蕭偉首都師範大學生物系教授檢視原始碼討論檢視歷史
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蕭偉，博士，首都師範大學生物系教授。
概述
蕭偉，博士，首都師範大學生物系教授。
1. 學士/1982 南京農業大學
2. 碩士/1984 多倫多大學(University of Toronto)
3. 博士/1988薩斯喀徹溫大學(University of Saskatchewan)
4. 博士後 /1990-1992 哈佛大學(Harvard University)
| 蕭偉 | |
|---|---|
| 國籍 | 中國 |
| 職業 | 生物系教授 |
獲獎
薩斯喀徹溫大學年度最佳研究獎(2008)
薩斯喀徹溫大學醫學院研究生會(CMGSS)年度最佳導師獎(2007)
人物傳記被收錄於《千禧年的加拿大》(CANADA at the Millennium)(2000)
人物傳記被收錄於《加拿大名人錄》(Canadian Who's Who)(自1996)
研究領域
泛素(Ubiquitin，Ub)是一種高度保守的小蛋白(76個氨基酸)，普遍存在於從單細胞酵母到人類的所有真核細胞內，並且表達水平很高。通過一系列的酶促反應，泛素在泛素結合酶(E2或Ubc)和泛素連接酶(E3)的幫助下連接到目的蛋白。接着在一個被稱為多聚泛素鏈的泛素多聚體形成後，結合有多聚泛素鏈的目的蛋白被26S蛋白酶體降解，而這個過程是許多細胞活動調節的重要手段，2004年的諾貝爾獎授予了"泛素化的發現和它在蛋白降解中的作用"就說明了它的重要性。深入研究揭示，上述泛素鏈是由下一個泛素表面的Lys48殘基結合在上一個泛素的C末端甘氨酸殘基而形成的，隨後又發現泛素鏈也可經由表面Lys63殘基形成。在所有生物中發現的泛素結合酶中，只有Ubc13能夠專一通過Lys63連接泛素。Ubc13的獨特性質是基於它和另一個被稱作泛素結合酶異構體的蛋白的結合，而這種異構體也是Lys63多聚泛素化過程所必須的。更重要的是，被Lys63連接的泛素所結合的目的蛋白不是為了降解，而是為了改變其活性。此外，在其他泛素化類型中，單一泛素化也被認為是一種新穎的蛋白質活性調節機制，拓寬了人們對泛素化功能的認識。本實驗室的主要興趣在於發現上述非常規泛素化過程和探索相關途徑的分子機制。因為一些研究的很透徹的非常規泛素化目的蛋白參與一些重要的細胞代謝過程，如DNA損傷耐受、細胞周期檢驗點、自然免疫和應激反應，而且這些過程在人類疾病中起關鍵作用，如癌症，抗病及衰老，所以這項研究將會對包括癌症在內的多種疾病診斷和治療產生直接影響。
發表論文
Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Tox. Sci. 113: 401-411.
