戴建武
戴建武， 男，博士，1965年生。研究员，博士生导师，2001年入选中国科学院的"百人计划"[1]，任中国科学院遗传与发育生物学研究所组织工程研究实验室主任。CCTV2014年度科技创新人物候选人。
| 戴建武 | |
|---|---|
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研究员，博士生导师 | |
| 出生 | 1965年 |
| 国籍 | 中国 |
| 职业 | 教育科研工作者 |
目录
人物简介
戴建武 男，博士，1965年生。研究员，博士生导师[2]。
1988 年武汉大学生物系学士，1991年北京医科大学细胞生物学系硕士，并留校任教。1998年杜克大学（Duke University）医学中心理学博士。2000年在哈佛大学医学院完成博士后训练。2001年入选中国科学院的"百人计划"，任中国科学院遗传与发育生物学研究所组织工程研究实验室主任[3]。
主要研究
戴建武，现任中国科学院遗传与发育生物学研究所研究员、再生医学研究中心主任；中国科学院苏州纳米与仿生技术研究所客座研究员。戴建武研究员发明了能与组织再生因子特异结合以及与干细胞特异结合的两大类功能生物材料构建技术，解决了组织器官再生微环境构建中的“再生因子空间定位、浓度维持”和“细胞空间定位、干细胞选择性利用”两大技术难题。他提出了脊髓损伤激活的内源干细胞向神经细胞定向分化是脊髓损伤修复的重要机制，并认为该机制也是其它组织器官再生的重要机制。在国际学术期刊发表论文近200篇。由于在子宫内膜再生转化研究的突出贡献，戴建武研究员2014年被评为CCTV-年度十大科技创新人物。在心肌再生研究中获国家科学技术进步奖二等奖1项，2016年获中国侨界再生医学创新成果贡献奖。他是中科院干细胞与再生医学研究战略先导专项“人工组织器官构建”项目首席科学家，中科院干细胞与再生医学重点布局项目首席科学家，国家出生缺陷再生修复产品研发重大专项首席科学家。他的团队在2015年率先开始的神经再生支架结合干细胞修复脊髓损伤的临床研究受到广泛关注，2016年应邀在瑞典欧洲再生医学年会做大会报告和2017年应邀在瑞士举行的欧洲再生医学年会做主题报告。他领导的包括子宫内膜、脊髓及心肌等多个组织器官再生修复的临床研究引领了再生医学产品研发的方向。
报告题目：
再生医学的关键技术的研发及其转化研究
报告人及单位：
戴建武 中国科学院遗传与发育生物学研究所再生医学研究中心
报告摘要：
基于生物材料、干细胞及组织再生因子的再生医学是现代医学的重要分支。再生医学的发展有望能解决人类目前医疗技术不能有效治疗的许多重大疾病，并且在不远的将来可以实现人体器官制造，为人类提供器官置换的零部件。再生医学的核心技术是重建组织器官发育过程的微环境。这个微环境要实现干细胞及各种组织再生因子的空间定位及提供细胞生长与分化的条件。我们通过组织再生因子特异结合以及与干细胞特异结合的两大类功能生物材料构建技术，解决了组织器官再生微环境构建中的“再生因子空间定位、浓度维持”和“细胞空间定位、干细胞选择性利用”两大技术难题。通过不同动物模型，证实了这类智能型生物材料可以有效引导不同组织器官的再生。本报告将通过女性生殖系统、心肌、肺及脊髓神经等组织再生的转化研究，系统介绍再生医学的关键技术及其转化研究中的细节，和大家一起分享再生医学的今天与明天。
个人成就
戴建武博士领导的创新组的主要研究方向为组织工程的研究及产品开发。并不断将成果转化成产品推向市场。主要研究内容:
1.关于基因载体及其用于组织再生的研究
主要是筛选出具有组织特异性的基因载体，用于特异性组织修复。在1-2年内摸索出一个可以用于特异性组织损伤修复的方法。
2. 组织工程材料的研究
摸索出适用于不同组织及器官的组织工程的材料。包括比较不同的化学合成材料，选择最佳的强度及可塑性;比较不同的生物合成材料，选择最佳的强度及可塑性;复合材料的构建及测试及动物模型实验等。
3. 干细胞分化与组织工程
开展人干细胞分化机理的研究,探索体外组织及器官再生。
主要文章
1.Li, X., Li, M., Sun, J., Zhuang, Y., Shi, J., Guan, D., Chen, Y., Dai, J.*. Radially Aligned Electrospun Fibers with Continuous Gradient of SDF1α for the Guidance of Neural Stem Cells. Small
2.Gao, J., He, Y., Zhao, X., Ran, X., Wu, Y., Su, Y., Dai, J.*. Single step synthesis of amine-functionalized mesoporous magnetite nanoparticles and their application for copper ions removal from aqueous solution
3.Lv, D., Yu, S., Ping, Y., Wu, H., Zhao, X., Zhang H., Cui, Y., Chen, B., Zhang, X., Dai, J., Bian, X.*, Yao X.*. A three-dimensional collagen scaffold cell culture system for screening anti-glioma therapeutics
4.Xiao, Z., Tang, F., Tang, J., Yang, H., Zhao, Y., Chen, B., Han, S., Wang, N., Li, X., Cheng S., Han, G., Zhao, C., Yang, X., Chen, Y., Shi, Q., Hou, S.,Zhang, S., Dai, J.*.One-year clinical study of NeuroRegen scaffold implantation following scar resection in complete chronic spinal cord injury patients
5.Han, J., Dai J.*.Microgravity may help future organ/tissue manufacture. Sci China Life Sci
6. Sun, J., Zhao, Y., Li, Q., Chen, B., Hou, X., Xiao, Z., Dai, J.*.Controlled Release of Collagen-Binding SDF-1α Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells
7. Hou, X., Shi, C., Chen, W., Chen, B., Jia, W., Guo, Y., Ma, C., Ye, G., Kang, J., Dai J.*.Transplantation of human adipose-derived mesenchymal stem cells on a bladder acellular matrix for bladder regeneration in a canine model. Biomed Mater
8. Ma, Y., Wang, H., Yan, D., Wei, Y., Cao Y., Yi, P., Zhang, H., Deng, Z., Dai J., Liu X., Luo J., Zhang Z., Sun S., Guo H.. Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2
9. Wang, X.*, Zhang, Q., Zou, L., Hu, H., Zhang, M., Dai, J.*. Facile-synthesized ultrasmall CuS nanocrystals as drug nanocarriers for highly effective chemo–photothermal combination therapy of cancer
10. Su, J., Ding, L., Cheng, J., Yang, J., Li, X., Yan, G., Sun, H., Dai, J.*, Hu Y.*.Transplantation of adipose-derived stem cells combined with collagen scaffolds restores ovarian function in a ratmodel of premature ovarian insufficiency
