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萬向元檢視原始碼討論檢視歷史

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萬向元
北京科技大學化學與生物工程學院

萬向元,男,北京科技大學化學與生物工程學院教授。

人物簡歷

2016.12-至今:北京科技大學化學與生物工程學院,融合創新研究院,生物與農業研究中心,二級教授、博士生導師、黨支部書記、中心主任;

2011.07-2016.11:主要農作物種質創新國家重點實驗室,主任,教授級高級工程師,博士生導師;北京首佳利華科技有限公司,首席科學家;

2009.04-2011.06:國家作物分子設計工程技術研究中心,研究員;

2008.03-2009.02:美國康乃爾大學BTI植物研究所,博士後;

2005.12-2008.03:清華大學生物科學與技術系,博士後、助理研究員;

2000.09-2005.12:南京農業大學,博士,專業:作物遺傳育種;

1996.09-2000.06:河南農業大學,學士,專業:農學。

科研方向

(1)玉米雄性不育機理解析與不育技術體系研究; (2)作物分子育種與應用研究; (3)植物生物技術與生物農業研究; (4)益生菌功能機理與應用研究。 社會職務:(1)中國作物學會常務理事; (2)中國生物工程學會理事常務理事、生物農業專委會副主任; (3)國家農業生物技術產業技術創新戰略聯盟副理事長/秘書長; (4)北京市專家聯誼會理事、農業食品組副主任; (5)北京市平谷農業科技創新示範區專家委員會 委員; (6)國際學術期刊《ACS Agricultural Science & Technology》副主編; (7)《中國生物工程雜誌》常務編委。

科研項目

主持國家自然科學基金項目、國家973計劃課題、國家發改委生物育種專項、國家重點研發計劃課題、國家科技部國際合作專項、北京市科技計劃項目、北京市發改委生物育種平台專項等科研項目30餘項,部分主持的項目如下:

(1)玉米核雄性發育基因Ms1/ZmLBD33調控花葯細胞形成和花粉育性的分子機理研究,2018-2021,國家自然科學基金項目,56萬元,項目負責人;

(2)主要農作物良種繁育關鍵技術研究與示範項目,2018-2021,國家重點研發計劃,299萬元,課題負責人;

(3)主要農作物種子分子指紋檢測技術研究與應用,2017-2021,國家重點研發計劃,100萬元,任務負責人;

(4)新型輔助降「三高(血脂、血糖、血壓)」功能益生菌的定向育種與功能性食品的開發,2018-2019,北京市科技專項,220萬元,項目負責人;

(5)主要作物生物育種北京市工程實驗室創新能力建設項目,2017-2019,北京市發改委生物育種平台專項,851萬元,項目負責人; (6)國家「萬人計劃」中青年科技創新領軍人才項目,2016-2018,中央組織部、國家科技部,90萬元,項目負責人;

(7)玉米多控不育系的創製與產業化應用,2016-2018,北京市科技計劃課題,290萬元,項目負責人;

(8)北京市青年拔尖團隊項目(作物育種與產業化應用創新團隊),2016-2018,北京市委組織部/北京市科委,200萬元,項目負責人;

(9)玉米多控不育技術體系的建立與雜交新品種的培育,2015-2017年,國家科技部國際科技合作專項,330萬元,項目負責人

(10)玉米多控不育技術體系的建立與雜交新品種的培育,2013-2014,北京市科技計劃課題,399.12萬元,項目負責人;

(11)玉米高效育種技術體系研究與新品種產業化開發利用,2012-2013,國家發改委生物育種專項,600萬元,項目負責人;

(12)玉米和專用枸杞高效育種體系的研究,2011-2013,國家973計劃前期專項, 813萬元,課題主持人。

獲得獎勵

(1)2016年,被中央組織部評為國家「萬人計劃」中青年科技創新領軍人才;

(2)2021年,國家發明專利「一種基於Ms7基因構建的多控不育表達載體及其用於保持和繁殖玉米隱性核不育系的方法(ZL201510301333.2)」獲第二十二屆中國專利獎銀獎,萬向元為第一完成人;

(3)2020年,「玉米育種技術創新與品種推廣應用」項目獲中國產學研合作創新成果獎,二等獎,萬向元為第一完成人;

(4)2020年,論文「ZmMs30 Encoding a Novel GDSL Lipase is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize」獲第五屆中國科協優秀科技論文獎,萬向元為通訊作者;

