cao Y*, Jardin BD*, Sethi I, Ma Q, Moghadaszadeh B, Troiano EC, Mazumdar N, Trembley MA, Small EM, Yuan GC, Beggs AH, and Pu WT#, Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. PNAS . 2021, Jan..
5. Guo Y, Pu WT, Cardiomyocyte Maturation: New Phase in Development. Circ Res . 2020, Apr 10;126(8):1086-1106.
6. Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT, Hierarchical and stage-specific regulation of cardiomyocyte maturation by serum response factor. Nat Commun . 2018 Sep 21;9(1):3837.
7. Guo Y, Pu WT, Genetic Mosaics for Greater Precision in Cardiovascular Research. Circ Res. 2018 Jun 22;123(1):27-29.
8. Guo Y*, VanDusen NJ*, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT, Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 9;120(12):1874-1888.
9. Guo Y, Zheng Y, Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell. 2015 Oct 1;26(19):3379-89.
10. Guo Y, Kim Y, Shimi T, Goldman RD, Zheng Y, Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins. Mol Biol Cell. 2014 Apr;25(8):1287-97.(Highlighted in MBoC)[1]