11. Han, S., Wang, B., Li, X., Xiao, Z., Han, J., Zhao, Y., Fang, Y., Yin, Y., Chen, B., Dai J.*.Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation
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戴建武研究员做研究所重大突破报告 |
12. Cui, Y., Han, J., Xiao, Z., Chen, T., Wang, B., Chen, B., Liu, S., Han, S., Fang, Y., Wei, J., Wang, X., Ma, X.*, Dai, J.*. The miR-20-Rest-Wnt signaling axis regulates neural progenitor cell differentiation
13. Liang, H., Li, X., Wang, B., Chen, B., Zhao, Y., Sun, J., Zhuang, Y., Shi, J., Shen, H., Zhang, Z., Dai, J.*. A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix
14. Ma, Y., Wang, H., Yan, D., Wei, Y., Cao, Y., Yi, P., Zhang, H., Deng, Z., Dai, J., Liu X., Luo J., Zhang, Z., Sun, S., Guo, H.. Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2
15. Du, M., Chen, B., Meng, Q., Liu, S., Zheng, X., Zhang, C., Wang, H., Li, H., Wang, N., Dai, J.*. 3D bioprinting of BMSC-laden methacrylamide gelatin scaffolds with CBD-BMP2-collagen microfibers
16. Kou, D., Du, M., Hou, X., Chen, B., Li, X., Fang, Y., Zhao, Y., Wang, H.*, Wang, L.*, Dai, J.*. Centimeter-sized biomimetic bone constructs fabricatedviaCBD-BMP2-collagen microcarriers and BMSC-gelatin microspheres
17. Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Li, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.*. Functionalized collagen scaffold implantation and cAMP administration collectively facilitate spinal cord regeneration
18. Shen, H., Ma, Y., Luo, Y., Liu, X., Zhang, Z.*, Dai, J.* Directed osteogenic differentiation of mesenchymal stem cell in three-dimensional biodegradable methylcellulose-based scaffolds
19. Jia, W., Tang, H., Wu, J., Hou, X., Chen, B., Chen, W., Zhao, Y., Shi, C., Zhou, F., Yu, W., Huang, S., Ye, G., Dai, J.*. Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model
20. Li, X., Li, H., Sun, J., Zhuang, Y., Xu, B., Dai, J.*. Electrospun Collagen Fibers with Spatial Patterning of SDF1α for the Guidance of Neural Stem Cells
21. Wu, J., Jia, W., Chen, W., Zhou, F., Fang, Z., Xianglin Hou, X., Chen, B., Ye, G.*, Da, J.*. Transplantation of hBMSCs Loaded on Collagen Scaffolds for the Regeneration of Canine Tissue-Engineered Urethras
22. Yang, Y., Shi, C., Hou, X., Zhao, Y., Chen, B., Tan, B., Deng, Z., Li, Q., Liu, J., Xia, Z., Miao, Q., Dai, J.*. Modified VEGF targets the ischemic myocardium and promotes functional recovery after myocardial infarction
23. Li, X., Han, J., Zhao, Y., Ding, W., Wei, J., Han, S., Shang, X., Wang, B., Chen, B., Xiao, Z., Dai, J.*. Functionalized Collagen Scaffold Neutralizing the Myelin-Inhibitory Molecules Promoted Neurites Outgrowth in Vitro and Facilitated Spinal Cord Regeneration in Vivo
24. Liang, H., Li, X., Chen, B., Wang, B., Zhao, Y., Zhuang, Y., Shen, H., Zhang, Z., Dai, J.*. A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy
25. Luo, Y.,Shen, H.,Fang, Y.,Cao, Y.,Huang, J.,Zhang, M.,Dai, J.,Shi, X.,Zhang, Z.*.Enhanced proliferation and osteogenic differentiation of mesenchymal stem cells on graphene oxide-incorporated electrospun poly (lactic-co-glycolic acid) nanofibrous mats
26. Han, S.,Wang, B.,Jin, W.,Xiao, Z.,Li, X.,Ding, W.,Kapur, M.,Chen, B.,Yuan, B.,Zhu, T.,Wang, H.,Wang, J.,Dong, Q.,Liang, W.,Dai, J.*. The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canine
27. Lu, C.,Meng, D.,Cao, J.,Xiao, Z.,Cui, Y.,Fan, J.,Cui, X.,Chen, B.,Yao, Y.,Zhang, Z.,Ma, J.,Pan, J.*,Dai, J.*. Collagen scaffolds combined with collagen-binding ciliary neurotrophic factor facilitate facial nerve repair in mini-pigs
28. Tao, L., Li, Q., Ren, H., Chen, B., Hou, X., Mou, L., Zhou, S., Zhou, J., Sun, X., Dai, J.*, Ding, Y.*. Repair of Extrahepatic Bile Duct Defect Using a Collagen Patch in a Swine Model
