厚皮甜瓜是单性(monoecious)植物。它们不与[[西瓜]]，[[黄瓜]]，[[南瓜]]或西葫芦杂交，但是物种内的品种经常杂交<ref>{{cite web|url=http://aggie-horticulture.tamu.edu/archives/parsons/publications/vegetabletravelers/muskmelon.html|title=Muskmelons Originated in Persia - Archives - Aggie Horticulture|author=Martin Anderson, Texas AgriLife Extension Service|work=tamu.edu}}</ref> 。 [[黄瓜]]（Cucumis melo L.）的基因组在2012年首先测序<ref>{{cite journal|url=http://www.pnas.org/content/early/2012/06/28/1205415109.short|title=The genome of melon (Cucumis melo L.)|author=Jordi Garcia-Mas | doi=10.1073/pnas.1205415109|volume=109|journal=Proceedings of the National Academy of Sciences|pages=11872–11877}}</ref> 。