Ball, L.G., Zhang, K., Cobb, J.A., Boone, C. and Xiao, W. (2009) The yeast Shu complex couples error-free PRR to homologous recombination. Mol. Microbiol. 73: 89-102. [Text]
Ball, L. and Xiao, W. (2009) Ataxia telangiectasia and its overlap with Nijmegen breakage syndrome and Ataxia-like disorders. In: Ahmad, S. (ed.) Molecular Mechanisms of Ataxia Telangiectasia. Chapter 10, pp.91-100. Landes Biosciences Publication, Texas. [Text]
Pelzer, L., Pastushok, L., Moraes, T., Glover, J.N.M., Ellison, M.J., Ziola, B. and Xiao, W. (2009) Biological significance of structural differences between two highly conserved Ubc variants. Biochem. Biophy. Res. Comm. 378: 563-568. [Text]
Fu, Y., Pastushok, L. and Xiao, W. (2008) DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS Microbol. Rev. 32: 908-926. [Text]
Huen, M.S.Y., Yuan, J., Yamamoto, M., Akira, S., Ashley, C., Xiao, W. and Chen, J. (2008) Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol. Cell. Biol. 19: 6104-6112. [Text]
Anderson, H.J., Vonarx, E.J., Pastushok, L., Nakagawa, M., Katafuchi, A., Gruz, P., Di Rubbo, A., Grice, D.M., Osmond, M.J., Sakamoto, A., Nohmi, T., Xiao, W. and Kunz, B.A. (2008) Arabidopsis thaliana Y-family DNA polymerase η catalyses translesion synthesis and interacts functionally with PCNA2. Plant J. 55: 895-908. [Text]
Fu, Y., Zhu, Y. Zhang, K., Yeung, M., Durocher, D. and Xiao, W. (2008) Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell 133: 601-611. [Text]
Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76. [Text]
Rostek, C., Turner, E., Robbins, M., Rightnar, S., Xiao, W., Obenaus, A. and Harkness, T.A.A. (2008) Involvement of homologous recombination repair after proton-induced DNA damage. Mutagenesis 23: 119-129. [Text]
Brun, J., Chiu, R.K., Lockhart, K., Xiao, W., Wouters, B.G. and Gray, D.A. (2008) hMMS2 serves a redundant role in human PCNA polyubiquitination. BMC Mol. Biol. 9: 24. [Text]
Wen, R., Torres-Acosta, J.A., Pastushok, L., Lai, X., Pelzer, L., Wang, H. and Xiao, W. (2008) Arabidopsis UEV1D promotes lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell 20: 213-227. [Text]
Andersen, P.L., Xu, F. and Xiao, W. (2008) Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 18: 162-173. [Text]
Dworaczek, H. and Xiao, W. (2007) Xeroderma pigmentosum: a glimpse into nucleotide excision repair, genetic instability, and cancer. Crit. Rev. Oncogen. 13: 159-177. [Text]
Kunz, B.A. and Xiao, W. (2007) DNA damage tolerance in plants via translesion synthesis. Genes, Genomes, Genomics 1: 89-99. [Text]
Pastushok, L., Spyracopoulos, L. and Xiao, W. (2007) Two Mms2 residues cooperatively interact with ubiquitin and are critical for Lys63 polyubiquitination in vitro and in vivo. FEBS Lett. 581: 5343-5348. [Text]
Hanna, M., Ball, L.G., Tong, A.H., Boone, C. and Xiao, W. (2007) Pol32 is required for Polζ-dependent translesion synthesis and prevents double-strand breaks at the replication fork. Mutat. Res. 625: 164-176. [Text]
Mercier, P., Lewis, M.J., Hau, D.D., Saltibus, L.F., Xiao, W. and Spyracopoulos, L. (2007) Structure, interactions, and dynamics of the RING domain from human TRAF6. Protein Sci. 16: 602-614. [Text]
Barbour, L., Ball, L.G., Zhang, K. and Xiao, W. (2006) DNA damage checkpoints are involved in postreplication repair. Genetics 174: 1789-1800. [Text]
Syed, N.A., Andersen, P.L., Warrington, R.C. and Xiao, W. (2006) Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-κB activation. Apoptosis 11: 2147-2157. [Text]
Hau, D.D., Lewis, M.J., Saltibus, L.F., Pastushok, L., Xiao, W. and Spyracopoulos, L. (2006) Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. Biochemistry 45: 9866-9877. [Text]
Wen, R., Newton, L., Li, G., Wang, H. and Xiao, W. (2006) Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants. Plant Mol. Biol. 61: 241-253. [Text]
