彭以元檢視原始碼討論檢視歷史

彭以元

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彭以元，男，博士，1964年2月生。 致公黨，江西師範大學化學學院、生命科學學院二級教授，化學生物學博士生導師;有機化學、應用化學、生物科學、生態學、生物化工碩士生導師。擔任江西師範大學化學化工學院院長、功能有機小分子教育部重點實驗室主任、 江西省綠色化學重點實驗室主任。入選江西省新世紀百千萬人才工程，江西省高等學校中青年學科帶頭人、江西省省人民政府學科評議組成員，贛鄱"555"領軍人才。

基本信息

人物說明----江西師範大學化學化工學院院長

出生日期----1964年2月

出生地點----江西吉水

國 籍 ---- 中國

職 業 ---- 教育科研管理工作者

畢業院校----江西師範大學

主要經歷

1981.9~1985.7 在江西師範大學化學系學習，1985年大學本科畢業。

1985.9~1988.12 在上海有機化學研究所攻讀碩士研究生，師從蔣錫夔院士和趙成學教授，畢業論文題目為:伯胺氧化生成含氟氮氧自由基的方法、反應機理。

1988.12~1990.4 在上海有機所從事研究工作。

1990.5~1994.6 在江西省化工研究所從事有機硅產品開發、應用研究。

1995.7~2000.9 在江西師範大學化學系，從事有機硅化學、含氟氮氧自由基化學和量子化學計算的基礎研究和教學工作。

2000.9~2003.6 在南開大學化學學院化學系讀在職博士。

2003.7~2009.2 在江西師範大學化學化工學院工作，從事有機硅化學、綠色化學、化學生物學研究。

2009.3~ 在江西師範大學生命科學學院從事教學科研工作。

職稱情況

1992年被聘為工程師。

1996年被破格評聘為副教授，有機化學碩士研究生導師。

2001年被破格評聘為教授。

科研成果

獲得三個國家自然科學基金和一個國際合作項目資助。共完成省部級以上項目十餘項，如下:

Ⅰ.已完成的省科委下達的技術重點項目

1. 2004 年負責完成江西省重點攻關項目:織物整理劑--有機氟硅乳液的研製

2. 1998-2000年負責完成江西省重點攻關項目: KBM802及巰基改性硅油的研製

3. 1996 –1997年負責完成江西省重點項目: 硅偶聯劑KBM602、KBM603的合成

遊戲

來自 網絡 的圖片

4. 1995~1996年負責完成省計委扶貧項目:黃麻纖維板材及其製品的研製

5. 1993~1994年負責完成江西省一級重點項目:氨基改性硅油的研製

6. 1992~1993年參與並完成兩項新藥物中間體的研製:脒基硫脲和1,3-二氯丙酮的小試研製和工業化中試生產

7. 1990~1991年參與完成江西省重點攻關項目:高溫硫化硅橡膠的研製，該項目獲江西省科技進步二等獎。

Ⅱ.已完成的基礎研究項目

1. 2008年完NIH(國家衛生局)開放基金項目:腦蛋白凝聚機理、診斷及其成像劑研究

2. 2007年完成國家自然科學基金項目: 綠色溶劑中氨基酸及多肽催化不對稱直接催化aldol類反應

3. 2004年完成國家自然科學基金項目:水相及膠束中氨基酸及多肽直接催化aldol類反應

4. 2004年南開大學元素有機國家重點實驗室開放基金項目:水相中氨基酸催化aldol 反應研究

5. 2001~2003負責江西省自然科學基金項目:有機硅樹脂支持的合成反應

6. 1997~1998年負責完成江西省青年基金項目:新型氮氧自由基的結構與性能研究。

Ⅲ.正在負責的在研項目

1.負責江西省重點工業攻關項目:有機硅氟攻性材料的研製

2.國家自然科學基金項目:神經退化疾病中的α-synuclein澱粉蛋白質小分子探針的研究

3.省自然科學基金項目:α-synuclein澱粉蛋白質小分子探針合成

4.9省教委教改課題: 礎化學實驗一體化課程改革及教材建設研究項目資助通知;

教學情況

Ⅰ.開設研究生課

1. 研究生課: 《有機結構分析--波譜解析》

2. 研究生課: 《量子有機化學》

3. 研究生基礎課 《有機化學合成》

4. 研究生基礎課 《不對稱合成》

5. 研究生專業課 《化學生物學》

Ⅱ.開設的本科教學課程

1. 本科生基礎課《有機化學》

2. 本科生基礎課《有機化學實驗》

3. 本科基礎課:《結構化學》

4. 本科必選課: 《有機合成》

5. 本科選修課: 《現代分子結構測定的原理與方法》

6. 本科選修課: 《綠色化學概論》

Ⅲ. 共培養了22名碩士研究生。

所獲榮譽

1. 2000年獲上海市科技進步三等獎。

2. 江西省政協委員

3. 國際期刊Tetrahedron: Asymmetry 通信評委

最近發表論

1. Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters, Eur. J. Org. Chem. 2014, 511-514.

