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高明遠檢視原始碼討論檢視歷史

事實揭露 揭密真相
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高明遠
國籍 中國
職業 中國科學院化學研究所研究、教授

高明遠中國科學院化學研究所研究員(Institute of Chemistry, CAS),博士生導師。中科院百人計劃入選者,國家傑出青年基金獲得者,973首席科學家。現任中國研究型醫院學會腫瘤影像診斷學專業委員會常委,上海市分子影像學重點實驗室、中國醫學科學院醫學影像研究中心、天津市功能影像重點實驗室、江蘇省分子影像與功能影像重點實驗室、分子影像湖北省重點實驗室學術委員會副主任及委員。先後主持國家重點研發專項項目1項,國家重點基礎研究發展計劃(973計劃)項目1項,863項目2項,基金委化學部傑出青年基金項目1項,基金委醫學部重大項目子課題1項,基金委醫學部重點項目1項,基金委重大國際合作項目2項(化學部和醫學部)。[1]

學習經歷

1985-1989年 吉林大學化學系高分子專業,本科生 1989-1992年 吉林大學化學系高分子專業,碩士研究生 1992-1995年 吉林大學化學系高分子專業,博士研究生,獲得理學博士學位(論文導師:沈家驄院士)

人物經歷

1996年獲得德國洪堡獎學金,在馬普膠體界面所從事博士後工作; 1999年起在慕尼黑大學物理系任項目負責人; 2001年入選中科院「百人計劃」,任化學所研究員博士生導師; 2002年入選德國CIM人才回歸計劃; 2002年獲得國家傑出青年基金; 2005年獲「百人計劃」終期評估優秀; 2006年起享受國務院政府津貼; 分別於2003年起和2008年起擔任《科學通報》的特約編輯和編委; 2011年起擔任「納米研究」國家重大科學研究計劃項目首席科學家;2012年起任國家自然科學基金委第十四屆專家評審組成員。 2014 年獲得北京市科學技術獎一等獎(第一完成人)。

研究方向

(1)功能無機納米晶體的液相控制合成; (2)無機納米晶體的光學性質及磁學性質研究; (3)無機納米晶體在疾病診斷中的應用研究; (4)無機納米晶體在生物分析中的應用研究; (5)有機/無機納米晶體功能雜化材料的結構設計與性質研究。

主要貢獻

1、在JACS, Angew Chem Int Edit, Adv Mater, ACS Nano, Biomaterials等期刊发表学术论文100多篇,论文被引用5200多次;
2、申请发明专利14 项,12项获得授权,6项成功转让。
3、在Chem. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed.,Adv. Mater., Nat. Comm.,Biomaterials等学术期刊上共发表学术论文160+篇,累计影响因子总和>1000+,影响因子大于10的论文65篇,累积引用14700+次。
4、撰写中英文专著3章1部。
5、组织境内外学术会议10+次,应邀参加学术会议做特邀及邀请报告180+次。
6、目前担任Current Pharmaceutical Design,Advanced Theraputics等期刊的编辑或国际顾问编委。

[2]

獲獎記錄

2006 -: 享受國務院特殊津貼; 2005: 中科院「百人計劃」終期評估優秀獎; 2002: 國家傑出青年基金獲得者(化學學部); 2001: 中國科學院「百人計劃」入選者; 2001: 德國「CIM人才回歸計劃」獲得者; 1997: 德國洪堡獎學金; 1996: 馬普學會獎學金; 1995: 英國皇家學會獎學金,放棄。


代表性論文:

       1.Coordinatively Unsaturated Fe3+ Based Activable Probes for Enhanced MRI and Therapy of Tumors

Peisen Zhang, Yi Hou*, Jianfeng Zeng, Yingying Li, Zihua Wang, Ran Zhu, Tiancong Ma, and Mingyuan Gao* Angew. Chem. Int. Ed., 2019, DOI: 10.1002/anie.201904880.

       2. Multispectral Upconversion-Optoacoustic Imaging of Redox Correlation for Dynamic Profiling of Inflammation Progression

Xiangzhao Ai‡, Zhimin Wang‡, Yong Wang, Ruochong Zhang, Jun Lin, Yuanjing Zheng, Mingyuan Gao*, Bengang Xing* Nat. Comm., 2019, 10, 1087.

       3. Quantitatively Visualizing Tumor-related Protease Activity In Vivo Using A Ratiometric Photoacoustic Probe

Ling Yin, Hao Sun, Hao Zhang, Lei He, Ling Qiu, Jianguo Lin, Huawei Xia, Yuqi Zhang, Shunjun Ji, Haibin Shi*, Mingyuan Gao* J. Am. Chem. Soc., 2019, 141(7), 3265-3273.

       4. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in vivo

Tiancong Ma‡, Yi Hou‡, Jianfeng Zeng‡, Chunyan Liu, Peisen Zhang, Lihong Jing, Dihua Shangguan, and Mingyuan Gao* J. Am. Chem. Soc., 2018, 140(1), 211-218.

       5. Tumor Microenvironment-Triggered Aggregation of Anti-Phagocytosis 99mTc-Labelled Fe3O4 Nanoprobes for Enhanced Tumor Imaging in Vivo

Zhenyu Gao‡, Yi Hou‡, Jianfeng Zeng, Lei Chen, Chunyan Liu, Wensheng Yang*, and Mingyuan Gao* Adv. Mater., 2017, 29(24), 1701095.

