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万向元
北京科技大学化学与生物工程学院

万向元,男,北京科技大学化学与生物工程学院教授。

人物简历

2016.12-至今:北京科技大学化学与生物工程学院,融合创新研究院,生物与农业研究中心,二级教授、博士生导师、党支部书记、中心主任;

2011.07-2016.11:主要农作物种质创新国家重点实验室,主任,教授级高级工程师,博士生导师;北京首佳利华科技有限公司,首席科学家;

2009.04-2011.06:国家作物分子设计工程技术研究中心,研究员;

2008.03-2009.02:美国康乃尔大学BTI植物研究所,博士后;

2005.12-2008.03:清华大学生物科学与技术系,博士后、助理研究员;

2000.09-2005.12:南京农业大学,博士,专业:作物遗传育种;

1996.09-2000.06:河南农业大学,学士,专业:农学。

科研方向

(1)玉米雄性不育机理解析与不育技术体系研究; (2)作物分子育种与应用研究; (3)植物生物技术与生物农业研究; (4)益生菌功能机理与应用研究。 社会职务:(1)中国作物学会常务理事; (2)中国生物工程学会理事常务理事、生物农业专委会副主任; (3)国家农业生物技术产业技术创新战略联盟副理事长/秘书长; (4)北京市专家联谊会理事、农业食品组副主任; (5)北京市平谷农业科技创新示范区专家委员会 委员; (6)国际学术期刊《ACS Agricultural Science & Technology》副主编; (7)《中国生物工程杂志》常务编委。

科研项目

主持国家自然科学基金项目、国家973计划课题、国家发改委生物育种专项、国家重点研发计划课题、国家科技部国际合作专项、北京市科技计划项目、北京市发改委生物育种平台专项等科研项目30余项,部分主持的项目如下:

(1)玉米核雄性发育基因Ms1/ZmLBD33调控花药细胞形成和花粉育性的分子机理研究,2018-2021,国家自然科学基金项目,56万元,项目负责人;

(2)主要农作物良种繁育关键技术研究与示范项目,2018-2021,国家重点研发计划,299万元,课题负责人;

(3)主要农作物种子分子指纹检测技术研究与应用,2017-2021,国家重点研发计划,100万元,任务负责人;

(4)新型辅助降“三高(血脂、血糖、血压)”功能益生菌的定向育种与功能性食品的开发,2018-2019,北京市科技专项,220万元,项目负责人;

(5)主要作物生物育种北京市工程实验室创新能力建设项目,2017-2019,北京市发改委生物育种平台专项,851万元,项目负责人; (6)国家“万人计划”中青年科技创新领军人才项目,2016-2018,中央组织部、国家科技部,90万元,项目负责人;

(7)玉米多控不育系的创制与产业化应用,2016-2018,北京市科技计划课题,290万元,项目负责人;

(8)北京市青年拔尖团队项目(作物育种与产业化应用创新团队),2016-2018,北京市委组织部/北京市科委,200万元,项目负责人;

(9)玉米多控不育技术体系的建立与杂交新品种的培育,2015-2017年,国家科技部国际科技合作专项,330万元,项目负责人

(10)玉米多控不育技术体系的建立与杂交新品种的培育,2013-2014,北京市科技计划课题,399.12万元,项目负责人;

(11)玉米高效育种技术体系研究与新品种产业化开发利用,2012-2013,国家发改委生物育种专项,600万元,项目负责人;

(12)玉米和专用枸杞高效育种体系的研究,2011-2013,国家973计划前期专项, 813万元,课题主持人。

获得奖励

(1)2016年,被中央组织部评为国家“万人计划”中青年科技创新领军人才;

(2)2021年,国家发明专利“一种基于Ms7基因构建的多控不育表达载体及其用于保持和繁殖玉米隐性核不育系的方法(ZL201510301333.2)”获第二十二届中国专利奖银奖,万向元为第一完成人;

(3)2020年,“玉米育种技术创新与品种推广应用”项目获中国产学研合作创新成果奖,二等奖,万向元为第一完成人;

(4)2020年,论文“ZmMs30 Encoding a Novel GDSL Lipase is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize”获第五届中国科协优秀科技论文奖,万向元为通讯作者;

(5)2019年,被评为“北京市有突出贡献的科学、技术、管理人才”;