Fu, Y. and Xiao, W. (2006) Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Nucleic Acids Res. 34: 1876-1883. [Text]
Lewis, M.J., Saltibus, L.F., Hau, D.D., Xiao, W. and Spyracopoulos, L. (2006) Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human Mms2. J. Biomol. NMR 34: 89-100. [Text]
Barbour, L. and Xiao, W. (2006) Mating type regulation of cellular tolerance to DNA damage is specific to the DNA postreplication repair and mutagenesis pathway. Mol. Microbiol. 59: 637-650. [Text]
Andersen, P., Zhou, H., Pastushok, L., Moraes, T., McKenna, S., Ziola, B., Ellison, M.J., Dixit, V.M. and Xiao, W. (2005) Distinct regulation of Ubc13 functions by two Uev proteins Mms2 and Uev1A. J. Cell Biol. 170: 745-755. [Text]
Ball, L.G. and Xiao, W. (2005) Molecular basis of ataxia telangiestasia and related diseases. Acta Pharmacologica Sinica 26: 897-907. [Text]
Pastushok, L., Moraes, T.F., Ellison, M.J. and Xiao, W. (2005) A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. J. Biol. Chem. 280: 17891-17900. [Text]
Pastushok, L. and Xiao, W. (2004) DNA Postreplication repair modulated by ubiquitination and sumoylation. Advances in Protein Chemistry 69: 279-306. [Text]
Zhu, Y and Xiao, W. (2004) Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element. Nucleic Acids Res. 32: 5066-5075. [Text]
Wooff, J., Pastushok, L., Hanna, M., Yu, F. and Xiao, W. (2004) The TRAF6 RING finger domain mediates physical interaction with Ubc13. FEBS Lett. 566: 229-233. [Text]
Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W. and Dixit, V.M. (2004) Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature 427: 167-171. [Text]
Hanna, M.D., Meadows, K.L., Chow, B.L., Jinks-Robertson, S., Doetsch, P.W. and Xiao, W. (2004) Involvement of two endonuclease III homologs in the base excision repair for the processing of DNA alkylation damage in Saccharomyces cerevisiae. DNA Repair 3: 51-59 [Text]
Barbour, L. and Xiao, W. (2003) Regulation of alternative replication bypass pathways at stalled replication forks and its effects on genome stability: a yeast model. Mutat. Res. 532: 137-155. [Text]
Fu, Y. and Xiao, W. (2003) Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization. DNA Repair 2: 1435-1447 [Text]
Bawa, S. and Xiao, W. (2003) A single amino acid substitution in Msh5 results in DNA alkylation tolerance. Gene 315: 177-182. [Text]
Jia, X. and Xiao, W. (2003) Compromised DNA repair enhances sensitivity of the RNR3-lacZ genotoxic testing system. Toxicol. Sci. 75: 82-88. [Text]
McKenna, S., Hu, J., Moraes, T., Xiao, W., Ellison, M.J. and Spyracopoulos, L. (2003) Energetics and specificity of interactions within Ub.UEV.Ubc13 human ubiquitin conjugation complexes. Biochemistry 42: 7922-7930. [Text]
McKenna, S., Moraes, T., Pastushok, L., Ptak, C., Xiao, W., Spyracopoulos, L. and Ellison, M.J. (2003) An NMR based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2/Ubc13: The structural basis for lysine 63 chain catalysis. J. Biol. Chem. 278: 13151-13158. [Text]
Brown, M., Zhu, Y., Hemmingsen, S, and Xiao, W. (2002) Structural and functional conservation of error-free postreplication repair in Schizosaccharomyces pombe. DNA Repair 1: 869-880. [Text]
Jia, X., Zhu, Y. and Xiao, W. (2002) A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae. Mutat. Res. 519: 83-92. [Text]
Li, Z., Xiao, W., McCormick, J.J. and Maher, V.M. (2002) Identification of a protein essential for a major pathway used by human cells to avoid UV-induced DNA damage. Proc. Natl. Acad. Sci. USA 99: 4459-4464. [Text]
Ashley, C., Pastushok, L., McKenna, S., Ellison, M.J. and Xiao, W. (2002) Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Gene 285: 183-191. [Text]
Broomfield, S. and Xiao, W. (2002) Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free postreplication repair but not for damage induced mutagenesis. Nucleic Acids Res. 30: 732-739. [Text]