2. Cross-coupling/annulations of quinazolones with alkynes for access to fused polycyclic heteroarenes under mild conditions, Org. Biomol. Chem., 2014，12，758-764.

3. Palladium-Catalyzed Cyanation of Quinazoline-4-tosylates forAccess to 4-CN Functionalized Quinazolines, Synthesis 2013, 45, 3245-3250.

4. Syntheis of 4-arylquinazolines by Arylation of 4- Arylquinazolinones under mild conditions Synthesis 2013, 45, 3131-3136.

5. Synthesis of 4-Sulfanylcoumarins Using Thiourea and Alkyl Halides as the Sulfanylation Agent in Polyethylene Glycol-Water Synthesis 2013, 45, 759-766.

6. Palladium-catalyzed direct ortho-acylation through an oxidative coupling of 2-arylbenzothiazoles with benzylic alcohols Tetrahedron 2013，69，8661-8667.

7. Palladium-catalyzed C-H bond functionalization/oxidative acyloxylation of 2-aryl-benzo[d]thiazoles, J. Organometallic Chem2013, 739, 33-39

8. New simple synthesis of ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thiones: Direct formation from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles Beilstein J. Org. Chem. 2013, 9, 460-466.

9. Dual effects of (t)-catechin on hemin-induced oxidative reactions: A potential pharmacological implication Free Radicals and Antioxidants, 2013 3 11-16.

10. Effects of quercetin on hemoglobin-dependent redox reactions relationship to iron-overload rat liver injury, J. Asian Natural Products Research, 2013,15,1265-1276.

11. Construction of heterocyclic scaffolds via transition metal-catalyzed sp3 C-H functionalization J. Organometallic Chem2013, 723, 224-232

12. Metal Co-Catalyzed Tandem Alkynylative Cyclization Reaction of in situ formed N-Iminoisoquinolinium Ylides with Bromoalkynes via C-H Bond Activation, J. Organic Chem.2012, 77,8092-8098.

13. N-Heterocyclic Carbene Catalyzed One-Pot Synthesis of 2,3-Diarylquinoxalines Sythesis 2012, 44, 2699-2706

14. Silver Triflate and Palladium Acetate Co-catalyzed Reaction of N-(2-Alkynylbenzylidene)hydrazide with N-Allyl Ynamid Org Lett. 2012, 14, 2790-2793.

15. Novel Silver Tetrafluoroborate Catalyzed Electrophilic Cascade Cyclization Reaction: A Facile Approach to the Synthesis of Halo-Substituted Benzo[a]fluorenols, Org Lett. 2012, 14, 3588-3590.

16. Direct Sulfanylation of 4-Quinazolinone via C–OH Bond Activation: An Efficient Route to 2-Aryl-4-sulfanylquinazolines Sythesis 2012, 44, 1237-1246.

17. Enhancement of nitrite on heme-induced oxidative reactions: A potential toxicological implication, Toxicology in Vitro 2012,26, 81-85.

18. Synthesis of 1,3-Dihydrobenzo[c]thiophene-imines via Tandem Reactions of o-(1-Alkynyl)benzamides and Lawesson's Reagent, Sythesis 2012, 44, 920-926.

19. One-pot two-step synthesis of 1-position arylated 1,3-disubstituted isoquinoline N-oxides Tetrahedron 2012，68 ,8869-8874.

20. Access to functionalized 4-benzylidene-4H-benzo[d][1,3]thiazines via tandem addition-cyclization/cross-coupling reactions Tetrahedron 2012，68，3937-3941.

21. Pd(II)-catalyzed ortho arylation of 2-arylbenzothiazoles with aryl iodide via benzothiazole-directed C-H activation.Journal of Organometallic Chemistry 2012，711, 62-67.

22. Facile assembly of cyclopenta[c]quinolin-3-ols via a palladium-catalyzed reaction of 2-alkynylaniline with 2-alkynylvinyl bromide Tetrahedron 2012，68，9004-9008.

23. Synthesis of 4-methylene-4H-benzo[d][1,3]thiazines via a tandem reaction of 1-(2-alkynylphenyl)ketoximes with Lawesson's reagent, Chem. Commun. 2011 9708–9710.