(6) 2016年,获批“北京市青年拔尖团队”资质,即作物生物技术育种与产业化应用创新团队,万向元为团队带头人;

(7)2014年,被评为山东省泰山学者人才专家;

(8)2014年,被评为北京市海淀区海英高级人才专家;

(9)2013年,获批“国家创新人才推进计划重点领域创新团队资质”,即“主要农作物生物育种与产业化创新团队”,万向元为团队负责人;

(10)2013年,荣获“中关村国家级人才特区科技创新高端领军人才奖”,即“中关村高端领军人才奖”;

2. 获得国家发明专利(总计26项,代表性专利如下) 

(1)万向元,朱涛涛,安学丽等,雄性不育基因ZmMYB33及其在创制玉米雄性不育系中的应用,专利号:ZL 202110272228.6,授权公告号:CN 112680458 B;

(2)万向元、吴锁伟、张丹凤等,利用p5126-ZmMs1M构建体创制玉米显性核雄性不育系及其育种制种应用方法,专利号:ZL 201811449084.1,授权公告号:CN 109504701 B;

(3)万向元、张丹凤、吴锁伟等,利用p5126-ZmMs7M构建体创制玉米显性核雄性不育系及其育种制种应用方法,专利号:ZL 201811450364.4,授权公告号:CN 109504702 B;

(4)万向元、张丹凤、谢科等,利用p5126-ZmMs1D构建体创制玉米显性核雄性不育系及其育种制种应用方法,专利号:ZL 201811451837.2,授权公告号:CN 109504703 B;

(5)万向元、安学丽、吴锁伟等,利用Ubi-ZmMs1创制矮杆玉米自交系的方法与应用。国家发明专利,专利号:ZL 201910011868.4,授权公告号:CN 109679990 B;

(6)万向元、安学丽、谢科等,玉米隐性核雄性不育突变基因ms30的功能标记及其应用,专利号:ZL 201810867572.8,授权公告号:CN 108588273 B;

(7)万向元、孙倩、张勇等,一种具有调节血糖和胆固醇水平等益生功能的嗜酸乳杆菌La-SJLH001及其应用,专利号:ZL 201811177408.0,授权公告号:CN 109182207 B;

(8)万向元、张勇、孙倩等,一种具有减脂等功能的纳豆芽孢杆菌Bn-SJLH001益生作用及其应用,专利号:ZL 201811192859.1,授权公告号:CN 109251877 B;

(9)万向元,吴锁伟,周岩等,一种控制玉米雄性生育力的ZmMs7基因序列及其编码蛋白,专利号:ZL 201410338212.0,授权公告号:CN 105274118 B;

(10)万向元,吴锁伟,周岩等,植物花粉发育调控基因Ms1及其编码蛋白,专利号:ZL 201410381072.5,授权公告号:CN 105316344 B;

(11)万向元,吴锁伟,周岩等,一种玉米花粉减数分裂后发育调控基因Ms30的DNA序列及其编码蛋白,专利号:ZL 201410703778.9,授权公告号:CN 104946660 B;

(12)万向元,吴锁伟,谢科等,基于Ms1基因构建的介导玉米雄性生育力的多控不育载体及其应用,专利号:ZL 201510298173.0,授权公告号:CN 105018475 B;

(13)万向元,谢科,吴锁伟等,一种基于Ms30基因建立的玉米雄性不育系保持和繁殖的方法,专利号:ZL 201510300778.9,授权公告号:CN 105039316 B;

(14)万向元,谢科,吴锁伟等,一种基于Ms7基因构建的多控不育表达载体及其用于保持和繁殖玉米隐性核不育系的方法,专利号:ZL 201510301333.2,授权公告号:CN 105002206 B。

代表性论文论著

  已发表文章80多篇,总影响因子超过400,引用次数超过2800次;联合出版英文专著3部。
1、部分代表性SCI论文(*通讯作者,#同等贡献) 

(1)Xueli An#; Biao Ma #; Meijuan Duan#; Zhenying Dong#; Ruogu Liu; Dingyang Yuan; Quancan Hou; Suowei Wu; Danfeng Zhang; Dongcheng Liu; Dong Yu; Yuwen Zhang; Ke Xie; Taotao Zhu; Ziwen Li; Simiao Zhang; Youhui Tian; Chang Liu; Jinping Li; Longping Yuan*; Xiangyuan Wan*. Molecular regulation of ZmMs7 required for maize male fertility and development of a dominant male-sterility system in multiple species, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(38): 23499-23509.