(5)2019年,被評為「北京市有突出貢獻的科學、技術、管理人才」;

(6) 2016年,獲批「北京市青年拔尖團隊」資質,即作物生物技術育種與產業化應用創新團隊,萬向元為團隊帶頭人;

(7)2014年,被評為山東省泰山學者人才專家;

(8)2014年,被評為北京市海淀區海英高級人才專家;

(9)2013年,獲批「國家創新人才推進計劃重點領域創新團隊資質」,即「主要農作物生物育種與產業化創新團隊」,萬向元為團隊負責人;

(10)2013年,榮獲「中關村國家級人才特區科技創新高端領軍人才獎」,即「中關村高端領軍人才獎」;

2. 获得国家发明专利(总计26项,代表性专利如下) 

(1)萬向元,朱濤濤,安學麗等,雄性不育基因ZmMYB33及其在創製玉米雄性不育系中的應用,專利號:ZL 202110272228.6,授權公告號:CN 112680458 B;

(2)萬向元、吳鎖偉、張丹鳳等,利用p5126-ZmMs1M構建體創製玉米顯性核雄性不育系及其育種制種應用方法,專利號:ZL 201811449084.1,授權公告號:CN 109504701 B;

(3)萬向元、張丹鳳、吳鎖偉等,利用p5126-ZmMs7M構建體創製玉米顯性核雄性不育系及其育種制種應用方法,專利號:ZL 201811450364.4,授權公告號:CN 109504702 B;

(4)萬向元、張丹鳳、謝科等,利用p5126-ZmMs1D構建體創製玉米顯性核雄性不育系及其育種制種應用方法,專利號:ZL 201811451837.2,授權公告號:CN 109504703 B;

(5)萬向元、安學麗、吳鎖偉等,利用Ubi-ZmMs1創製矮杆玉米自交系的方法與應用。國家發明專利,專利號:ZL 201910011868.4,授權公告號:CN 109679990 B;

(6)萬向元、安學麗、謝科等,玉米隱性核雄性不育突變基因ms30的功能標記及其應用,專利號:ZL 201810867572.8,授權公告號:CN 108588273 B;

(7)萬向元、孫倩、張勇等,一種具有調節血糖和膽固醇水平等益生功能的嗜酸乳桿菌La-SJLH001及其應用,專利號:ZL 201811177408.0,授權公告號:CN 109182207 B;

(8)萬向元、張勇、孫倩等,一種具有減脂等功能的納豆芽孢桿菌Bn-SJLH001益生作用及其應用,專利號:ZL 201811192859.1,授權公告號:CN 109251877 B;

(9)萬向元,吳鎖偉,周岩等,一種控制玉米雄性生育力的ZmMs7基因序列及其編碼蛋白,專利號:ZL 201410338212.0,授權公告號:CN 105274118 B;

(10)萬向元,吳鎖偉,周岩等,植物花粉發育調控基因Ms1及其編碼蛋白,專利號:ZL 201410381072.5,授權公告號:CN 105316344 B;

(11)萬向元,吳鎖偉,周岩等,一種玉米花粉減數分裂後發育調控基因Ms30的DNA序列及其編碼蛋白,專利號:ZL 201410703778.9,授權公告號:CN 104946660 B;

(12)萬向元,吳鎖偉,謝科等,基於Ms1基因構建的介導玉米雄性生育力的多控不育載體及其應用,專利號:ZL 201510298173.0,授權公告號:CN 105018475 B;

(13)萬向元,謝科,吳鎖偉等,一種基於Ms30基因建立的玉米雄性不育系保持和繁殖的方法,專利號:ZL 201510300778.9,授權公告號:CN 105039316 B;

(14)萬向元,謝科,吳鎖偉等,一種基於Ms7基因構建的多控不育表達載體及其用於保持和繁殖玉米隱性核不育系的方法,專利號:ZL 201510301333.2,授權公告號:CN 105002206 B。

代表性論文論著

  已发表文章80多篇,总影响因子超过400,引用次数超过2800次;联合出版英文专著3部。
1、部分代表性SCI论文(*通讯作者,#同等贡献) 

(1)Xueli An#; Biao Ma #; Meijuan Duan#; Zhenying Dong#; Ruogu Liu; Dingyang Yuan; Quancan Hou; Suowei Wu; Danfeng Zhang; Dongcheng Liu; Dong Yu; Yuwen Zhang; Ke Xie; Taotao Zhu; Ziwen Li; Simiao Zhang; Youhui Tian; Chang Liu; Jinping Li; Longping Yuan*; Xiangyuan Wan*. Molecular regulation of ZmMs7 required for maize male fertility and development of a dominant male-sterility system in multiple species, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(38): 23499-23509.

