島嶼灰狐在[[聖克利門蒂島]]對瀕危的[[呆頭伯勞]]造成威脅，[[美國海軍]]在島上大量的捕殺島嶼灰狐亦使得牠們數量下降。直至2000年，美國海軍就曾使用不同的策略，包括在呆頭伯勞繁殖期間捕捉島嶼灰狐、在呆頭伯勞的生活範圍內安裝電網，及使用電震頸環等。<ref name="navy">{{Cite book | author = United Sates Navy | year = 2000 | url = http://www.cnrsw.navy.mil/Facility/news5.pdf | title = San Clemente Island Range Complex Environmental Impact Study: San Clemente Loggerhead numbers on the increase | publisher = San Clemente Island Environmental Impact Statement Office | location = San Diego | access-date = 2006-04-19 | archive-url = https://web.archive.org/web/20070206161015/http://www.cnrsw.navy.mil/facility/news5.pdf | archive-date = 2007-02-06 | dead-url = yes }}</ref>在聖克利門蒂島、[[聖尼古拉斯島]]及聖卡塔林納島上被車撞斃的島嶼灰狐亦不少。

[[美國國家公園]]在[[聖米格爾島]]、[[聖羅莎島]]及[[聖克魯茲島]]展開了養殖島嶼灰狐的計劃，成功的將島嶼灰狐的數量增加。於2004年，就有38頭聖米格爾島嶼灰狐，在聖羅莎島就有46頭受護養的及7頭野生的島嶼灰狐，聖克魯茲島上有25頭受護養的島嶼灰狐及100頭穩定的數量。<ref name="coonan2003" />而聖卡塔林納島保育委員會亦展開了養殖島嶼灰狐的計劃，於2002年，就有17頭島嶼灰狐受護養，及最少有161頭生的島嶼灰狐。<ref name="catalina2002">{{Cite book | author = Kohlmann, S. G. et al. | year = 2003 | title = Island fox recovery efforts on Santa Catalina Island, California, October 2001–October 2002, Annual Report | publisher = Ecological Restoration Department, Santa Catalina Island Conservancy | location = Avalon, California}}</ref>