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周金秋
,创建页面,内容为“{| class="wikitable" align="right" |- | style="background: #FF2400" align= center| '''<big>周金秋</big>''' |- |<center><img src=https://teacher.ucas.ac.cn/self/…”
{| class="wikitable" align="right"
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| style="background: #FF2400" align= center| '''<big>周金秋</big>'''
|-
|<center><img src=https://teacher.ucas.ac.cn/self/img/afd6c08a-1d01-4e98-a707-e389bec3f0d4.jpg width="300"></center>
<small>[https://teacher.ucas.ac.cn/~jinqiuzhou?language=en 来自 网络 的图片]</small>
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| style="background: #FF2400" align= center|
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| align= light|
|}
<ref>[html 周金秋 ],搜狐, 2021-06-27</ref>
周金秋,男,表观遗传学家研究员,研究组长,博士生导师。
现任中国科学院分子细胞科学卓越创新中心副主任,分子生物学国家重点实验室主任。
==基本信息==
人物说明----中国科学院分子细胞科学卓越创新中心副主任,分子生物学国家重点实验室主任
民 族 ---- 汉族
出生地点----
出生日期----
国 籍 ---- 中国
职 业 ---- 教育科研工作者
主要成就----
毕业院校----南京大学、迈阿密大学
职 称 ---- 研究员
==目录==
1人物经历 ▪教育经历 ▪工作经历 ▪社会兼职 2科研活动 ▪科研项目 ▪参与会议 3研究方向 4代表论文
==人物经历==
===教育经历===
1984-09--1988-06 就读于南京大学生物系,获学士学位
1992-08--1997-05 就读于美国迈阿密大学医学院生物化学与分子生物学系,获博士学位
===工作经历===
1988-07~1992-07,中科院上海生化所, 研究助理
1997-06~1998-05,美国迈阿密大学医学院, 博士后
1998-07~2001-09,美国普林斯顿大学, 博士后
2001-09~现在, 中科院上海生化细胞所, 研究员
===社会兼职===
2014-08-01-今,中国生物化学与分子生物学会, 常务理事
2014-01-01-2016-12-31,Journal of Genetics and Genomics, 编委
2013-01-01-今,上海科技大学, 兼职教授
2012-07-01-2017-06-30,Journal of Biological Chemistry, 编委
2011-07-01-2016-06-30,PLoS Genetics, 副主编(Associate Editor)
2009-06-01-今,Journal of Molecular and Cellular Biology, 副主编
2007-01-01-2010-12-31,“Mechanisms of Aging and Development”杂志的编辑顾问委员会委员,
2003-01-01-今,中国生物化学与分子生物学会理事,
2003-01-01-今,中国遗传学会理事,
2003-01-01-今,中国细胞生物学会理事,
2002-02-01-2007-01-30,中国科学院与德国马普学会合作的青年科学家小组组长
==科研活动==
===科研项目===
( 1 ) 干细胞编程与重编程中表观遗传密码建立和维持的分子机制和结构基础, 参与, 国家级, 2011-01--2015-08
( 2 ) 组蛋白H4的K5/8/12乙酰化“密码”的建立和解读, 主持, 国家级, 2009-01--2012-12
( 3 ) 干细胞编程与重编程中表观遗传密码建立和维持的分子机制和结构基础, 参与, 国家级, 2011-01--2015-12
( 4 ) 端粒与染色体稳定性, 主持, 国家级, 2013-01--2017-08
( 5 ) 染色质共价修饰在表观遗传调控中的机制研究(表观遗传学), 主持, 国家级, 2013-01--2015-12
( 6 ) 端粒异染色质形成的分子基础, 主持, 国家级, 2013-01--2017-12
( 7 ) 端粒长度的遗传调控机制, 主持, 国家级, 2014-10--2016-09
( 8 ) 染色质共价修饰在表观遗传调控中的机制研究(表观遗传学), 主持, 国家级, 2016-01--2018-12
( 9 ) 表观遗传调控中关键蛋白质机器的结构功能研究, 参与, 国家级, 2016-07--2020-12
( 10 ) 单染色体酵母细胞染色体遗传机制研究, 主持, 省级, 2018-12--2021-11
( 11 ) 染色体改造单倍体干细胞的构建及应用, 主持, 国家级, 2019-10--2023-12
( 12 ) 创建单条染色体小鼠研究, 主持, 部委级, 2019-09--2023-12
===参与会议===
(1)Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription 第三届遗传学和基因组学前沿会议 2017-10-09
(2)KEOPS Complex Affects DNA Double-Strand Break Repair by Promotion DNA End Resection 第十届中国模式真菌研讨会 2017-06-09
(3)Modifications on both sister histone H3s coordinate to regulate chromatin structure and transcription 第十二次全国基因功能与表观遗传调控学术研讨会 2017-06-01
(4)Asymmetrically modified nucleosomes poise genes for activation or repression 2016年度全国生化大会 2016-10-20
(5)Inhibition of telomere recombination promotes yeast cell longevity 2016-09-09
(6)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 苏州冷泉港 2016-09-05
(7)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 苏州冷泉港 2016-09-05
(8)Asymmetrically modified nucleosomes poise genes for activation/repression in yeast 第七届全国微生物遗传学学术研讨会 2016-08-05
(9)第九届中国模式真菌研讨会 2016-06-17
(10)The KEOPS complex regulates telomere replication and recombination independently of tRNA modification 苏州冷泉港 2016-06-13
(11)Asymmetrically modified nucleosomes poise gene activation/repression in yeast 苏州冷泉港 2016-05-09
(12)Inhibition of Telomere Recombination Promotes Cell Longevity 第十五届美洲华人生物科学学会学术研讨会 2015-06-26
(13)第八届中国模式真菌研讨会 2015-06-12