Hryciw, T., Tang, M., Fontanie, T. and Xiao, W. (2002) MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Mol. Genet. Genomics 266: 848-857. [Text]
Villalobo, E., Morin, L., Moch, C., Lescasse, R., Hanna, M., Xiao, W. and Baroin-Tourancheau, A. (2002) A homolog of CROC-1 in a ciliated protist (Sterkiella histriomuscorum) testifies to the ancient origin of the ubiquitin-conjugating enzyme variant family. Mol. Biol. Evol. 19: 39-48. [Text]
Xiao, W., Chow, B.L., Hanna, M. and Doetsch, P.W. (2001) Deletion of the MAG1 glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases. Mutat. Res. 487: 137-147. [Text]
McKenna, S., Spyracopoulos, L., Moraes, T., Pastushok, L., Ptak, C., Xiao, W. and Ellison, M.J. (2001) Non-covalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated poly-ubiquitination. J. Biol. Chem. 276: 40120-40126. [Text]
Zhu, Y. and Xiao, W. (2001) Two alternative cell cycle checkpoint pathways differentially control DNA damage induction of the yeast MAG1 and DDI1 expression. Mol. Genet. Genomics 266: 436-444. [Text]
Moraes, T.F., Edwards, R.A., McKenna, S., Pastushok, L., Xiao, W., Glover, J.N.M. and Ellison, M.J. (2001) Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. Nature Structural Biol. 8: 669-673. [Text]
Broomfield, S., Hryciw, T. and Xiao, W. (2001) DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat. Res. 486: 167-184. [Text]
Dai, H., Zhao, R., Haug, B., Hemmingsen, S.M. and Xiao, W. (2001) Isolation by phage display and characterization of a single-chain antibody specific for O6-methyldeoxyguanosine. Chinese Science Bulletin 46: 1024-1029. [Text]
Franko, J., Ashley, C. and Xiao, W. (2001) Molecular cloning and functional characterization of two murine cDNAs encoding Ubc-like proteins involved in DNA repair and mutagenesis. Biochem. Biophys. Acta. 1519: 70-77. [Text]
Barbour, L., Zhu, Y. and Xiao, W. (2000) Improving synthetic lethal screens by regulating the yeast centromere sequence. Genome 43: 910-917. [Text]
Xiao, W., Chow, B.L., Broomfield, S. and Hanna, M. (2000) The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways. Genetics 155: 1633-1641. [Text]
Brusky, J., Zhu, Y. and Xiao, W, (2000) UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae. Curr. Genet. 37: 168-174. [Text]
Chamankhah, M., Fontanie, T. and Xiao, W. (2000) The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions. Genetics 155: 569-576. [Text]
Xiao, W., Fontanie, T., Bawa, S. and Kohalmi, L. (1999) REV3 is required for spontaneous but not methylation damage-induced mutagenesis of Saccharomyces cerevisiae cells lacking O6-methylguanine DNA methyltransferase. Mutat Res. 431: 155-165. [Text]
Bawa S. and Xiao, W. (1999) Methionine reduces spontaneous and alkylation-induced mutagenesis in Saccharomyces cerevisiae cells deficient in O6-methylguanine-DNA methyltransferase. Mutat Res. 430: 99-107. [Text]
Xiao, W,. Chow, B.L., Fontanie, T., Ma, L., Bacchetti, S., Hryciw, T. and Broomfield, S. (1999) Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae. Mutat. Res. 431: 155-165. [Text]
Chamankhah, M. and Xiao, W. (1999) Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Res. 27: 2072-2079. [Text]
Chamankhah, M., Wei, Y.-F. and Xiao, W. (1998) Isolation of hMRE11B:failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225: 107-116. [Text]
Chamankhah, M. and Xiao, W. (1998) Molecular cloning and genetic characterization of the Saccharomyces cerevisiae NGS1/MRE11. Current Genet. 34: 368-374. [Text]
Zhu, Y. and Xiao, W. (1998) Differential regulation of two closely clustered yeast genes, MAG1 and DDI1, by cell-cycle checkpoints. Nucleic Acids Res. 26: 5402-5408. [Text]
Kunz, B.A., Henson, E.S., Karthikeyan, R., Kuschak, T., McQueen, S.A., Scott, C.A. and Xiao, W. (1998) Defects in base excisioin repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine. Envir. Mol. Mutag. 32: 173-178. [Text]
