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Engin umut Akkaya,男，毕业于The Ohio State University，博士，大连理工大学硕士生导师。土耳其科学院院士，英国皇家化学会会士，辽宁省“兴辽英才计划”创新领军人才，辽宁省“外专百人”，大连理工大学“星海学者”。 [1]
个人简介
1991年获得俄亥俄州立大学化学博士学位，随后在俄亥俄州立大学医学院和马里兰大学从事博士后研究工作。1995年在土耳其Middle East Technical University开始了他的独立研究，2003年晋升为全职教授。2007年任土耳其Bilkent University教授。2018年，作为国际化高端科技人才，加入大连理工大学精细化学国家重点实验室与化工学院药学系。曾获得多个国家奖项，包括Parlar基金会，TUBITAK（2009）和TUSEB（2017）的最高荣誉，以及Czarnik，EWHA Lectureship等国际奖。其研究成果多次发表于Nat. Commun.; J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Adv. Funct. Mater. 等国际著名期刊，并多次被邀请在国际会议上作大会报告。
工作经历
2018.8至今 大连理工大学
2007.1-2018.1 Bilkent UniversityProfessor
1995.1-2007.1 Middle East Technical UniversityProfessor
1991.1-1994.12 University of Maryland School of MedicinePostdoc
1989.1-1991.1 The Ohio State University,USAPostdoc
教育经历
1986.1-1989.1 The Ohio State UniversityChemistry博士
1984.1-1986.1 The Ohio State UniversityChemistry硕士
1980.1-1983.1 Middle East Technical UniversityChemistry学士
研究方向
1. 光动力治疗癌症
2. 分子探针在疾病诊断和治疗中的应用
3. 内过氧类抗癌制剂的设计及抗癌研究
4. 分子逻辑门和分子器件，信息处理性治疗药
代表性成果
Ucar, E.; Xi, D.; Seven, O., Kaya, C.; Peng, X. J., Sun, W., Akkaya, E. U.*“Off-On” Switching of Intracellular Singlet Oxygen Release Under Biocompatible Conditions”, Chem. Commun. 2019,DOI 10.1039/c9cc06231a
Turan, I. S., Gunaydin, G., Ayan, S., Akkaya, E. U.*“Molecular Demultiplexer as a Terminator Automaton" Nat. Commun. 2018, 9, 805.
Erbas-Cakmak, S., Kolemen, S., Sedgwick, A. C., Gunnlaugsson, T., James, T. D., Yoon, J., Akkaya, E. U.*“Molecular Logic gates: the past, present and future” Chem. Soc. Rev. 2017, 47, 2228.
Li, X., Kolemen, S., Yoon, J. and Akkaya, E. U. “Activatable Photosensitizers: Agents for Selective Photodynamic Therapy", Adv. Funct. Mater., 2017, 27, 1604053.
Kolemen, S.; Ozdemir, T.; Lee, D. Kim, G. M.; Karatas, T.; Yoon, J.; Akkaya, E. U.*“Remote Controlled Release of Singlet Oxygen by the Plasmonic Heating of Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy", Angew. Chem. Int. Ed. 2016, 55, 3606.
Turan, I. S.; Yildiz, D.; Turksoy, A.; Gunaydin, G.; Akkaya, E. U.*“A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light” Angew. Chem. Int. Ed. 2016, 55, 2875.
Kölemen, S.; Işık, M.; Kim, G. M.; Kim, D.; Geng, H.; Buyuktemiz, M; Karatas,T.; Zhang, X.-F.; Dede, Y.; Yoon, J.; Akkaya, E. U.* "Intracellular Modulation of Excited State Dynamics in a Chromophore Dyad: Differential Enhancement of Photocytotoxicity Targeting Cancer Cells" Angew. Chem. Int. Ed., 2015, 54, 5340.
A. Atılgan, E. T. Eçik, R. Guliyev, T. B. Uyar, S. Erbaş-Çakmak, E.U. Akkaya,* "Near-IR Triggered, Remote-Controlled Release of Metal Ions: A Novel Strategy for Caged Ions," Angew. Chem.Int. Ed., 2014, 53, 10678.
