劉鑒峰檢視原始碼討論檢視歷史
| 劉鑒峰 |
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劉鑒峰，男，研究員，博士生導師，國家優秀青年科學基金、天津市傑出青年基金獲得者，享受國務院特殊津貼 ； [1]
中國醫學科學院創新藥物放射性藥代重點實驗室主任，中國醫學科學院醫學與健康科技創新工程協同創新團隊項目首席專家，放射醫學研究所核醫學應用研究室主任。 [2]
兼任天津市藥理學會青年委員會主任委員，天津市醫學會核醫學分會常委，中國核學會同位素分會理事。 [3]
基本信息
人物說明----研究員，博士生導師，享受國務院特殊津貼
國 籍 ---- 中國
職 業 ---- 中國醫學科學院創新藥物放射性藥代重點實驗室主任
研究方向
納米醫學、影像醫學與核醫學。具體開展的研究內容:
1、納米藥物載體
2、多模態分子影像探針
3、藥物的放射性核素標記及臨床前藥代動力學研究
承擔項目
作為項目負責人承擔國家級省部級項目十餘項。
1、國家優秀青年科學基金項目:"納米醫用材料"(No. 81722026)，2018.1~2020.12項目負責人
2、天津市傑出青年科學基金項目:"體內自組裝多肽的構築及在腫瘤放療增敏中的應用研究"(No. 18JCJQJC47300)，2018.10~2022.9 項目負責人
3、中國醫學科學院"創新藥物放射性藥代研究重點實驗室"，2018.1~2020.12 實驗室主任
4、 中國醫學科學院醫學與健康科技創新工程協同創新團隊項目:"放射性核素標記藥物及臨床前藥代動力學關鍵技術研發"(No. 2016-12M-3-022)，2016.9~2020.12 首席專家
5、 天津市新藥創製科技重大專項:"低能放射性核素標記及藥物臨床前藥代動力學關鍵技術平台建設"，(No. 16ZXXYSY00040)，2016.10~2018.9 項目負責人
6、 科技部重大新藥創製科技重大專項:"天然產物來源創新藥物新品種研發及其關鍵創新技術體系"(No. 2018ZX09711001)，2018.1~2020.12 任務負責人
7、 國家自然科學基金面上項目:"智能化雙靶向腫瘤光學/核素/MRI多模態分子探針的合成及其性能研究"(No. 81471727)， 2015.1~2018.12 項目負責人
8、 國家自然科學基金面上項目:"顯像與放射免疫治療用PAMAM多功能納米材料的構建與性能研究"(No. 81171371)，2012.1~2015.12 項目負責人
9、 天津市自然科學基金重點項目:"新型腫瘤多模態納米分子探針的製備及其功能研究"(No. 13JCZDJC28100)，2013.4~2016.3 項目負責人
10、 國家自然科學基金青年項目:"新型納米抗腫瘤藥物靶向載體的製備及其功能研究"(No. 30700178), 2008.1~2010.12 項目負責人
發表文章
近年來發表SCI論文70餘篇，部分第一/通訊作者文章:
1. Yumin Zhang, Fan Huang, Chunhua Ren, Jinjian Liu, Lijun Yang, Shizhu Chen, Jinglin Chang, Cuihong Yang, Weiwei Wang, Chuangnian Zhang, Qiang Liu, Xing-Jie Liang,* Jianfeng Liu*. Enhanced Radiosensitization by Gold Nanoparticles with Acid-Triggered Aggregation in Cancer Radiotherapy. Advanced Science. Accepted.
2. Cuihong Yang, Xiang Ni, Duo Mao, Chunhua Ren, Jinjian Liu, Yang Gao, Dan Ding*, Jianfeng Liua*. Seeing the fate and mechanism of stem cells in treatment of ionizing radiation-induced injury using highly near-infrared emissive AIE dots.Biomaterials. 2018 Oct 11; 188: 107-117.
3. Lijun Yang, Congrou Zhang, Chunhua Ren, Jinjian Liu, Yumin Zhang, Jing Wang, Fan Huang*, Lei Zhang*, Jianfeng Liu*. Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy. ACS Applied Materials & Interfaces. 2018 Dec 18. doi: 10.1021/acsami.8b18425.
4. Yong Liu , Yijin Ren, Yuanfeng Li, Linzhu Su, Yumin Zhang, Fan Huang, Jinjian Liu, Jianfeng Liu*, Theo G. van Kooten, Yingli An, Linqi Shi*, Henny C. van der Mei*, Henk J. Busscher. Nanocarriers with conjugated antimicrobials to eradicate pathogenic biofilms evaluated in murine in vivo and human ex vivo infection models. Acta Biomaterialia. 2018 Aug 31; 79: 331-343.