       6. Molecular Imaging of Vulnerable Atherosclerotic Plaques In Vivo with Osteopontin-Specific Upconversion Nanoprobes

Ruirui Qiao‡, Hongyu Qiao‡, Yan Zhang, Yabin Wang, Chongwei Chi, Jie Tian, Lifang Zhang, Feng Cao*, and Mingyuan Gao* ACS Nano, 2017, 11(2), 1816-1825.

       7. Light-triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

Xiaju Cheng, Rui Sun, Ling Yin, Zhifang Chai, Haibin Shi*, and Mingyuan Gao* Adv. Mater., 2017, 29(6), 1604894.

       8. Aqueous Based Semiconductor Nanocrystals

Lihong Jing‡, Stephen V. Kershaw‡, Yilin Li, Xiaodan Huang, Yingying Li, Andrey L. Rogach*, and Mingyuan Gao* Chem. Rev., 2016, 116(18), 10623-10730.

       9. Graphene Oxide-based Sensor for Ultrasensitive Visual Detection of Fluoride

Tapas K. Manda‡, Yi Hou‡, Zhenyu Gao, Haoran Ning, Wensheng Yang, and Mingyuan Gao* Adv. Sci., 2016, 3(12), 1600217.

       10. Ultrasmall Biocompatible WO3-x Nanodots for Multi-modality Imaging and Combined Therapy of Cancers

Ling Wen, Ling Chen, Shimin Zheng, Jianfeng Zeng, Guangxin Duan, Yong Wang, Guanglin Wang, Zhifang Chai, Zhen Li*, Mingyuan Gao* Adv. Mater., 2016, 28(25), 5072-5079.

       11. Protease-Activated Ratiometric Fluorescent Probe for pH Mapping of Malignant Tumors

Yi Hou, Jin Zhou, Zhenyu Gao, Xiaoyu Sun, Chunyan Liu, Dihua Shangguan, Wensheng Yang, and Mingyuan Gao* ACS Nano, 2015, 9(3), 3199-3205.

       12. Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles

Ruirui Qiao‡, Changhao Liu‡, Muhan Liu, Hao Hu, Chunyan Liu, Yi Hou, Kaichun Wu*, Yenan Lin, Jimin Liang, Mingyuan Gao* ACS Nano, 2015, 9(2), 2120-2129.

       13. Insight into Strain Effects on Band Alignment Shifts, Carrier Localization and Recombination Kinetics in CdTe/CdS Core/Shell Quantum Dots

Lihong Jing‡, Stephen V. Kershaw‡, Tobias Kipp‡, Sergii Kalytchuk, Ke Ding, Jianfeng Zeng, Mingxia Jiao, Xiaoyu Sun, Alf Mews, Andrey L. Rogach, and Mingyuan Gao* J. Am. Chem. Soc., 2015, 137(5), 2073-2084.

       14.Magnetically Engineered Semiconductor Quantum Dots as Multimodal Imaging Probes

Lihong Jing, Ke Ding, Stephen V. Kershaw, Ivan M. Kempson, Andrey L. Rogach*, and Mingyuan Gao* Adv. Mater., 2014, 26(37), 6367-6386.

       15. Are Rare-Earth Nanoparticles Suitable for In Vivo Applications?

Chunyan Liu, Yi Hou, and Mingyuan Gao* Adv. Mater., 2014, 26(40), 6922-6932.

       16. Anchoring Group Effects of Surface Ligand on Magnetic Properties of Fe3O4 Nanoparticles: Towards High Performance MRI Contrast Agents

Jianfeng Zeng, Lihong Jing, Yi Hou, Mingxia Jiao, Ruirui Qiao, Qiaojuan Jia, Chunyan Liu, Fang Fang, Hao Lei, and Mingyuan Gao* Adv. Mater., 2014, 26(17), 2694-2698.

       17.Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo

Chunyan Liu, Zhenyu Gao, Jianfeng Zeng, Yi Hou*, Fang Fang, Yilin Li, Ruirui Qiao, Lin Shen, Hao Lei, Wensheng Yang, and Mingyuan Gao* ACS Nano, 2013, 7(8), 7227-7240.

       18. NaGdF4 Nanoparticle-Based Molecular Probes for Magnetic Resonance Imaging of Intraperitoneal Tumor Xenografts In Vivo

Yi Hou, Ruirui Qiao, Fang Fang, Xuxia Wang, Chengyan Dong, Kan Liu, Chunyan Liu, Zhaofei Liu, Hao Lei*, Fan Wang, and Mingyuan Gao* ACS Nano, 2013, 7(1), 330-338.

       19. Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood-Brain Barrier

Ruirui Qiao, Qiaojuan Jia, Sabine Hüwel, Rui Xia, Ting Liu, Fabao Gao*, Hans-Joachim Galla*, and Mingyuan Gao* ACS Nano, 2012, 6(4), 3304-3310.

       20. Gelification: An Effective Measure for Achieving Differently Sized Biocompatible Fe3O4 Nanocrystals through a Single Preparation Recipe

Qiaojuan Jia, Jianfeng Zeng, Ruirui Qiao, Lihong Jing, Liang Peng, Fenglong Gu*, and Mingyuan Gao* J. Am. Chem. Soc., 2011, 133(48), 19512-19523.

參考資料