Erbas-Cakmak, S.; Akkaya, E.U.*“Cascading of Molecular Logic Gates for Advanced Functions: A Self-Reporting, Activatable Photosensitizer”Angew. Chem. Int. Ed. 2013, 52, 11364.
Erbas-Cakmak, S.; Bozdemir, O.A.; Cakmak, Y.; Akkaya, E.U.* “Proof of principle for a molecular 1:2 demultiplexer to function as an autonomously switching theranostic device” Chem. Sci. 2013, 4, 858.
Cakmak, Y.; Kolemen, S.; Duman, S.; Dede, Y.; Dolen, Y.; Kilic, B.; Kostereli, Z.; Yildirim, L. T.; Dogan, A. L.; Guc, D.; Akkaya, E. U.* Designing Excited States: Theory-Guided Access to Efficient Photosensitizers for Photodynamic Action, Angew. Chem. Int. Ed. 2011, 50, 11937.
Bozdemir, O. A.; Erbas-Cakmak, S.; Ekiz, O. O.; Dana, A.; Akkaya, E. U.* Towards Unimolecular Luminescent Solar Concentrators: Bodipy-based Dendritic Energy-Transfer Cascade with Panchromatic Absorption and Monochromatized Emission, Angew. Chem. Int. Ed. 2011, 50, 10907.
Guliyev, R.; Ozturk, S. Kostereli, Z.; Akkaya, E. U.* From Virtual to Physical: Integration of Chemical Logic Gates, Angew. Chem. Int. Ed. 2011, 50, 9826.
Kolemen, S.; Bozdemir, O. A.; Cakmak, Y.; Barin, G.; Erten-Ela, S.; Marszalek, M.; Yum, J. H.; Zakeeruddin, S. M.; Nazeeruddin, M. K.; Gratzel, M.; Akkaya, E. U.,* Optimization of distyryl-Bodipy chromophores for efficient panchromatic sensitization in dye sensitized solar cells, Chem. Sci. 2011, 2, 949.
Bozdemir, O. A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E. U.* Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Simultaneous Sensing of Multiple Metal Ions. J. Am. Chem. Soc. 2010, 132, 8029.
Guliyev, R.; Coskun, A.; Akkaya, E. U.* Design Strategies for Ratiometric Chemosensors: Modulation of Excitation Energy Transfer at the Energy Donor Site, J. Am. Chem. Soc. 2009, 131, 9007.
Ozlem, S.; Akkaya, E. U.* Thinking Outside the Silicon Box: Molecular AND Logic As an Additional Layer of Selectivity in Singlet Oxygen Generation for Photodynamic Therapy, J. Am. Chem. Soc. 2009, 131, 48.
Coskun, A; Akkaya, E.U.* Signal Ratio Amplification via Modulation of Resonance Energy Transfer: Proof of Principle in an Emission Ratiometric Hg(II) Sensor, J. Am. Chem. Soc. 2006, 128, 14474.
Coskun, A.; Akkaya, E. U.* Ion Sensing Coupled to Resonance Energy Transfer: A Highly Selective and Sensitive Ratiometric Fluorescent Chemosensor for Ag(I) by a Modular Approach, J. Am. Chem. Soc. 2005, 127, 10464.
Akkaya, E.U., Huston, M.E.; Czarnik, A.W. Chelation Enhanced Fluorescence of Anthrylazamacrocycle Conjugate Probes in Aqueous Solutions, J. Am. Chem. Soc., 1990, 112, 3590.
Huston, M.E.; Akkaya, E.U.; Czarnik, A.W. Chelation Enhanced Fluorescence Detection of Non-metal Ions, J. Am. Chem. Soc., 1989, 111, 8735.
Akkaya, E.U.; Czarnik, A.W. Synthesis and Reactivity of Cobalt(III) Complexes Bearing Primary and Secondary Side Cyclodextrin Binding Sites: A Tale of Two CD’s, J. Am. Chem. Soc., 1988, 110, 8553.