(2)Xiangyuan Wan* ; Suowei Wu; Xiang Li; Breeding with Dominant Genic Male-Sterility Genes to Boost Crop Grain Yield in Post-Heterosis Utilization Era, Molecular Plant, 2021, 14(4): 531-534.

(3)Taotao Zhu#; Ziwen Li#; Xueli An#; Yan Long#; Xiaofeng Xue; Ke Xie; Biao Ma; Danfeng Zhang; Yijian Guan; Canfang Niu; Zhenying Dong; Quancan Hou; Lina Zhao; Suowei Wu; Jinping Li; Weiwei Jin; Xiangyuan Wan*. Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize , Molecular Plant, 2020, 13(11): 1624-1643 (封面文章).

(4)Xiangyuan Wan#*; Suowei Wu#; Ziwen Li; Xueli An; Youhui Tian; Lipid Metabolism: Critical Roles in Male Fertility and Other Aspects of Reproductive Development in Plants, Molecular Plant, 2020, 13(7): 955-983.

(5)Xueli An#; Zhenying Dong#; Youhui Tian#; Ke Xie#; Suowei Wu; Taotao Zhu; Danfeng Zhang; Yan Zhou; Canfang Niu; Biao Ma; Quancan Hou; Jianxi Bao; Simiao Zhang; Ziwen Li; Yanbo Wang; Tingwei Yan; Xiaojing Sun; Yuwen Zhang; Jinping Li; Xiangyuan Wan*. ZmMs30 Encoding a Novel GDSL Lipase is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize, Molecular Plant, 2019, 12(3): 343-359 (封面文章).

(6)Xiangyuan Wan#*; Suowei Wu#; Ziwen Li; Zhenying Dong; Xueli An; Biao Ma; Youhui Tian; Jinping Li; Maize Genic Male-sterility Genes and Their Applications in Hybrid Breeding: Progress and Perspectives, Molecular Plant, 2019, 12(3): 321-342. (7)Yilin Jiang#; Xueli An#; Ziwen Li#; Tingwei Yan#; Taotao Zhu; Ke Xie; Shuangshuang Liu; Quancan Hou; Lina Zhao; Suowei Wu; Xinze Liu; Shaowei Zhang; Wei He; Fan Li; Jinping Li; Xiangyuan Wan*. CRISPR/Cas9-based Discovery of Maize Transcription Factors Regulating Male Sterility and Their Functional Conservation in Plants, Plant Biotechnology Journal, 2021, doi: 10.1111/pbi.13590.

(8)Danfeng Zhang#; Suowei Wu#; Xueli An#; Ke Xie#; Zhenying Dong#; Yan Zhou; Liwen Xu; Wen Fang; Shensi Liu; Shuangshuang Liu; Taotao Zhu; Jinping Li; Liqun Rao; Jiuran Zhao*; Xiangyuan Wan*. Construction of a Multicontrol Sterility System for a Maize Male-sterile Line and Hybrid Seed Production basedon the ZmMs7 Gene Encoding a PHD-finger Transcription Factor, Plant Biotechnology Journal, 2018, 16(2): 459-471 (封面文章).

(9)Simiao Zhang#; Suowei Wu#; Canfang Niu#; Dongcheng Liu; Tingwei Yan; Youhui Tian; Shuangshuang Liu; Ke Xie; Ziwen Li; Yanbo Wang; Wei Zhao; Zhenying Dong; Taotao Zhu; Quancan Hou; Biao Ma; Xueli An; Jinping Li; Xiangyuan Wan*; ZmMs25 encoding a plastid-localized fatty acyl reductase is critical for anther and pollen development in maize, Journal of Experimental Botany, 2021, 72(12): 4298-4318.

(10)Taotao Zhu#; Suowei Wu#; Danfeng Zhang; Ziwen Li; Ke Xie; Xueli An; Biao Ma; Quancan Hou; Zhenying Dong; Youhui Tian; Jinping Li; Xiangyuan Wan*; Genome-wide analysis of maize GPAT gene family and cytological characterization and breeding application of ZmMs33/ZmGPAT6 gene, Theoretical and Applied Genetics, 2019, 132(7): 2137-2154.