(14)Hmt1 dimer fulfills methylation of histone H3 arginine 2 in trans 第七届中国模式真菌研讨会 李宏韬 2014-05-30
(15)Histone H4 lysine 12 acetylation regulates telomere dynamics in Saccharomyces cerevisiae 染色质与表观遗传研讨会 Bo Zhou 2010-05-16
(16)The function of Est1p and Est3p in regulation of telomerase activity in Saccharomyces cerevisiae 第66届日本癌症学会年会 Jinqiu Zhou 2007-10-05
==研究方向==
染色质与细胞衰老
实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。
==代表论文==
(1) A single circular chromosome yeast, Cell Research, 2019, 通讯作者
(2) Yeast KEOPS complex regulates telomere length independently of its t6A modification function, Nucleic Acids Research, 2019, 通讯作者
(3) Creating a functional single-chromosome yeast, Nature, 2018, 通讯作者
(4) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae, DNA Repair, 2018, 通讯作者
(5) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae, Journal of Genetics and Genomics, 2018, 通讯作者
(6) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection, Nucleic Acids Research, 2017, 通讯作者
(7) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300, Cell Discovery, 2017, 第 10 作者
(8) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, elife, 2017, 通讯作者
(9) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast, Journal of Genetics and Genomics, 2016, 通讯作者
(10) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast, Aging, 2016, 通讯作者
(11) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity, PloS Genetics, 2015, 通讯作者
(12) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Biochemical Journal, 2015, 通讯作者
(13) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors, PloS One, 2014, 通讯作者
(14) Telomerase-null survivor screening identifies novel telomere recombination regulators, Plos Genetics, 2013, 通讯作者
(15) Characterization of the intramolecular G-quadruplex promoting activity of Est1, FEBS Letters, 2013, 通讯作者
(16) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance, Nucleic Acids Resserch, 2012, 通讯作者
(17) Recent transcription-induced histone H3K4 methylation inhibits gene reactivation, J. Biol. Chem., 2011, 通讯作者
(18) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 Promoter, Molecular Cell Biology, 2011, 通讯作者
(19) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae, Plos Genetics, 2011, 通讯作者
(20) Est1 Protects Telomeres and Inhibits Subtelomeric Y�-Element Recombination, Molecular Cell Biology, 2011, 通讯作者
(21) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation, Nature Structural and Molecular Biology, 2010, 通讯作者
(22) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation, Molecular Cell Biology, 2010, 通讯作者
(23) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin, Proceedings of the National Academy of Sciences, 2009, 通讯作者
(24) Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae, Plos Genetics, 2009, 通讯作者
(25) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation, Nucleic Acids Research, 2009, 通讯作者
(26) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication, The EMBO Journal, 2009, 通讯作者
(27) Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation, Cell Research, 2009, 通讯作者
(28) Candida albicans,a distinctive fungal model for cellular aging study, Aging Cell, 2008, 通讯作者
(29) Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3, Nucleic Acids Research, 2006, 通讯作者
(30) Characterization of ATPase Activity of Recombinant Human Pif1, Acta Biochimica et Biophysica Sinica, 2006, 通讯作者
(31) Schizosaccharomyces pombe pfh1� Encodes an Essential 5� to 3� DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases, Molecular Biology of the Cell, 2002, 第 1 作者
(32) Saccharomyces Rrm3p, a 5� to 3� DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA, Genes and Development, 2002, 第 1 作者
