劉見永檢視原始碼討論檢視歷史
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劉見永，男，福州大學化學學院教授。
人物簡歷
教育工作經歷
2011 - 2018 福州大學化學學院 副研究員、研究員
2008－2010 香港中文大學化學系 博士後
2005－2008 香港中文大學化學系 博士
研究方向
有機共軛大環化合物的合成及性能研究
研究興趣
氟硼二吡咯、酞菁類抗癌光敏藥物的設計與藥效研究；
有機染料分子熒光探針的設計及其在細胞、活體腫瘤中的成像研究；
染料敏化太陽能電池材料的設計及其光電轉換性能研究；
酞菁和氟硼二吡咯的超分子化學。
社會兼職
中國抗癌協會光動力治療專業委員會委員
中國化學會應用化學學科委員會卟啉與酞菁專業委員會秘書
受邀擔任Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Green Chemistry, Chemical Communications, Chemistry A European Journal, Organic Letters, RSC Advances, ChemMedChem, Current Medicinal Chemistry等期刊的通訊審稿人。
科研項目
1.國家自然科學基金：生物素介導靶向光動力治療-化療聯用抗癌藥物的合成及構效關係研究 (No.21401733)
2.國家自然科學基金：葉酸-酞菁共軛物抗癌光敏劑的合成及其靶向光動力活性 (No.21101028)
3.福建省科技廳重大項目：抗癌光敏劑福大賽因臨床 2期人體藥代動力學研究（No. 2015Y0086）
4. 福建省自然科學基金：光動力治療-化療聯用前藥的合成及協同抗腫瘤活性研究 （No. 2020J01440）
4.福建省自然科學基金：Cu（I）催化「點擊化學」合成靶向抗癌光敏劑 (No.2012J05021)
5.福州大學海外引進人才項目：功能配合物 (No.022382)
6.福州大學科研啟動項目：靶向抗癌光敏劑的研究 (No.600366)
7.福州大學科技發展基金：分子靶點抗癌光敏劑 (N0.2011-XY-6)
學術成果
論文
1. Xu, G.; Zhang, H.-X.; Li, X.-Q.; Yang, D.-C.; Liu, J.-Y.* 「Red light triggered photodynamic-chemo combination therapy using a prodrug caged by photosensitizer」, Eur. J. Med. Chem., 2021, 215, 113251. DOI: 10.1016/j.ejmech.2021.113251.
2. Weng, X.-L.; Liu, J.-Y.* 「Strategies for maximizing photothermal conversion efficiency based on organic dyes」, Drug Discov. Today, 2021. DOI: 10.1016/j.drudis.2021.03.009.
3. Song, M.; Liu, G.; Liu, Y.; Cheng, Z.; Lin, H.; Liu, J.-Y.; Wu, Z.; Xue, J.; Hong, W.; Huang, M.; Li, J.; Xu, P. 「Using porphyrins as albumin-binding molecules to enhance antitumorefficacies and reduce systemic toxicities of antimicrobial peptides」, Eur. J. Med. Chem., 2021, 217, 113382. DOI: 10.1016/j.ejmech.2021.113382.
4. Cao, J.-J.; Zhang, M.-S.; Li, X.-Q.; Yang, D.-C.; Xu, G.; Liu, J.-Y.* 「A glutathione-responsive photosensitizer with fluorescence resonance energy transfer characteristics for imaging-guided targeting photodynamic therapy」. Eur. J. Med. Chem., 2020, 193, 112203. DOI:10.1016/j.ejmech.2020.112203.
5. Dai, T.; Ye, F.-R; Hu, P.; Pan, X.; Su, J.; Huang, Y.; Chen, J.; Zhang, L.; Wang, H.; Huang, M.; Liu, J.-Y.; Chen, X.; Chen, Z.*, 「A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system」 Sci. China Mater., 2020, 64, 232-240.
6. Shi, W.-J.; Liu, J.-Y.; Lo, P.-C.; Ng, D. K.-P.*「Selective Detection of Hg2+ Ions with Boron Dipyrromethene-Based Fluorescent Probes Appended with a Bis(1,2,3-triazole)amino Receptor」, Chem. Asian.J., 2019, 14(7), 1059-1065.
7. Chen, Y.; Liu, J.; Song, M.; Jiang, L.; Liu, L; Liu, Y.; Fu, G.; Xue, J.; Liu, J.-Y.*; Huang, M.*; Li, J*. 「Insights into the binding mechanism of BODIPY-based photosensitizers to human serum albumin: A combined experimental and computational study」, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 203, 158–165.