29. Shen, Q.,Chen, B.,,Xiao, Z.,,Zhao, L.,Xu, X.,Wan, X.,Jin, M.,Dai, J.*,Dai, H.*, Paracrine factors from mesenchymal stem cells attenuate epithelial injury and lung fibrosis
30. Song, T.,Zhao, X.,Sun, H.,Li, X.,Lin, N.,Ding, L.,Dai, J.,Hu, Y.*. . Regeneration of uterine horns in rats using collagen scaffolds loaded with human embryonic stem cell-derived endometrium-like cells
31. Guan, J.,Zhang, B.,Zhang, J.,Ding, W.,Xiao, Z.,Zhu, Z.,Han, Q.,Wu, C.,Sun, Y.,Tong, W.,Dai, J.*,Wang, R.*. Nerve regeneration and functional recovery by collagen-binding BDNF in an intracerebral hemorrhage model
32. Han, S.,Wang, B.,Jin, W.,Xiao, Z.,Chen, B.,Xiao, H.,Ding, W.,Cao, J.,Ma, F.,Li, X.,Yuan, B.,Zhu, T.,Hou, X.,Wang, J.,Kong, J.,Liang, W.*,Dai, J.*.The collagen scaffold with collagen binding BDNFenhances functional recovery by facilitating peripheral nerve infiltrating and ingrowth in canine complete spinal cord transaction
33. Wang, H.,Yan, X.,Shen, L.,Li, S.,Lin, Y.,Wang, S.,Hou X.,Shi, C.,Yang Y.,Dai, J.*, Tan, Q.*.Acceleration of wound healing in acute full-thickness skin wounds using a collagen-binding peptide with an affi nity for MSCs
34. Ma, F., Xiao, Z., Meng, D., Hou, X., Zhu, J., Dai, J.*, Xu, R.*.Use of natural neural scaffolds consisting of engineered vascular endothelial growth factor immobilized on ordered collagen fibers filled in a collagen tube for peripheral nerve regeneration in rats
35. Hu, W.,Zhao, J.,Long, M.,Zhang, X., Liu, Q.,Hou, M., Kang, Q.,Wang, Y.,Xu, S., Kong, W., Zhang, H.,Wang, S.,Sun, Y., Hang, H.,Huang, Y., Cai, W., Zhao, Y.,Dai, J.,Zheng, H.,Duan, E.,Wang J
36. Cao, Y.,Ma, Y.,Zhang. M.,Wang, H.,Tu, X.,Shen, H.,Dai, J.,Guo, H.*, Zhang, Z.*. Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice
37. Wang, B.,Liu, T.,Lai, CH.,Rao, Y.,Choi, MC.,Chi, JT..,Dai, J.,Rathmell, JC.,Yao, TP.*. Glycolysis-dependent Histone Deacetylase 4 degradation regulates inflammatory cytokine production
38. Zhang, J.,Zhao, Y.,Hou, X.,Chen, B.,Xiao, Z.,Han, J.,Shi, C.,Liu, J.,Miao, Q.,Dai, J.*. The inhibition effects of insulin on BMP2-induced muscle heterotopic ossification
39. Lv, Q.,Lan, W.,Sun, W.,Ye, R.,Fan, X.,Ma, M.,Yin, Q.,Jiang, Y.,Xu, G.,Dai, J.,Guo, R.*,Liu, X.*. Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats
40. Wei, J.,Han, J.,Zhao, Y.,Cui, Y.,Wang, B.,Xiao, Z.,Chen, B.,Dai, J.*. The importance of three-dimensional scaffold structure on stemness maintenance of mouse embryonic stem cells
41. Cui, Y.,Lu, C.,Meng, D.,Xiao, Z.,Hou, X.,Ding, W.,Kou, D.,Yao, Y.,Chen, B.,Zhang, Z.,Li, J.,Pan, J.*,Dai, J.*.Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs
42. Han, X.,Zhang, W.,Gu, J.,Zhao, H.,Ni, L.,Han, J.,Zhou, Y.,Gu, Y.,Zhu, X.,Sun, J.,Hou, X.,Yang, H.,Dai, J.*,Shi, Q.*.Accelerated postero-lateral spinal fusion by collagen scaffolds modified with engineered collagen-binding human bone morphogenetic protein-2 in rats
43. Ding, W.,Dai, J..Methods for detecting transcribed pseudogenes: PCR on regions of high sequence similarity followed by cloning and sequencing
44. Wu, L.Xu, L.,Xu, X.,Fan, X.,Xie, Y.,Yang, L.,Lan, W.,Zhu, J.,Xu, G.,Dai, J.,Jiang, Y.,Liu, X.*.Keepwarmandgetsuccess: theroleofpostischemictemperaturein themousemiddlecerebralarteryocclusionmodel
45. Liu, X.,Li, X.,Li, S.,Zhou, X.,Li, S.,Wang, Q.,Dai, J.,Lai, R.,Xie, L.,Zhong, M.,Zhang, Y.,Zhou, L...An in vitro study of a titanium surface modified by simvastatin-loaded titania nanotubes-micelles
46. Chong, Y., Ma, Y., Shen, H., Tu, X., Zhou, X., Xu J., Dai, J., Fan, S.*, Zhang, Z.*, The invitro and invivo toxicity of graphene quantum dots
47. Ding L., Li, X., Sun, H., Su, J., Lin, N., Péault, B., Song, T., Yang, J., Dai, J.*, Hu, Y.*, Transplantation of bone marrow mesenchymal stem cells on collagen scaffolds for the functional regeneration of injured rat uterus