(33) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast, Science, 2000, 第 1 作者
(34) The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA, Cell, 2000, 第 1 作者
==参考来源==
[[Category:教授]] [[Category:生物学家]]
|-
| style="background: #FF2400" align= center| '''<big>周金秋</big>'''
|-
|<center><img src=https://teacher.ucas.ac.cn/self/img/afd6c08a-1d01-4e98-a707-e389bec3f0d4.jpg width="300"></center>
<small>[https://teacher.ucas.ac.cn/~jinqiuzhou?language=en 来自 网络 的图片]</small>
|-
| style="background: #FF2400" align= center|
|-
| align= light|
|}
<ref>[html 周金秋 ],搜狐, 2021-06-27</ref>
周金秋,男,表观遗传学家研究员,研究组长,博士生导师。
现任中国科学院分子细胞科学卓越创新中心副主任,分子生物学国家重点实验室主任。
==基本信息==
人物说明----中国科学院分子细胞科学卓越创新中心副主任,分子生物学国家重点实验室主任
民 族 ---- 汉族
出生地点----
出生日期----
国 籍 ---- 中国
职 业 ---- 教育科研工作者
主要成就----
毕业院校----南京大学、迈阿密大学
职 称 ---- 研究员
==目录==
1人物经历 ▪教育经历 ▪工作经历 ▪社会兼职 2科研活动 ▪科研项目 ▪参与会议 3研究方向 4代表论文
==人物经历==
===教育经历===
1984-09--1988-06 就读于南京大学生物系,获学士学位
1992-08--1997-05 就读于美国迈阿密大学医学院生物化学与分子生物学系,获博士学位
===工作经历===
1988-07~1992-07,中科院上海生化所, 研究助理
1997-06~1998-05,美国迈阿密大学医学院, 博士后
1998-07~2001-09,美国普林斯顿大学, 博士后
2001-09~现在, 中科院上海生化细胞所, 研究员
===社会兼职===
2014-08-01-今,中国生物化学与分子生物学会, 常务理事
2014-01-01-2016-12-31,Journal of Genetics and Genomics, 编委
2013-01-01-今,上海科技大学, 兼职教授
2012-07-01-2017-06-30,Journal of Biological Chemistry, 编委
2011-07-01-2016-06-30,PLoS Genetics, 副主编(Associate Editor)
2009-06-01-今,Journal of Molecular and Cellular Biology, 副主编
2007-01-01-2010-12-31,“Mechanisms of Aging and Development”杂志的编辑顾问委员会委员,
2003-01-01-今,中国生物化学与分子生物学会理事,
2003-01-01-今,中国遗传学会理事,
2003-01-01-今,中国细胞生物学会理事,
2002-02-01-2007-01-30,中国科学院与德国马普学会合作的青年科学家小组组长
==科研活动==
===科研项目===
( 1 ) 干细胞编程与重编程中表观遗传密码建立和维持的分子机制和结构基础, 参与, 国家级, 2011-01--2015-08
( 2 ) 组蛋白H4的K5/8/12乙酰化“密码”的建立和解读, 主持, 国家级, 2009-01--2012-12
( 3 ) 干细胞编程与重编程中表观遗传密码建立和维持的分子机制和结构基础, 参与, 国家级, 2011-01--2015-12
( 4 ) 端粒与染色体稳定性, 主持, 国家级, 2013-01--2017-08
( 5 ) 染色质共价修饰在表观遗传调控中的机制研究(表观遗传学), 主持, 国家级, 2013-01--2015-12
( 6 ) 端粒异染色质形成的分子基础, 主持, 国家级, 2013-01--2017-12
( 7 ) 端粒长度的遗传调控机制, 主持, 国家级, 2014-10--2016-09
( 8 ) 染色质共价修饰在表观遗传调控中的机制研究(表观遗传学), 主持, 国家级, 2016-01--2018-12
( 9 ) 表观遗传调控中关键蛋白质机器的结构功能研究, 参与, 国家级, 2016-07--2020-12
( 10 ) 单染色体酵母细胞染色体遗传机制研究, 主持, 省级, 2018-12--2021-11
( 11 ) 染色体改造单倍体干细胞的构建及应用, 主持, 国家级, 2019-10--2023-12
( 12 ) 创建单条染色体小鼠研究, 主持, 部委级, 2019-09--2023-12
===参与会议===
(1)Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription 第三届遗传学和基因组学前沿会议 2017-10-09
(2)KEOPS Complex Affects DNA Double-Strand Break Repair by Promotion DNA End Resection 第十届中国模式真菌研讨会 2017-06-09
(3)Modifications on both sister histone H3s coordinate to regulate chromatin structure and transcription 第十二次全国基因功能与表观遗传调控学术研讨会 2017-06-01
(4)Asymmetrically modified nucleosomes poise genes for activation or repression 2016年度全国生化大会 2016-10-20
(5)Inhibition of telomere recombination promotes yeast cell longevity 2016-09-09
(6)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 苏州冷泉港 2016-09-05
(7)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 苏州冷泉港 2016-09-05
(8)Asymmetrically modified nucleosomes poise genes for activation/repression in yeast 第七届全国微生物遗传学学术研讨会 2016-08-05
(9)第九届中国模式真菌研讨会 2016-06-17
(10)The KEOPS complex regulates telomere replication and recombination independently of tRNA modification 苏州冷泉港 2016-06-13
(11)Asymmetrically modified nucleosomes poise gene activation/repression in yeast 苏州冷泉港 2016-05-09
(12)Inhibition of Telomere Recombination Promotes Cell Longevity 第十五届美洲华人生物科学学会学术研讨会 2015-06-26
(13)第八届中国模式真菌研讨会 2015-06-12
(14)Hmt1 dimer fulfills methylation of histone H3 arginine 2 in trans 第七届中国模式真菌研讨会 李宏韬 2014-05-30
(15)Histone H4 lysine 12 acetylation regulates telomere dynamics in Saccharomyces cerevisiae 染色质与表观遗传研讨会 Bo Zhou 2010-05-16