8. Lin, H.; Chen, J.; Zhang, Y.; Ullab, A.; Liu, J.-Y.; Lin, F.; Jiang, L.; Huang, M*. 「Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine」, J. Inorg. Biochem., 2018, 189, 192–198.
9. Zhang, F.-L.; Song, M.-R.; Yuan, G.-K.; Ye, H.-N.; Tian, Y.; Huang, M.-D.; Xue, J.-P.; Zhang, Z.-H.*; Liu, J.-Y.* 「A Molecular Combo of Zinc(II) Phthalocyanine and Tamoxifen Derivative for Dual Targeting Photodynamic Therapy and Hormone Therapy」J. Med. Chem., 2017, 60, 6693-6703.
10. Liu, J.-Y.*; Hou, X.-N.; Tian, Y.; Jiang, L.*; Deng, S.; Röder, B.; Ermilov, E. A.* 「Photoinduced energy and charge transfer in a bis(triphenylamine)–BODIPY–C60 artificial photosynthetic system」, RSC Advances, 2016, 6, 57293-57305.
11. Liu, J.-Y.; Li, J.; Yuan, X.; Wang, W.-M.; Xue, J.-P.* 「In vitro photodynamic activities of zinc(II) phthalocyaninessubstituted with pyridine moieties」, Photodiagnosis and Photodynamic Therapy, 2016, 13, 341-343.
12. Chen, J.; Ye, H.; Zhang, M.; Li, J.; Liu, J.-Y.*; Xue, J.-P.* 「Erlotinib Analogue-substituted Zinc(II) Phthalocyanines for Small Molecular Target-based Photodynamic Cancer Therapy」, Chin. J. Chem., 2016, 34, 983-988.
13. Ermilov, E. A. *; Liu, J.-Y.; Menting, R.; Huang, Y.-S.; Röder, B.;Ng, D. K. P.*「An artificial photosynthetic model based on a molecular triad of boron dipyrromethene and phthalocyanine」Phys. Chem. Chem. Phys., 2016, 18, 10964-10975.
14. Zhang, F.-L.; Huang, Q.;Liu, J.-Y.; Huang, M.-D.; Xue, J.-P.* 「Molecular-Target-Based Anticancer Photosensitizer: Synthesis and in vitro Photodynamic Activity of Erlotinib–Zinc(II)Phthalocyanine Conjugates」 ChemMedChem, 2015, 10(2), 312-320.
15. Ermilov, E. A.*;Schlak, M.; Steffen, R.; Liu, X.-Q.; Liu, J.-Y.;Röder, B. 「Energy transfer properties of a novel boron dipyrromethene–perylenediimide donor–acceptor dyad」RSC Adv., 2015, 5, 67141-67148.
16. Zhou, X.-Q.; Meng, L.-B.; Huang, Q.; Li, J.; Zheng, K.; Zhang, F.-L.; Liu, J.-Y.; Xue, J.-P.* 「Synthesis and in vitro Anticancer Activity of Zinc(II) Phthalocyanines Conjugated with Coumarin Derivatives for Dual Photodynamic and Chemotherapy」 ChemMedChem, 2015, 10, 304-311.
17. Lin, J.; Zhu, C.; Liu, X.; Chen, B.; Zhang, Y.; Xue, J.;Liu, J.-Y.* 「A Highly Selective and turn-on fluorescence probe for Fe3+ ion based on perylene tetracarboxylic diimide」 Chin. J. Chem., 2014, 32, 1116-1120.
18. Jia, X.; Yue, F.; Chen, X.; Pan, H.-B.; Liu, W.-G.*; Liu, J.-Y.* 「One-pot controlled synthesis of single-crystal a-Fe2O3 hollow nanostructure and its gas sensing properties」RSC Adv., 2014, 4, 42899-42904.
19. Chen, Z.; Xu, P.; Chen, J.; Chen, H.; Hu, P.; Chen, X.; Lin, L.; Huang, Y.; Zheng, K.; Zhou, S.; Li, R.; Chen, S.; Liu, J.-Y.; Xue, J.; Huang, M. 「Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy」 Acta Biomaterialia, 2014, 10(10), 4257-4268.
20. Liu, J.-Y.; Huang, Y.-S.; Menting, R.; Röder, B.; Ermilov, E. A.;Ng, D. K. P.* 「A boron dipyrromethene-phthalocyanine pentad as an artificial photosynthetic model」 Chem. Commun.2013, 49, 2998-3000.
21. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* 「A light-harvesting porphyrin-boron dipyrromethene conjugate」J. Porphyrins Phthalocyanines2013, 17, 831-835.