48. Ma, F.,Xiao, Z.,Chen, B.,Hou X.,Han, J.,Zhao, Y.,Dai, J.*,Xu, R.*. Accelerating proliferation of neural stem/progenitor cells in collagen sponges immobilized with engineered basic fibroblast growth factor for nervous system tissue engineering
49. Du, M.,Liang, H.,Mou, C.,Li, X.,Sun, J.,Zhuang, Y.,Xiao, Z.,Chen, B.,Dai, J.*. Regulationofhumanmesenchymalstemcellsdifferentiationintochondrocytesinextracellularmatrix-basedhydrogelscaffolds
50. Cao, L., Li, B., Yi, P., Zhang, H., Dai, J., Tan, B.*, Deng, Z.* The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides
51. Shi, Q.,Gao, W.,Han, X.,Zhu, X.,Sun, J.,Xie, F.,Hou, X.,Yang, H.,Dai, J.*,Chen, L.*, Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model
52. Wu, L.,Xu, L.,Xu, X.,Fan, X.,Xie, Y.,Yang, L.,Lan, W.,Zhu, J.,Xu, G.,Dai, J.,Jiang, Y.,Liu, X.*, Keep warm and get success: The role of postischemic temperature in the mouse middle cerebral artery occlusion model
53. Cui, Y., Xiao, Z., Chen, T., Wei, J., Chen, L., Liu, L., Chen, B., Wang, X., Li, X., Dai, J*. The miR-7 identified from collagen biomaterial based 3-D cultured cells regulates neural stem cell differentiation
54. Han, Q.,Zhan, B.,Chen, B.,Dai, J.,Xu, J.,Wang, C.,Wang, Z. * . Evaluationof abioactivebone-inducingmaterialconsistingofcollagenscaffolds andcollagen-binding BMP2
55. Yang, Y.,Yu, K.,Zhang, H.,Dai, J.,Deng, Z., In vitro assessment of the dual-targeting behavior of a peptide-based magnetic resonance imaging contrast agent
56. Ma, F.,Xiao, Z.,Chen, B.,Hou, X.,Dai, J.*,Xu, R.*. Linear ordered collagen scaffolds loaded with collagen-binding basic fibroblast growth factor facilitate recovery of sciatic nerve injury in rats
57. Huang, X.,Li, X.,Wang, Q.,Dai, J.,Hou, J.*,Chen, L.*. Single-molecule level binding force between collagen and collagen binding domain-growth factor conjugates
58. Du, M., Liang, H., Mou, C., Li, X., Sun, J., Zhuang, Y., Xiao, Z., Chen, B., Dai, J.*,Regulation of human mesenchymal stem cells differentiation into chondrocytes in extracellular matrix-based hydrogel scaffolds
59. Han, J., Chen, L., Luo, G., Dai, B., Wang, X., Dai, J.*. Three-dimensional culture may promote cell reprogramming
60. Jiang, Y., Chen, B., Liu, Y., Zhufu, Z., Yan, X., Hou, X., Dai, J.*, Tan, Q*. Effect of collagen scaffold with adipose-derived stromal vascular fraction cells on diabetic wound healing: A study in a diabetic porcine model
61. Du, M., Zhu, Y., Yuan, L., Liang, H., Mou, C., Li, X., Sun, J., Zhuang, Y., Zhang, W., Shi, Q., Chen, B., Dai, J.* Assembled 3D cell niches in chitosan hydrogel network to mimic extracellular matrix
62. Guan, J., Zhu, Z., Robert Zhao C., Xiao, Z., Wu, C., Han, Q., Chen, L., Tong, W., Zhang, J., Han, Q., Gao, J., Feng, M., Bao, X., Dai, J.*, Wang, R.*, Transplantation of human mesenchymal stem cells loaded on collagen scaffolds for the treatment of traumatic brain injury in rats
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戴建武在发布会上介绍情况 |
63. Su, G., Zhao, Y., Wei, J., Xiao, Z., Chen, B., Han, J., Chen, L., Guan, J., Wang, R., Dong, Q., Dai, J. *. Direct conversion of fibroblasts into neural progenitor-like cells by forced growth into 3D spheres on low attachment surfaces
64. Li, X., Xiao, Z., Han, J., Chen, L., Xiao, H., Ma, F., Hou, X., Li, X., Sun, J., Ding, W., Zhao, Y., Chen, B., Dai, J.*, Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair
65. Tan, Q., Chen, B., Yan, X., Lin, Y., Xiao, Z., Hou, X. and Dai, J.*. Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in diabetic rat model
66. Li, N., Zhang, Q., Gao, S., Song, Q., Huang, R., Wang, L., Liu, L., Dai, J.* Tang, M.* Cheng, G.* Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells
67. Su, G., Zhao, Y., Wei, J., Han, J., Chen, L., Xiao, Z., Chen, B. and Dai, J. *. The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties. Biomaterials