(16)The function of Est1p and Est3p in regulation of telomerase activity in Saccharomyces cerevisiae 第66届日本癌症学会年会 Jinqiu Zhou 2007-10-05
==研究方向==
染色质与细胞衰老
实验室的长远目标是探索真核细胞维持染色体稳定性的机制和细胞衰老的机理。
==代表论文==
(1) A single circular chromosome yeast, Cell Research, 2019, 通讯作者
(2) Yeast KEOPS complex regulates telomere length independently of its t6A modification function, Nucleic Acids Research, 2019, 通讯作者
(3) Creating a functional single-chromosome yeast, Nature, 2018, 通讯作者
(4) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae, DNA Repair, 2018, 通讯作者
(5) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae, Journal of Genetics and Genomics, 2018, 通讯作者
(6) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection, Nucleic Acids Research, 2017, 通讯作者
(7) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300, Cell Discovery, 2017, 第 10 作者
(8) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, elife, 2017, 通讯作者
(9) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast, Journal of Genetics and Genomics, 2016, 通讯作者
(10) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast, Aging, 2016, 通讯作者
(11) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity, PloS Genetics, 2015, 通讯作者
(12) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Biochemical Journal, 2015, 通讯作者
(13) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors, PloS One, 2014, 通讯作者
(14) Telomerase-null survivor screening identifies novel telomere recombination regulators, Plos Genetics, 2013, 通讯作者
(15) Characterization of the intramolecular G-quadruplex promoting activity of Est1, FEBS Letters, 2013, 通讯作者
(16) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance, Nucleic Acids Resserch, 2012, 通讯作者
(17) Recent transcription-induced histone H3K4 methylation inhibits gene reactivation, J. Biol. Chem., 2011, 通讯作者
(18) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 Promoter, Molecular Cell Biology, 2011, 通讯作者
(19) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae, Plos Genetics, 2011, 通讯作者
(20) Est1 Protects Telomeres and Inhibits Subtelomeric Y�-Element Recombination, Molecular Cell Biology, 2011, 通讯作者
(21) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation, Nature Structural and Molecular Biology, 2010, 通讯作者
(22) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation, Molecular Cell Biology, 2010, 通讯作者
(23) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin, Proceedings of the National Academy of Sciences, 2009, 通讯作者
(24) Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae, Plos Genetics, 2009, 通讯作者
(25) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation, Nucleic Acids Research, 2009, 通讯作者
(26) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication, The EMBO Journal, 2009, 通讯作者
(27) Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation, Cell Research, 2009, 通讯作者
(28) Candida albicans,a distinctive fungal model for cellular aging study, Aging Cell, 2008, 通讯作者
(29) Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3, Nucleic Acids Research, 2006, 通讯作者
(30) Characterization of ATPase Activity of Recombinant Human Pif1, Acta Biochimica et Biophysica Sinica, 2006, 通讯作者
(31) Schizosaccharomyces pombe pfh1� Encodes an Essential 5� to 3� DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases, Molecular Biology of the Cell, 2002, 第 1 作者
(32) Saccharomyces Rrm3p, a 5� to 3� DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA, Genes and Development, 2002, 第 1 作者
(33) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast, Science, 2000, 第 1 作者
(34) The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA, Cell, 2000, 第 1 作者
==参考来源==
[[Category:教授]] [[Category:生物学家]]