5. Cuihong Yang, Chunhua Ren, Jie Zhou, Jinjian Liu, Yumin Zhang, Fan Huang, Dan Ding, Bing Xu*,Jianfeng Liu*. Dual Fluorescent- and Isotopic-Labelled Self-Assembling Vancomycin for in vivo Imaging of Bacterial Infections. Angewandte Chemie-International Edition. 2017 Feb 20;56(9):2356-2360
6. Yanbin Cai, Haosheng Shen, Jie Zhan, Mingliang Lin, Liuhan Dai, Chunhua Ren, Yang Shi, Jianfeng Liu*, Jie Gao*, Zhimou Yang*. Supramolecular "Trojan Horse" for nuclear delivery of dual anticancer drugs. Journal of the American Chemical Society. 2017 Feb 13;139(8):2876-2879. (ESI高被引論文)
7. Pingsheng Huang, Huijuan Song, Yumin Zhang, Jinjian Liu, Zhen Cheng, Xingjie Liang, Weiwei Wang*, Deling Kong, Jianfeng Liu*. FRET-enabled monitoring of the thermosensitive nanoscale assembly of polymeric micelles into macroscale hydrogel and sequential cognate micelles release. Biomaterials.2017 Jul 10;145:81-91.
8. Fan Huang,Yang Gao,Yumin Zhang,Tangjian Cheng,Hanlin Ou,Lijun Yang,Jinjian Liu*,Linqi Shi*,Jianfeng Liu*. Silver-Decorated Polymeric Micelles Combined with Curcumin for Enhanced Antibacterial Activity.ACS Applied Materials & Interfaces.2017 May 8; 9(20): 16880-16889
9. Liping Chu#, Honglin Gao#, Tangjian Cheng,Yumin Zhang, Jinjian Liu, Fan Huang, Cuihong Yang*, Linqi Shi*, Jianfeng Liu*. A charge-adaptive nanosystem for prolonged and enhanced in vivo antibiotics delivery. Chemical Communications. 2016 Apr 14; 52(37):6265-8.
10. Tangjian Cheng, Jinjian Liu, Jie Ren, Fan Huang, Hanlin Ou, Yuxun Ding, Yumin Zhang, Rujiang Ma, Yingli An, Jianfeng Liu*, Linqi Shi*. Green tea catechin-based complex micelles combined with doxorubicin to overcome cardiotoxicity and multidrug resistance. Theranostics.2016; 6(9): 1277-92.
11. Jinjian Liu, Qian Liu, Cuihong Yang, Yu Sun, Yumin Zhang, Pingsheng Huang, Junhui Zhou, Qiang Liu, Liping Chu, Fan Huang, Liandong Deng*, Anjie Dong, Jianfeng Liu*. cRGD-Modified Benzimidazole-based pH-Responsive Nanoparticles for Enhanced Tumor Targeted Doxorubicin Delivery. ACS Applied Materials & Interfaces. 2016 May 4:8(17):10726-36.
12. Yumin Zhang#, Cuihong Yang#, Weiwei Wang, Jinjian Liu, Qiang Liu, Fan Huang, Liping Chu, Honglin Gao, Chen Li, Deling Kong, Qian Liu*, Jianfeng Liu*. Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer. Scientific Reports. 2016 Feb 15; 6: 21225. (ESI高被引論文)
13. Jinjian Liu#, Hongzhang Deng#, Qiang Liu, Liping Chu, Yumin Zhang, Cuihong Yang, Xuefei Zhao, Pingsheng Huang, Liandong Deng, Anjie Dong*, Jianfeng Liu*. Integrin-targeted pH-responsive micelles for enhanced anticancer efficiency in vitro and in vivo. Nanoscale. 2015 Feb 13; 7(10): 4451-60.
14. Pingsheng Huang#, Yumin Zhang#, Weiwei Wang, Junhui Zhou, Yu Sun, Jinjian Liu, Deling Kong, Jianfeng Liu*, Anjie Dong*. Co-delivery of doxorubicin and 131I by thermosensitive micellar-hydrogel for enhanced in situ synergetic chemoradiotherapy.Journal of Controlled Release. 2015 Nov 10;220(Pt A): 456-64.
15. Cuihong Yang, Liping Chu, Yumin Zhang, Yang Shi, Jinjian Liu, Qiang Liu, Saijun Fan, Zhimou Yang, Dan Ding*, Deling Kong*, Jianfeng Liu*. Dynamic biostability, biodistribution, and toxicity of L/D-peptide-based supramolecular nanofibers. ACS Applied Materials & Interfaces. 2015 Feb 4; 7(4):2735-44.