(2)Xiangyuan Wan* ; Suowei Wu; Xiang Li; Breeding with Dominant Genic Male-Sterility Genes to Boost Crop Grain Yield in Post-Heterosis Utilization Era, Molecular Plant, 2021, 14(4): 531-534.

(3)Taotao Zhu#; Ziwen Li#; Xueli An#; Yan Long#; Xiaofeng Xue; Ke Xie; Biao Ma; Danfeng Zhang; Yijian Guan; Canfang Niu; Zhenying Dong; Quancan Hou; Lina Zhao; Suowei Wu; Jinping Li; Weiwei Jin; Xiangyuan Wan*. Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize , Molecular Plant, 2020, 13(11): 1624-1643 (封面文章).

(4)Xiangyuan Wan#*; Suowei Wu#; Ziwen Li; Xueli An; Youhui Tian; Lipid Metabolism: Critical Roles in Male Fertility and Other Aspects of Reproductive Development in Plants, Molecular Plant, 2020, 13(7): 955-983.

(5)Xueli An#; Zhenying Dong#; Youhui Tian#; Ke Xie#; Suowei Wu; Taotao Zhu; Danfeng Zhang; Yan Zhou; Canfang Niu; Biao Ma; Quancan Hou; Jianxi Bao; Simiao Zhang; Ziwen Li; Yanbo Wang; Tingwei Yan; Xiaojing Sun; Yuwen Zhang; Jinping Li; Xiangyuan Wan*. ZmMs30 Encoding a Novel GDSL Lipase is Essential for Male Fertility and Valuable for Hybrid Breeding in Maize, Molecular Plant, 2019, 12(3): 343-359 (封面文章).

(6)Xiangyuan Wan#*; Suowei Wu#; Ziwen Li; Zhenying Dong; Xueli An; Biao Ma; Youhui Tian; Jinping Li; Maize Genic Male-sterility Genes and Their Applications in Hybrid Breeding: Progress and Perspectives, Molecular Plant, 2019, 12(3): 321-342. (7)Yilin Jiang#; Xueli An#; Ziwen Li#; Tingwei Yan#; Taotao Zhu; Ke Xie; Shuangshuang Liu; Quancan Hou; Lina Zhao; Suowei Wu; Xinze Liu; Shaowei Zhang; Wei He; Fan Li; Jinping Li; Xiangyuan Wan*. CRISPR/Cas9-based Discovery of Maize Transcription Factors Regulating Male Sterility and Their Functional Conservation in Plants, Plant Biotechnology Journal, 2021, doi: 10.1111/pbi.13590.

(8)Danfeng Zhang#; Suowei Wu#; Xueli An#; Ke Xie#; Zhenying Dong#; Yan Zhou; Liwen Xu; Wen Fang; Shensi Liu; Shuangshuang Liu; Taotao Zhu; Jinping Li; Liqun Rao; Jiuran Zhao*; Xiangyuan Wan*. Construction of a Multicontrol Sterility System for a Maize Male-sterile Line and Hybrid Seed Production basedon the ZmMs7 Gene Encoding a PHD-finger Transcription Factor, Plant Biotechnology Journal, 2018, 16(2): 459-471 (封面文章).

(9)Simiao Zhang#; Suowei Wu#; Canfang Niu#; Dongcheng Liu; Tingwei Yan; Youhui Tian; Shuangshuang Liu; Ke Xie; Ziwen Li; Yanbo Wang; Wei Zhao; Zhenying Dong; Taotao Zhu; Quancan Hou; Biao Ma; Xueli An; Jinping Li; Xiangyuan Wan*; ZmMs25 encoding a plastid-localized fatty acyl reductase is critical for anther and pollen development in maize, Journal of Experimental Botany, 2021, 72(12): 4298-4318.

(10)Taotao Zhu#; Suowei Wu#; Danfeng Zhang; Ziwen Li; Ke Xie; Xueli An; Biao Ma; Quancan Hou; Zhenying Dong; Youhui Tian; Jinping Li; Xiangyuan Wan*; Genome-wide analysis of maize GPAT gene family and cytological characterization and breeding application of ZmMs33/ZmGPAT6 gene, Theoretical and Applied Genetics, 2019, 132(7): 2137-2154.