(11)Ke Xie#; Suowei Wu# ; Ziwen Li# ; Yan Zhou; Danfeng Zhang; Zhenying Dong; Xueli An; Taotao Zhu; Simiao Zhang; Shuangshuang Liu; Jinping Li; Xiangyuan Wan*. Map-based cloning and characterization of Zea mays male sterility33 (ZmMs33) gene, encoding a glycerol-3-phosphate acyltransferase, Theoretical and Applied Genetics, 2018, 131(6): 1363-1378.

(12)Yuwen Zhang#; Ziwen Li#; Biao Ma; Quancan Hou; Xiangyuan Wan*. Phylogeny and Functions of LOB Domain Proteins in Plants, International Journal of Molecular Sciences, 2020, 21(7): 2278.

(13)Ziwen Li#; Xueli An#; Taotao Zhu; Tingwei Yan; Suowei Wu; Youhui Tian; Jinping Li; Xiangyuan Wan*; Discovering and Constructing ceRNA-miRNA-Target Gene Regulatory Networks during Anther Development in Maize , International Journal of Molecular Sciences, 2019, 20(14): 3480.

(14)Yanbo Wang#; Dongcheng Liu#; Youhui Tian#; Suowei Wu; Xueli An; Zhenying Dong; Simiao Zhang; Jianxi Bao; Ziwen Li; Jinping Li; Xiangyuan Wan*; Map-Based Cloning, Phylogenetic, and Microsynteny Analyses of ZmMs20 Gene Regulating Male Fertility in Maize , International Journal of Molecular Sciences, 2019, 20(6): 1411.

(15)Ziwen Li#; Taotao Zhu#; Shuangshuang Liu#; Yilin Jiang; Haoyun Liu; Yuwen Zhang; Ke Xie; Jinping Li; Xueli An*; Xiangyuan Wan*. Genome-wide Analyses on Transcription Factors and Their Potential microRNA Regulators involved in Maize Male Fertility, The Crop Journal, 2021, doi: https://doi.org/10.1016/j.cj.2021.03.016.

(16)Canfang Niu and Xiangyuan Wan*. Engineering a Trypsin-Resistant Thermophilic α-Galactosidase to Enhance Pepsin Resistance, Acidic Tolerance, Catalytic Performance, and Potential in the Food and Feed Industry. J Agric Food Chem. 2020, 68(39): 10560–10573.

(17)Qian Sun#, Yong Zhang#, Ziwen Li, Hai Yan, Jinping Li and Xiangyuan Wan*. Mechanism analysis of improved glucose homeostasis and cholesterol metabolism in high-fat-induced obese mice treated with La-SJLH001 via transcriptomics and culturomics. Food & Function, 2019, Jun 19;10(6):3556-3566.

(18)Yong Zhang#, Qian Sun#, Ziwen Li, Hongyuan Wang, Jinping Li, Xiangyuan Wan*. Fermented soybean powder containing Bacillus subtilis SJLH001 protects against obesity in mice by improving transport function and inhibiting angiogenesis. Journal of Functional Foods, 2019, 59, 60-70.

英文专著

(1)Xiangyuan Wan*; Suowei Wu*; Molecular Cloning of Genic Male-Sterility Genes and Their Applications for Plant Heterosis via Biotechnology-based Male-sterility Systems, Synthetic Biology-New Interdisciplinary Sciences, IntechOpen (DOI: http://dx.doi.org/10.5772/ intechopen.86976), 2020.

(2)Xiangyuan Wan* ; Ziwen Li* ; Plant Comparative Transcriptomics Reveals Functional Mechanisms and Gene Regulatory Networks Involved in Anther Development and Male Sterility, Transcriptome Analysis, IntechOpen, (DOI: http://dx.doi.org/10.5772/intechopen.88318), 2019.

(3)Xiangyuan Wan*; Ziwen Li*; Computational Identification of ceRNA and Reconstruction of ceRNA Regulatory Network Based on RNA-seq and Small RNA-seq Data in Plants. Methods in Molecular Biology, Vol. 2328, SHAHID MUKHTAR (Eds): Modeling Transcriptional Regulation, 978-1-0716-1533-1, 490717_1_En, 2021.[1]

参考资料