24. Rapid access to 4-substituted-pyrones and 2(5H)-furanones via a palladiumcatalyzed CeOH bond activation Tetrahedron 2011，67， 7258-7262

25. An efficient approach to pyrazolo[5,1-a]isoquinolin-2-amines via a silver(I)-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and nitrile Org. Biomol. Chem., 2011 7033-7037

26. Generation of diverse 2-pyrones via palladium-catalyzed site-selective Suzuki-Miyaura couplings of 3-bromo-4-tosyloxy-2-pyrone Org. Biomol. Chem., 2011，9，6265-6270

27. Efficient Assembly of 1-(1H-Imidazol-1-yl)-3-methylene-1H-indenes via Tandem Reaction of (2-(Alkynyl)benzylidene)malonates with Imidazoles Combinatorial Science, 2011, 13, 13-18

28. Generation of 3-(1H-Isochromen-1-yl)-1H-indole via Silver Triflate-Catalyzed Tandem Reaction of 2-Alkynylbenzaldehyde with Indole, Heterocycles 2011, 82, 1239-1249.

29. Cationic Micelle-catalyzed Ring-Opening Reactions of Aziridines with Thiols in Water Chinese Journal of Chemistry 2011, 29,499-503·

30. Aqueous C-S cross-coupling:synthesis of 2-iminobenzo-1,3-oxathioles via CuCl2·H2O -catalyzed tandem reaction of 2-iodophenols with isothiocyanates Tetrhedron lett. 2011, 52, 1964-1967.

31. Synthesis of thioethers via metal-free reductive coupling of tosylhydrazones with thiols· Org. Biomol. Chem., 2011, 9, 748–751.

32. Iron-catalyzed tandem reactions of ortho-aminobenzenethiols with isothiocyanates leading to 2-aminobenzoazoles under ligandand solvent-free conditions, Phosphorus, Sulfur, and Silicon, 2011, 186, 1782–1789.

33. Effects of glutathione, Trolox and desferrioxamine on hemoglobin-induced protein oxidative damage: anti-oxidant or pro-oxidant· European Journal of Pharmacology，2011，659，95-101

34. Anti- and pro-oxidant effects of (+)-catechin on hemoglobin-induced protein oxidative damage·Toxicology in Vitro, 2011, 52,833-838·

35. Pyridine-N-oxide: An Efficient Organocatalyst for Ring-Opening Reactions of Aziridines with Thiols，Chinese Journal of Chemistry 2011, 29,79-84

36. Pyridinium tribromide catalyzed condensation of indoles and aldehydes to form bisindolylalkanes Chinese Chemical letters, 2011, 22,515-518

37. Multicatalytic One-Pot Reaction of 1-(2-Alkynylphenyl)ketoximes for Generation of Indole Derivatives， Orglett. 2010, 12, 3975-3977.

38. Synthesis of 2-aminobenzothiazole via FeCl3-catalyzed tandem reaction of 2-iodoaniline with isothiocyanate in water·Green chemistry 2010, 12,1607-1610·

39. Room-Temperature Highly Efficient Suzuki-Miyaura Reactions in Water in the Presence of Stilbazo，Green chemistry 2010,12, 1072-1075.

40. Silica Gel-Promoted Tandem Addition Cyclization Reactions of 2-Alkynylbenzenamines with Isothiocyanates· J. Comb. Chem. 2010, 12, 370–373.

41. Iron-Catalyzed one-pot synthesis of 2-aminobenzothiazoles from 2-aminobenze -thiols and isothiocynates under ligand-free conditions in water. Heterocycles 2010,81, 2841-2847.

42. A convenient one-pot procedure for the synthesis of 2-aryl quinazolines using active MnO2 as oxidant，J. Heterocycl. Chem. 2010, 47，1240-1245.

43. Synthesis of (Z)-1-benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarbonitriles via three-component reaction of of 2-alkynylbenzaldehyde, malononitrile, and indole Tetrhedron lett. 2010, 51, 4391-4394.

44. 無溶劑條件下脯氨酸甲酯催化syn選擇性羥醛縮合反應 有機化學, 2010, 30, 389-394.

45. An efficient route to 4-substituted coumarins, 2(5H)-furanones, and pyrones via palladium-catalyzed couplings of alkenyl tosylates with organoindium reagents Tetrhedron lett. 2010, 51, 136-138.

46. Direct Sulfanylation of 4-Hydroxycoumarins with Thiols in Water Tetrahedron Lett. 2009, 50, 2405-2406.

47. Highly efficient electrophilic cyclization of N-(2-alkynylbenzylidene)hydrazides, Tetrahedron Lett. 2009, 50, 340-342.

48. Highly efficient N-monomethylation of primary aryl amines Chinese Journal of Chemistry 2009, 27,1339-1344.

49. A Facile Aqueous Synthesis of Bis(indol-3-yl)alkanes Catalyzed by Dodecylbenzenesulfonic acid Chinese Journal of Chemistry 2008, 26, 2228-2232.

