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== 婚姻和晚年生活 ==

1495年3月5日，丽莎与弗朗切斯科·迪巴托洛梅奥·迪扎诺比·德尔·焦孔多（{{lang|it|Francesco di Bartolomeo di Zanobi del Giocondo}}）成婚。弗朗切斯科是个商人，在经营[[纺织品|布料]]和[[丝绸]]的生意上还算成功。丽莎嫁给他时年仅15岁，嫁妆是170[[弗罗林]]，加上娘家乡间别墅附近的圣西尔维斯特农场，这说明当时格拉迪尼家族已不算很富裕，夫妻两人应该是真心相爱。<ref name="Zöllner" />{{rp|5}}圣西尔维斯特农场位于[[卡斯泰利纳伊恩基亚恩蒂|卡斯泰利纳]]和圣多纳托之间，与之后[[米开朗基罗]]拥有的两个农场距离很近<ref name="Pallanti-2006" />{{rp|45-46}}。夫妻两人在佛罗伦萨属中产阶级，这次婚姻有可能提升了丽莎的[[社会地位]]，因为丈夫的家族可能更加富有<ref name="Zöllner" />{{rp|5}}。弗朗切斯科也从此次婚姻获益，因为格拉迪尼是老贵族名号<ref name="Kemp">{{cite book | author = Kemp, Martin | title = Leonardo Da Vinci: The Marvellous Works of Nature And Man | url = http://books.google.com.hk/books?id=1-t_dJh-_mUC&pg=PA261&hl=zh-CN | pages = 261–262 | publisher = Oxford University Press via Google Books limited preview | isbn = 0-19-280725-0 | year = 2006 | accessdate = 2014-10-01 | deadurl = no | archiveurl = https://web.archive.org/web/20141006083823/http://books.google.com.hk/books?id=1-t_dJh-_mUC&pg=PA261&hl=zh-CN | archivedate = 2014-10-06 }}</ref>。1503年3月5日，弗朗切斯科在家族旧居隔壁买下一套房子，与夫人一起搬进去，估计列奥纳多也正是在这年开始为丽莎画像<ref>{{cite web|title=Portrait of Lisa Gherardini, wife of Francesco del Giocondo |deadurl=no |archiveurl=https://web.archive.org/web/20140730003620/http://www.louvre.fr/en/oeuvre-notices/mona-lisa-%E2%80%93-portrait-lisa-gherardini-wife-francesco-del-giocondo |archivedate=2014-07-30 |url=http://www.louvre.fr/en/oeuvre-notices/mona-lisa-%E2%80%93-portrait-lisa-gherardini-wife-francesco-del-giocondo |publisher=Musée du Louvre |accessdate=2014-07-30 }}</ref><ref name="Zöllner" />{{rp|9}}。

丽莎与弗朗切斯科一共有五个孩子，分别叫皮埃罗、卡米拉、安德烈亚、焦孔多和玛丽埃塔，其中四个是在1496到1507年间出生<ref name="Johnston">{{cite news | author = Johnston, Bruce | title = Riddle of Mona Lisa is finally solved: she was the mother of five | work = Telegraph.co.uk | publisher = Telegraph Media Group | archivedate = 2014-05-17 | archiveurl = https://web.archive.org/web/20140517092946/http://www.telegraph.co.uk/news/worldnews/europe/italy/1468392/Riddle-of-Mona-Lisa-is-finally-solved-she-was-the-mother-of-five.html | date = 2004-01-01 | accessdate = 2014-10-01 | deadurl = no | url = http://www.telegraph.co.uk/news/worldnews/europe/italy/1468392/Riddle-of-Mona-Lisa-is-finally-solved-she-was-the-mother-of-five.html}}</ref>，丽莎还有个1499年夭折的小女儿<ref name="Zöllner" />{{rp|4}}。