Ma, L., Broomfield, S., Lavery, C., Lin, S., Xiao, W. and Bacchetti, S. (1998) Up-regulation of CIR1/CROC-1 expression upon cell immortalization and in tumour-derived human cell lines. Oncogene 17: 1321-1326. [Text]
Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L. and Wei, Y.F. (1998) The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Nucleic Acids Res. 26: 3908-3914 [Text]
Xiao, W., Lechler, T., Chow, B.L., Fontanie, T., Agustus, M., Carter, K.C. and Wei, Y.-F. (1998) Identification, chromosomal mapping and tissue-specific espression of hREV3 encoding a putative human DNA polymerase ζ. Carcinogenesis 19: 945-949. [Text]
Xiao, W., Chow, B.L. and Milo, C.N. (1998) Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage. Mol. Gen. Genet. 257: 614-623. [Text]
Xiao, W. and Chow, B.L. (1998) Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage. Curr. Genet. 33: 92-99. [Text]
Broomfield, S., Chow, B.L. and Xiao, W. (1998) MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway. Proc. Natl. Acad. Sci. USA 95: 5678-2683. [Text]
Bawa, S. and Xiao, W. (1997) A mutation in the MSH5 gene results in alkylation tolerance. Cancer Res. 57: 2715-2720. [Text]
Liu, Y., Dai, H. and Xiao, W. (1997) UASMAG1, a yeast cis-acting element that regulates the expression of MAG1, is located within the protein coding region of DDI1. Mol. Gen. Genet. 255: 533-542. [Text]
Liu, Y. and Xiao, W. (1997) Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae. Mol. Microbiol. 23: 777-789. [Text]
Xiao, W., Chow, B.L. and Rathgeber, L. (1996) The repair of DNA methylation damage in Saccharomyces cerevisiae. Curr. Genet. 30: 461-468. [Text]
Xiao, W. and Rank, G.H. (1996) The 2μm plasmid of laboratory yeast strains is a type-1/type-2 hybrid. Yeast 12: 809-813. [Text]
Xiao, W., Nowak, M., Laferte, S. and Fontanie, T. (1996) Mutagenicity and toxicity of the DNA alkylation carcinogens 1,2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium. Mutagenesis 11: 241-245. [Text]
Xiao, W., Rathgeber, L., Fontanie, T. and Bawa, S. (1995) DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells. Carcinogenesis 16: 1933-1939. [Text]
Xiao, W. and Fontanie, T. (1995) Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant: its effects on both exogenous and endogenous DNA alkylation damage. Mutat. Res. 336: 133-142. [Text]
Xiao, W., Fontanie, T. and Tang, M. (1994) UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product. Yeast 10: 1497-1502. [Text]
Rank, G.H., Xiao, W. and Pelcher, L.E. (1994) Transpogenes: the transposition-like integration of short sequence DNA into the yeast plasmid creates the STB locus and plasmid-size polymorphism. Gene 147: 55-61. [Text]
Xiao, W., Penugonde, V. and Rank, G.H. (1994) The MAG1-3-methyladenine DNA glycosylase gene is closely linked to the SPT15 TATA-binding TFIID gene on chromosome V-R in Saccharomyces cerevisiae. Yeast 10: 687-691. [Text]
Rank, G.H., Xiao, W. and Arndt, G.M. (1994) Evidence for Darwinian selection of the 2μm plasmid STB locus in Saccharomyces cerevisiae. Genome 37: 12-18. [Text]
Xiao, W., Singh, K.K., Chen, B., Samson, L. (1993) A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 7213-7221. [Text]
Xiao, W. and Samson, L. (1993) In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl. Acad. Sci. USA 90: 2117-2121. [Text]
Xiao, W. and Rank, G.H. (1993) Polymorphism of 2μm plasmids in industrial strains of Saccharomyces cerevisiae. Appl. Microbiol. & Biotechnol. 39: 80-86. [Text]
Xiao, W. and Samson, L. (1992) The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions. Nucleic Acids Res. 20: 3599-3606. [Text]
Xiao, W., Derfler, B., Chen, J. and Samson, L. (1991) Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. EMBO J. 10: 2179-2186. [Text]
Rank, G.H. and Xiao, W. (1991) Alteration of industrial food and beverage yeasts by recombinant DNA technology. Ann. New York Acad. Sci. 646: 155-171.