68. Yi, P., Chen, G., Zhang, H., Tian, F, Tan, B., Dai, J., Wang, Q.,* Deng, Z.*. Magnetic resonance imaging of Fe3O4@SiO2-labeled human mesenchymal stem cells in mice at
69. Han, J.,Xiao, Z.,Chen, L.,Chen, B.,Li, X.,Han, S.,Zhao, Y.,Dai, J.*. Maintenance of the self-renewal properties of neural progenitor cells cultured in three-dimensional collagen scaffolds by the REDD1-mTOR signal pathway
70. Cao, J., Xiao, Z., Jin, W., Chen, B., Meng, D., Ding, W., Han, S., Hou, X., Zhu, T., Yuan, B., Wang, J., Liang, W., and Dai, J.*. Induction of rat facial nerve regeneration by functional collagen scaffolds
71. Shen, H., Liu, M., He, H., Zhang, L., Huang, J., Chong, Y., Dai, J., and Zhang Z. *. PEGylated graphene oxide-mediated protein delivery for cell function regulation
72. Chen, W., Cao, Y., Liu, M., Zhao, Q., Huang, J., Zhang, H., Deng, Z., Dai, J., Williams, DF., Zhang, Z. *. Rotavirus capsid surface protein VP4-coated Fe3O4 nanoparticles as a theranostic platform for cellular imaging and drug delivery
73. Han, S., Zhao, Y.,Xiao, Z.,Han, J.,Chen, B.,Chen, L. Dai, J. *. The three-dimensional collagenscaffoldimprovesthestemnessof rat bone marrow mesenchymalstemcells
74. Li, Q., Tao, L., Chen, B., Ren, H., Hou, X., Zhou, S., Zhou, J., Sun, X., Dai, J. *, Ding, Y. * Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF
75. Cui, Y., Xiao, Z., Han, J., Sun, J., Ding, W., Zhao, Y., Chen, B., Li, X., and Dai, J.*. MiR-125b orchestrates cell proliferation, differentiation and migration in neural stem/progenitor cells by targeting Nestin
76. Gao, Y., Wei, J., Han, J., Wang, X., Su, G., Zhao, Y., Chen, B., Xiao, Z., Cao, J., Dai, J. *. The novel function of OCT4B isoform-265 in genotoxic stress
77. Chen, B., Xiao, Z., Shi, C. and Dai, J.*. Collagen-based Functional Biomaterials for Tissue Regeneration. Regenerative Medicine in China, S. Sanders Ed. A Sponsored supplement to Science
78. Lin, N., Li, X., Song, T., Wang, J., Meng, K., Yang, J., Hou, X., Dai, J.*, and Hu, Y. The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury
79. Li, L., Sun, J., Li, X., Zhang, Y., Wang, Z., Wang, C., Dai, J.*, and Wang, Q. Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity
80. Guan, J., Tong, W., Ding, W., Du, S., Xiao, Z., Han, Q., Zhu, Z., Bao, X., Shi. X., Wu, C., Cao, J., Yang, Y., Ma, W., Li, G., Yao, Y., Gao, J., Wei, J., Dai, J.*, and Wang, R. Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model
81. Chen, L., Xiao, Z., Meng, Y., Zhao, Y., Han, J., Su, G., Chen, B. and Dai, J.* The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs
82. Gao, J., Liu, J., Gao, Y., Wang, C., Zhao, Y., Chen, B., Xiao, Z., Miao, Q. and Dai, J.*. A Myocardial Patch Made of Collagen Membranes Loaded with Collagen-Binding Human Vascular Endothelial Growth Factor Accelerates Healing of the Injured Rabbit Heart
83. Li, X., Sun, H., Lin, N., Hou, X., Wang, J., Zhou, B., Xu, P., Xiao, Z., Chen, B., Dai, J. * and Hu, Y.* (2011) Regeneration of uterine horns in rats by collagen scaffolds loaded with collagen-binding human basic fibroblast growth factor
84. Han, Q., Li. B., Feng, H., Xiao, Z., Chen, B., Zhan, Y., Huang, J. and Dai, J.*. The promotion of cerebral ischemia recovery in rats by laminin-binding BDNF.Biomaterials
85. Cao, J., Sun, C.*, Zhao, H., Xiao, Z., Chen, B., Gao, J., Zheng, T., Wu, W., Wu, S., Wang, J., and Dai, J.*. The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats
86. Fan, J., Zhang, H., He, J., Xiao, Z., Chen, B., Jiang, X.*, Dai, J.* and Xu, R.*. Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transaction
87. Han, Q., Jin, W., Xiao, Z., Huang, J., Ni, H., Kong, J., Wu, J., Chen B., Liang, W., and Dai, J.*. The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor
88. Shi, C., Li, Q., Zhao, Y., Chen, W., Chen, B., Xiao, Z., Lin, H., Nie, L., Wang, D., and Dai, J.*. Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration
89. Shi, C., Chen, W., Zhao, Y., Chen, B., Xiao, Z., Wei, Z., Hou, X., Tang, J., Wang, Z., and Dai, J.*. Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor
90. He, Q., Zhao, Y., Chen, B., Xiao, Z., Zhang, J., Chen, L., Chen, W., Deng, F.* Dai, J.*. Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor
91. Zhang, J., Wang, X., Chen, B., Xiao, Z., Li, W., Lu, Y. and Dai, J.*. The human pluripotency gene NANOG/NANOGP8 is expressed in gastric cancer and associated with tumor development
92. Cao, J., Xiao, Z., Chen, B., Gao, Y., Shi, C., Wang, J., Dai, J.*. Differential effects of recombinant fusion proteins TAT-OCT4 and TAT-NANOG on adult human fibroblasts
93. Han, Q., Jin, W., Xiao, Z., Ni, H., Wang, J., Kong, J., Wu, J., Liang, W., Chen, L., Zhao, Y., Chen, B., and Dai, J.*. The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody
94. Liang, W.,Han, Q.,Jin, W., Xiao, Z., Huang, J., Ni, H., Chen, B., Kong, J., Wu,J.and Dai, J.*. The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF
95. Yan, X., Chen, B., Lin, Y., Li, Y., Xiao, Z., Hou, X., Tan, Q.* and Dai, J.*. Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model
96. Fan, J., Xiao, Z., Zhang, H., Chen, B., Tang, G., Hou, X., Ding, W., Wang, B., Zhang, P., Dai, J.* and Xu, R.*. Linear ordered collagen scaffolds loaded with collagen-binding neurotrophin-3 promotes axonal regeneration and partial functional recovery after complete spinal cord transaction
97. Dai, J. and Gao, S.. Stem cell research is coming of age in China
98. Gao, Y., Wang, X., Han, J., Xiao, Z., Chen, B., Su, G., Dai, J.*. The novel OCT4 spliced variant OCT4B1 can generate three protein isoforms by alternative splicing into OCT4B
99. Chen, W., Shi, C., Yi, S., Chen, B., Zhang, W., Fang, Z., Wei, Z., Jiang, S., Sun, X., Hou, X., Xiao, Z., Ye, G. and Dai, J.*. Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor
100. Wang, X. and Dai, J.*. Isoforms of OCT4 contribute to the confusing diversity in stem cell biology. Stem Cells
101. Zhang, W., Wang, X., Xiao, Z., Liu, W., Chen, B. and Dai, J.*. Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA
102. Ma, J., Meng, Y., Kwiatkowski, D.J., Chen, X., Peng, H., Sun, Q., Zha, X., Wang, F., Wang, Y., Jing, Y., Zhang, S., Chen, R., Wang, L., Wu, E., Cai, G., Malinowska-Kolodziej, I., Liao, Q., Liu, Y., Zhao, Y., Sun, Q., Xu, K., Dai, J., Han, J., Wu, L., Zhao, R.C., Shen, H
103. Chen, L., He, Z., Chen, B., Yang, M., Zhao, Y., Sun, W., Xiao, Z., Zhang, J. and Dai, J.*. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold
104. Gao, Y., Wang, B., Xiao, Z., Chen, B., Han, J., Wang, X., Zhang, J., Gao, S., Zhao, Y. and Dai, J.*. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells
105. Sun, W., Lin, H., Chen, B., Zhao, W., Zhao, Y., Xiao, Z. and Dai, J.*. Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing
106. Zhao, Y., Zhang, J., Wang, X., Chen, B., Xiao, Z., Shi, C., Wei, Z., Hou, X., Wang, Q. and Dai, J.*. The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies
107. Chen, L., He, Z., Chen, B., Zhao, Y., Sun, W., Xiao, Z., Zhang, J., Yang, M., Gao, Z. and Dai, J.*. Direct chemical cross-linking of platelet-derived growth factor-BB to the demineralized bone matrix improves cellularization and vascularization
108. Yang, Y., Zhao, Y., Chen, B., Han, Q., Sun, W., Xiao, Z. and Dai, J.*. Collagen-binding human epidermal growth factor promotes cellularization of collagen scaffolds
109. Sun, W., Sun, C., Zhao, H., Lin, H., Han, Q., Wang, J., Ma, H., Chen, B., Xiao, Z. and Dai, J.*. Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta
110. Wang, B., Gao, Y., Xiao, Z., Chen, B., Han, J., Zhang, J., Wang, X. and Dai, J.*. Erk1/2 promotes proliferation and inhibits neuronal differentiation of neural stem cells
111. Sun, W., Sun, C., Lin, H., Zhao, H., Wang, J., Ma, H., Chen, B., Xiao, Z. and Dai, J.*. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model
112. Ding, W., Lin, L., Ren, F., Zou, H., Duan, Z. and Dai, J.*. Effects of splice sites on the intron retention in histamine H3 receptors from rats and mice
113. Ding, W., Lin, L., Xiao, Z., Zou, H., Duan, Z. and Dai, J.*. Multiple sequence elements determine the intron retention in histamine H3 receptors in rats and mice
114. Gao, Y., Xiao, Z., Chen, B., Wang, B., Han, J., Zhao, Y., Zhang, J. and Dai, J.*. Effect of different regions of Nogo-A on the differentiation of neural progenitors
115. Han, Q., Sun, W., Lin, H., Zhao, W., Gao, Y., Zhao, Y., Chen, B., Xiao, Z., Hu, W., Li, Y., Yang, B. and Dai, J.* Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats
116. Wang, X., Zhao, Y., Xiao, Z., Chen, B., Wei, Z., Wang, B., Zhang, J., Han, J., Gao, Y., Li, L., Zhao, H., Zhao, W., Lin, H. and Dai, J.*. Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response.
117. Zhang, J., Ding, L., Zhao, Y., Sun, W., Chen, B., Lin, H., Wang, X., Zhang, L., Xu, B. and Dai, J.*. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction
118. Sun, B., Chen, B., Zhao, Y., Sun, W., Chen, K., Zhang, J., Wei, Z., Xiao, Z. and Dai, J.*. Crosslinking heparin to collagen scaffolds for the delivery of human platelet-derived growth facto
119. Zhao, W., Han, Q., Lin, H., Sun, W., Gao, Y., Zhao, Y., Wang, B., Wang, X., Chen, B., Xiao, Z. and Dai, J.*. Human basic fibroblast growth factor fused with kringle4 Peptide binds to a fibrin scaffold and enhances angiogenesis
120. Zhao, Y., Lin, H., Zhang, J., Chen, B., Sun, W., Wang, X., Zhao, W., Xiao, Z. and Dai, J.*. Crosslinked three-dimensional demineralized bone matrix for the adipose-derived stromal cell proliferation and differentiation
121. Zhao, Y., Chen, B., Lin, H., Sun, W., Zhao, W., Zhang, J. and Dai, J.*. The bone-derived collagen containing mineralized matrix for the loading of collagen-binding bone morphogenetic protein-2
122. Han, J., Wang, B., Xiao, Z., Gao, Y., Zhao, Y., Zhang, J., Chen, B., Wang, X. and Dai, J.* (2008) Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin
123. Zhao, W., Han, Q., Lin, H., Gao, Y., Sun, W., Zhao, Y., Wang, B., Chen, B., Xiao, Z. and Dai, J.*. Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin
124. Wang, B., Xiao, Z., Chen, B., Han, J., Gao, Y., Zhang, J., Zhao, W., Wang, X. and Dai, J.*. Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway
125. Zhang, J., Wang, B., Xiao, Z., Zhao, Y., Chen, B., Han, J., Gao, Y., Ding, W., Zhang, H. and Dai, J.*. Olfactory ensheathing cells promote proliferation and inhibit neuronal differentiation of neural progenitor cells through activation of Notch signaling
126. He, Z., Du, X., Yao, W. and Dai, J.*. Pharmaceutical proteins produced in plant bioreactor in recent years. African Journal of Biotechnology
127. Lin, H., Zhao, Y., Sun, W., Chen, B., Zhang, J., Zhao, W., Xiao, Z. and Dai, J.*. The effect of crosslinking heparin to demineralized bone matrix on mechanical strength and specific binding to human bone morphogenetic protein-2
128. Zhao, Y., Xiao, Z., Gao, Y., Chen, B., Zhao, Y., Zhang, J. and Dai, J.*. Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways
129. Sun, W., Lin, H., Chen, B., Zhao, W., Zhao, Y. and Dai, J.*. Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta
130. Zhao, Y., Wang, B., Gao, Y., Zhao, Y., Xiao, Z., Zhao, W., Chen, B., Wang, X. and Dai, J.*. Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation
131. Ma, S., Lin, H., Miao, Y., Liu, X., Wang, B. and Dai, J.*. The effect of three-dimensional demineralized bone matrix on in vitro cumulus-free oocyte maturation
132. Zhao, W., Chen, B., Li, X., Lin, H., Sun, W., Zhao, Y., Wang, B., Zhao, Y., Han, Q. and Dai, J.*. Vascularization and cellularization of collagen scaffolds incorporated with two different collagen-targeting human basic fibroblast growth factors
133. Chen, B., Lin, H., Wang, J., Zhao, Y., Wang, B., Zhao, W., Sun, W. and Dai, J.*. Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2
134. Chen, B., Lin, H., Zhao, Y., Wang, B., Zhao, Y., Liu, Y., Liu, Z. and Dai, J.*. Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide
135. Ding, W., Lin, L., Chen, B. and Dai, J.*. L1 elements, processed pseudogenes and retrogenes in mammalian genomes
136. Lin, H., Chen, B., Sun, W., Zhao, W., Zhao, Y. and Dai, J.*. The effect of collagen-targeting platelet-derived growth factor on cellularization and vascularization of collagen scaffolds
137. Suo, G., Chen, B., Zhang, J., Gao, Y., Wang, X., He, Z. and Dai, J.* Expression of active hBMP2 in transgenic tobacco plants
138. Lin, H., Chen, B., Wang, B., Zhao, Y., Sun, W. and Dai, J.*. Novel nerve guidance material prepared from bovine aponeurosis
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戴建武（右一）与子宫内膜再生临床研究宝宝互动 |
139. He, Z., Duan, Z., Liang, W., Chen, F., Yao, W., Liang, H., Yue, C., Sun, Z., Chen, F. and Dai, J.*. Mannose selection system used for cucumber transformation
140. Zhang, J., Wang, X., Li, M., Han, J., Chen, B., Wang, B. and Dai, J.*. NANOGP8 is a retrogene expressed in cancers
141. Zhang, J., Wang, X., Zhao, Y., Chen, B., Suo, G. and Dai, J.*. Neoplastic transformation of human diploid fibroblasts after long-term serum starvation
142. Wang, B., Zhao, Y., Lin, H., Chen, B., Zhang, J., Zhang, J., Wang, X., Zhao, W. and Dai, J.*. Phenotypical analysis of adult rat olfactory ensheathing cells on 3-D collagen scaffolds
143. Suo, G., Chen, B., Zhang, J., Duan, Z., He, Z., Yao, W., Yue, C. and Dai, J.*. Effects of codon modification on human BMP2 gene expression in tobacco plants
144. Gao, Y., Suo, G., Han, J., He, Z., Yao, W. and Dai, J.*. Expression of Human BM P-2 Gene in Different Tissues of Tobacco Plants
145. Ding, W., Zou, H., Dai, J.* and Duan, Z. Combining restriction digestion and touchdown PCR permits detection of trace isoforms of histamine H3 receptor
146. Zhang, J., Wang, X., Chen, B., Suo, G., Zhao, Y., Duan, Z. and Dai, J.*. Expression of Nanog gene promotes NIH3T3 cell proliferation
147. Suo, G., Han, J., Wang, X., Zhang, J., Zhao, Y., Zhao, Y. and Dai, J.*. Oct4 pseudogenes are transcribed in cancers
148. Dai J., et al. (2002) A novel signaling complex for stem cell differentiation
149. Dai J., and Michael P. Sheetz.. Membrane tether fromation from blebbing cells
150. Dai J., H. Ping Ting-Beall, Michael P. Sheetz, Robert M. Hochmuth, and Margaret A. Titus.. Myosin I contributes to the generation of resting cortical tension
151. Dai J., Michael. P. Sheetz, Xiaodong, Wan, and Catherine E. Morris.. Membrane tension in swelling and shrinking molluscan neurons
152. Dai J., H. Ping Ting-Beall and Michael P. Sheetz.. The secretion-coupled endocytosis correlates with membrane tension changes in RBL 2H3 cells
153. Dai J., and Michael P. Sheetz. Axon membrane flows from the growth cone to the cell body
154. Dai J., and Michael P. Sheetz. Mechanical Properties of Neuronal Growth Cone Membranes Studied by Tether Formation with Laser Optical Tweezers.
155. Dai J., Qun Dong, Yaxian Su, and Kechun Lin. Effect of ConA-receptor interaction on the structure of cell membranes
视频
戴建武：用再生医学，打造人的4S店
中国科学院教授戴建武，让高位截瘫患者四肢可以活动，创医学奇迹
参考来源
- ↑ 戴建武:做再生医学的“趟路人”,新华网
- ↑ 中国科学院遗传与发育生物学研究所 ,中国科学院, 2020-07-01
- ↑ 戴建武 ,活动家