(11)Ke Xie#; Suowei Wu# ; Ziwen Li# ; Yan Zhou; Danfeng Zhang; Zhenying Dong; Xueli An; Taotao Zhu; Simiao Zhang; Shuangshuang Liu; Jinping Li; Xiangyuan Wan*. Map-based cloning and characterization of Zea mays male sterility33 (ZmMs33) gene, encoding a glycerol-3-phosphate acyltransferase, Theoretical and Applied Genetics, 2018, 131(6): 1363-1378.

(12)Yuwen Zhang#; Ziwen Li#; Biao Ma; Quancan Hou; Xiangyuan Wan*. Phylogeny and Functions of LOB Domain Proteins in Plants, International Journal of Molecular Sciences, 2020, 21(7): 2278.

(13)Ziwen Li#; Xueli An#; Taotao Zhu; Tingwei Yan; Suowei Wu; Youhui Tian; Jinping Li; Xiangyuan Wan*; Discovering and Constructing ceRNA-miRNA-Target Gene Regulatory Networks during Anther Development in Maize , International Journal of Molecular Sciences, 2019, 20(14): 3480.

(14)Yanbo Wang#; Dongcheng Liu#; Youhui Tian#; Suowei Wu; Xueli An; Zhenying Dong; Simiao Zhang; Jianxi Bao; Ziwen Li; Jinping Li; Xiangyuan Wan*; Map-Based Cloning, Phylogenetic, and Microsynteny Analyses of ZmMs20 Gene Regulating Male Fertility in Maize , International Journal of Molecular Sciences, 2019, 20(6): 1411.

(15)Ziwen Li#; Taotao Zhu#; Shuangshuang Liu#; Yilin Jiang; Haoyun Liu; Yuwen Zhang; Ke Xie; Jinping Li; Xueli An*; Xiangyuan Wan*. Genome-wide Analyses on Transcription Factors and Their Potential microRNA Regulators involved in Maize Male Fertility, The Crop Journal, 2021, doi: https://doi.org/10.1016/j.cj.2021.03.016.

(16)Canfang Niu and Xiangyuan Wan*. Engineering a Trypsin-Resistant Thermophilic α-Galactosidase to Enhance Pepsin Resistance, Acidic Tolerance, Catalytic Performance, and Potential in the Food and Feed Industry. J Agric Food Chem. 2020, 68(39): 10560–10573.

(17)Qian Sun#, Yong Zhang#, Ziwen Li, Hai Yan, Jinping Li and Xiangyuan Wan*. Mechanism analysis of improved glucose homeostasis and cholesterol metabolism in high-fat-induced obese mice treated with La-SJLH001 via transcriptomics and culturomics. Food & Function, 2019, Jun 19;10(6):3556-3566.

(18)Yong Zhang#, Qian Sun#, Ziwen Li, Hongyuan Wang, Jinping Li, Xiangyuan Wan*. Fermented soybean powder containing Bacillus subtilis SJLH001 protects against obesity in mice by improving transport function and inhibiting angiogenesis. Journal of Functional Foods, 2019, 59, 60-70.

英文專著

(1)Xiangyuan Wan*; Suowei Wu*; Molecular Cloning of Genic Male-Sterility Genes and Their Applications for Plant Heterosis via Biotechnology-based Male-sterility Systems, Synthetic Biology-New Interdisciplinary Sciences, IntechOpen (DOI: http://dx.doi.org/10.5772/ intechopen.86976), 2020.

(2)Xiangyuan Wan* ; Ziwen Li* ; Plant Comparative Transcriptomics Reveals Functional Mechanisms and Gene Regulatory Networks Involved in Anther Development and Male Sterility, Transcriptome Analysis, IntechOpen, (DOI: http://dx.doi.org/10.5772/intechopen.88318), 2019.

(3)Xiangyuan Wan*; Ziwen Li*; Computational Identification of ceRNA and Reconstruction of ceRNA Regulatory Network Based on RNA-seq and Small RNA-seq Data in Plants. Methods in Molecular Biology, Vol. 2328, SHAHID MUKHTAR (Eds): Modeling Transcriptional Regulation, 978-1-0716-1533-1, 490717_1_En, 2021.[1]

參考資料