50. Arginine Catalyzed Direct Aldol Reactions in Pure Water:An Environmentally Friendly Reaction System Chinese Journal of Chemistry 2008, 26,1454-1460.

51. Asymmetric Synthesis of Bicyclic Piperidines via L-Proline Catalyzed Aldol Reaction of 3-Phthalimidopropanal Chrality，2008，20，805-801.

52. Pyrrolidine as an efficient organocatalyst for direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones Tetrahedron 2007, 63, 4636–4641.

53. L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction: an Environment-friendly Method for the Synthesis ofβ-Hydroxylketones Chinese Journal of Chemistry, 2007，25，962-957.

54. An Environmentally Benign System for Synthesis of β-Hydroxylketones: L-Histidine Asymmetrically Catalyzed Direct Aldol Reactions in Aqueous Micelle and Water-like Media, Chinese Journal of Chemistry, 2007, 25, 356-363.

55. Cai ,L. S.; Cuevas, J.; Peng, Y. Y.; Pike V. W. Rapid palladium-catalyzed cross-coupling in the synthesis of aryl thioethers under microwave conditions. Tetrahedron Letters 2006, 47, 4449–4452.

56. 丁酮與硝基苯甲醛反應生成的 aldol 產物的NMR 表徵方法及其應用 江西師範大學學報(自然科學版) 2006, 30， 141-144。

57. Proline Catalyzed Aldol Reactions in Aqueous Micelles: An Environmentally Friendly Reaction System Tetrahedron letter 2003 3871-3875.

58. The trifluoromethylation of 1,1-dibromo-1-alkenes using trifluoromethyl--copper (CF3Cu) generated in situ from methyl fluorosulfonyldifluoroacetate Journal of Fluorine Chemistry 2001, 111, 185-1873.

59. The sterospecific trifluoromethylation of α-iodo-α,β-unsaturated esters: a novel synthesis of (Z)-α-trifluoromethyl-α,β-unsaturated esters Journal of Fluorine chemistry 2001,108, 79~82

60. . ESR studies on the solvation of perfluoro-n-alkyl t-butry nitroxides--A new Scale for electronegativity of perfluoro-n-alkyl groups Research on Chemical Intermediates 2000, 26, 587~597.

61. AM1研究苯及取代苯甲酸亞硝酰酯熱分解反應 江西師範大學學報(自然科學版) 1998,3, 235

62. 硅烷偶聯劑KBM602的合成工藝研究 江西師範大學學報 1998, 2,153

63. 亞硝酸過氧酯熱分解反應的量子化學研究 江西師範大學學報(自然科學版) 1998,1, 61

64. Quantum chemical study on the thermal Diels-Alder reaction of cyclohexadiene and methyl crotonate Chinese Journal of Chemistry 1997, 1,21~24

65. 苯基及取代苯基四唑異構反應的量子化學研究 物理化學學報 1997, 12, 1115~1118.

66. AM1法研究取代乙烯與環己-1,3-二烯熱加成 物理化學學報 1997, 6, 532~536.

67. O-酰基羥胺衍生物的熱分解反應的理論研究 江西師範大學學報(自然科學版) 1997, 4, 354

68. 羧酸亞硝酰酯熱分解反應的量子化學研究 江西師範大學學報(自然科學版) 1997, 1, 68.

69. 甲基(γ-氯丙基)二氯硅烷的製備工藝研究 江西師範大學學報(自然科學版) 1996,4,294~298.

70. n-alkyl perfluoroacyl nitroxides─Epr studies on electron transfer reaction of perfluorodiacyl peroxides with O-benzoyl-N-alkylhydroxylamines Journal of fluorine chemistry 1993,61, 45-49.

71. Electron paramagnetic resonance studies on the generation and solvation of n- heptfluoropropyl t-butyl nitroxide Journal of fluorine chemistry, 1993, 61, 171-177.

72. 三氟甲基叔丁基氮氧自由基的超精細偶合常數與溶劑極性參數的相關研究 高等學校化學學報 1992,13(11),1448~1451. (SCI)

73. 烷基-全氟烷基酰基氮氧自由基──全氟酰基過氧化物與脂肪族伯、仲胺單電子轉移反應的EPR研究 高等學校化學學報 1992,13(2), 209-213. (SCI)

74. new method for generation of t-butyl perfluoroalkyl nitroxides Chinese Chemical Letter, 1992, 3, 611~612.

75. EPR Studies on Electron Transfer between O-benzoyl-N-alkylhydroxyl Aimines and Perfluorocyl Peroxides Research on Chemical Intermediates, 1992, 18, 1-17.