22. Menting, R.;Liu, J.-Y.;Huang,Y.-S.;Ng, D. K. P.;Röder, B.;Ermilov, E. A.* 「Photoinduced energy and charge transfer in ap-phenylene-linked dyad of boron dipyrrometheneand monostyryl boron dipyrromethene」Phys. Chem. Chem. Phys.2013, 15, 6912-6919.
23. Zhang, F.-L.; Huang, Q.; Zheng, K.; Li, J.;Liu, J.-Y.*; Xue, J.-P.* 「A novel strategy for targeting photodynamic therapy.Molecular combo of photodynamic agent zinc(II)phthalocyanine and small molecule target-basedanticancer drug erlotinib」Chem. Commun.2013, 49, 9570-9572.
24. Jia, X.; Yang, F.-F.; Li, J.; Liu, J.-Y.; Xue, J.-P.*「Synthesis and in Vitro Photodynamic Activity of Oligomeric EthyleneGlycol−Quinoline Substituted Zinc(II) Phthalocyanine Derivatives」J. Med. Chem. 2013, 56, 5797-5805.
25. He, H.; Liu, J.-Y.;and Ng, D. K. P.* 「A Phthalocyanine-Based Fluorescent Sensor for Zn2+Ion」, J. Porphyrins Phthalocyanines」 2013, 17, 99-103.
26. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* 「Photoinduced Electron Transfer in a Ferrocene-Distyryl BODIPY Dyad and a Ferrocene-Distyryl BODIPY-C60 Triad」 ChemPhysChem, 2012, 13, 2030-2036.
27. Shi, W.-J.; Liu, J.-Y.; Ng, D. K. P.* 「A Highly Selective Colorimetric and Fluorescent Probe for Cu2+ and Hg2+ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3-triazole)amino Receptors」Chem. Asian.J.2012,7(1), 196-200.
28. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.*; Ng, D. K. P.* 「Mimicking the Photosynthetic Antenna-Reaction Center Complexes with a (Boron Dipyrromethene)3-Porphyrin-C60 Pentad」Chem. Eur.J.2011,17, 1605-1613.
29. Liu, J.-Y.; El-Khouly, M. E.; Fukuzumi, S.; Ng, D. K. P.* 「Photoinduced Electron Transfer in a Distyryl BODIPY-Fullerene Dyad」Chem. Asian.J.2011,6, 174-179.
30. Liu, J.-Y.; Lo, P.-C.; Ng, D. K. P.* 「Phthalocyanine-Containing Supramolecular Arrays」 Struct. Bond. 2010, 135, 169-210.
31. Liu, J.-Y.; Ermilov, E. A.; Röder, B.; Ng, D. K. P.* 「Switching the photo-induced energy and electron-transfer processes in BODIPY-phthalocyanine conjugates」 Chem. Commun.2009, 45, 1517-1519.
32. Liu, J.-Y.; Lo, P.-C.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* 「Synthesis and in vitrophotodynamic activities of di-a-substituted zinc(II) phthalocyanine derivatives」 Dalton Trans.2009, 38, 4129-4135.
33. Liu, J.-Y.; Lo, P.-C.; Fong, W.-P.; Ng, D. K. P.* 「Effects of the number and position of the substituents on the in vitro photodynamic activities of glucosylated zinc(II) phthalocyanines」 Org. Biomol. Chem.2009, 7, 1583-1591.
34. Ermilov, E. A.*; Liu, J.-Y.; Ng, D. K. P.*; Röder, B. 「Spectroscopic study of electron and energy transfer in novel silicon phthalocyanine-boron dipyrromethene triads」 Phys. Chem. Chem. Phys.2009, 11, 6430-6440.
35. Liu, J.-Y.; Yeung, H.-S.; Xu, W.; Li, X.; Ng, D. K. P.* 「Highly Efficient Energy Transfer in Subphthalocyanine-BODIPY Conjugates」 Org. Lett.2008, 10(23), 5421-5424.
36. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* 「Highly photocytotoxic 1,4-dipegylated zinc(II) phthalocyanines. Effects of the chain length on the in vitro photodynamic activities」 Org. Biomol. Chem.2008, 6, 4560-4566.
37. Liu, J.-Y.; Jiang, X.-J.; Fong, W.-P.; Ng, D. K. P.* 「Synthesis, Characterization, and in vitro Photodynamic Activities of Novel Amphiphilic Zinc(II) Phthalocyanines Bearing Oxyethylene-rich Substituents」 Metal Based Drugs 2008, Article ID: 284691.
38. Lo, P.-C.; Chan, C. M. H.; Liu, J.-Y.; Fong, W.-P.; Ng, D. K.-P.* 「Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties」 J. Med. Chem. 2007, 50(9), 2100-2107.[1]