Rank, G.H., Casey, G.P., Xiao, W. and Pringle, A.T. (1991) Polymorphism within the nuclear and 2μm genomes of Saccharomyces cerevisiae. Curr. Genet. 20: 189-194. [Text]
Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) Sequence diversity of yeast 2μm RAF gene and its coevolution with STB and REP1. Gene 101: 75-80. [Text]
Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) DNA sequence divergence and functional conservation at the STB locus of yeast 2μm circle variants. J. Bacteriol. 171: 1181-1186. []
Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) Evidence for cis- and trans-acting element coevolution of the 2μm circle genome in Saccharomyces cerevisiae. J. Mol. Evol. 32: 145-152. [Text]
Xiao, W., and Rank, G.H. (1990) Curing industrial Saccharomyces yeasts of parasitic 2μm plasmid. J. Am. Soc. Brew. Chem. 48: 107-110.
Xiao, W. and Rank, G.H. (1990) Branched chain amino acid regulation of the ILV2 locus in Saccharomyces cerevisiae. Genome 33: 596-603. [Text]
Xiao, W. and Rank, G.H. (1990) Cloning of industrial Saccharomyces 2μm plasmid variants by in vivo site-specific recombination. Plasmid 23: 67-70. [Text]
Xiao, W. and Rank, G.H. (1990) An improved method for yeast 2μm plasmid curing. Gene 88: 241-245. [Text]
Xiao, W. and Rank, G.H. (1989) The construction of recombinant industrial yeasts free of bacterial sequences by direct gene replacement into a nonessential region of the genome. Gene 76: 99-107. [Text]
Rank, G.H., Arndt, G. and Xiao, W. (1989) FLP-FRT mediated intra-chromosomal recombination on a tandemly duplicated YEp integrant at the ILV2 locus of chromosome XIII in S. cerevisiae. Curr Genet. 15: 107-112. [Text]
Xiao, W. and Rank, G.H. (1988) The yeast ILV2 gene is under general amino acid control. Genome 30: 984-986. [Text]
Rank, G.H., Casey, G. and Xiao, W. (1988) Gene transfer in industrial Saccharomyces yeasts. Food Biotechnol. 2: 1-41.
Xiao, W. (1988) Stability of cloned Brassica napus chloroplast DNA fragments in the cyanobacterium Anacystis nidulans R2. Mol. Gen. Genet. 214: 307-312.
Casey, G.P., Xiao, W. and Rank, G.H. (1988) Construction of α-galactosidase-positive strains of industrial baker's (Saccharomyces cerevisiae) yeasts. J. Am. Soc. Brew. Chem. 46: 67-71.
Casey, G.P., Xiao, W. and Rank, G.H. (1988) Application of pulsed field chromosome electrophoresis in the study of chromosome XIII and the electrophoretic karyotype of industrial strains of Saccharomyces yeasts. J. Inst. Brew. 94: 239-243.
Rank, G.H., Xiao, W., Kolenovsky, A. and Arndt, G. (1988) FLP recombinase induction of the breakage-fusion-bridge cycle and gene conversion in Saccharomyces cerevisiae. Curr. Genet. 13: 273-281.
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