李書鵬檢視原始碼討論檢視歷史
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李書鵬，男，北京大學深圳研究生院特聘研究員。
人物履歷
2016- 至今 北京大學深圳研究生院 特聘研究員
2012- 2016 助理教授 加拿大 多倫多大學 精神病學系
2010- 2016 研究科學家 (Research Scientist) 加拿大 多倫多大學 成癮與精神衛生研究中心
2005-2009 博士後 加拿大 多倫多大學 成癮性與精神衛生研究中心
2001年9月 —2005年2月 博士 神經生物學 自然科學學院 國立慶尚大學 晉州, 660-701, 韓國
1998年9月— 2001年7月 碩士 病理生理學 同濟醫學院 華中科技大學 武漢, 430030, 中國
1993年9月 — 1998年7月 學士 同濟醫科大學 武漢, 430030, 中國
獲獎情況
- 1999- 2000 華中科技大學研究生獎學金
- 2002-2005 Rotary 基金會留學生獎學金
- 2007-2008 CAMH 博士後研究獎學金
- 2008-2010 加拿大衛生部-TUSP研究獎學金
- 2008-2010 加拿大心臟病與中風基金會研究獎學金
- 2011 美洲華人生物學家協會「劉宗正教授「最佳論文獎
- 2011 Juliusz, Dorota and Zofia (Zosia) 神經精神藥理學紀念獎
研究興趣
各種神經遞質與受體系統間的協調作用是人腦發揮功能作用的基礎。但受體和下游信號系統的正常協調機制，受體功能異常導致神經和精神性疾病的機制尚不清楚。既往的研究表明，遞質與受體信號傳導和整合發生在不同的水平。在分子水平，受體以蛋白複合體的形式介導了學習記憶、缺血性中風、成癮、抑鬱症，和精神分裂症等；
在細胞水平，神經細胞不同部位的受體協同處理不同時稱的刺激，整合下游信號的激活和神經細胞興奮性，後者又進一步通過長時程或短時程的突觸變化改變了神經細胞間的通訊聯繫。受體對神經功能核團的調製最終體現為神經通路的改變，而神經通路最終介導了腦高級認知功能，如注意、記憶、情緒等。我們初步的研究以及大量早期的報道支持這樣一種假說，即發生在以上各水平的受體協調缺陷均可影響神經精神性疾病的發病，包括帕金森氏病和老年性痴呆。
藉助傳統的分子藥理學、電生理學、生物化學、成像、行為學方法，以及新近的化學生物學、基因學方法，我們的長期研究目標是發現、揭示發病相關的病理性受體和分子信號，為臨床診斷、藥物治療提供新的目標分子。
學術成果
1. Zhang H, Li T, Li S, Liu F. (2016) Cross-talk between α7 nAchR and NMDAR revealed by protein profiling. J Proteomics. 10;131:113-21.
2. Su P*, Li S*, Chen S, Lipina TV, Wang M, Lai TK, Lee FH, Zhang H, Zhai D, Ferguson SS, Nobrega JN, Wong AH, Roder JC, Fletcher PJ, Liu F. A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects. Neuron. 2014. pii: S0896-6273(14)01007-1. (* co-contributor)
3. Li S, Wong AH, Liu F. (2014) Ligand-gated ion channel interacting proteins and their role in neuroprotection. Front Cell Neurosci. 8:125.
4. Li S, Nai Q, Lipina TV, Roder JC, Liu F. (2013) α7nAchR/NMDAR coupling affects NMDAR function and object recognition. Mol Brain. 6(1):58.
5. Zhai D, Li S, Wang M, Chin K, Liu F. (2013) Disruption of the GluR2/GAPDH complex protects against ischemia-induced neuronal damage. Neurobiology of Disease 54:392-403.
6. Li S, Li Z, Pei L, Le AD, Liu F. (2012) α7 nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking. Journal of Experimental Medicine. 209:2141-7.
7. Wang M, Li S, Zhang H, Pei L, Zou S, Lee FJ, Wang YT, Liu F.(2012) Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity. Mol Brain. 5(1):13.
8. Lin Pei*, Shupeng Li*, Min Wang*, Mustansir Diwan, Hymie Anisman, Paul J. Fletcher, José N. Nobrega and Fang Liu. (2010) Uncoupling Dopamine D1-D2 Receptor Complex Exerts antidepressant-like Effects. Nature Medicine. 16:1393-5.(* co-contributor).
9. Qiang Nai*, Shupeng Li*, Szu-Han Wang*, Frank J.S. Lee，Paul W. Frankland and Fang Liu.(2010) Uncoupling the D1-NMDA receptor complex impairs NMDA-dependent LTP and working memory. Biologcial Psychiatry. 67:246-254.(* co-contributor).
10. Naha N, Li SP, Yang BC, Park TJ, Kim MO. (2009) Time-dependent exposure of nicotine and smoke modulate ultrasubcellular organelle localization of dopamine D1 and D2 receptors in the rat caudate-putamen. Synapse. 63:847-54.
11. Muhammad Imran Naseer, Li Shupeng, Myeong Ok Kim. (2009) Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain. Mol Brain. 2:20.
12. Zhang H, Li S, Wang M, Vukusic B, Pristupa ZB, Liu F. (2009) Regulation of dopamine transporter activity by carboxypeptidase E. Mol Brain. 2:10.
13. Jiang Y, Pei L, Li S, Wang M, Liu F.（2008）Extracellular dopamine induces the oxidative toxicity of SH-SY5Y cells. Synapse. 62:797-803.
14. Lee HY, Naha N, Li SP, Jo MJ, Naseer ML, Park MS, Park TJ, Chung BC, Kim MO. （2008）In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A. Synapse. 62:534-543.
15. Lee HY*, Li SP*, Park MS, Bahk YH, Chung BC, Kim MO. (2007) Ethanol's effect on intracellular signal pathways in prenatal rat cortical neurons is GABA(B1) dependent. Synapse. 61:622-628 (*co-contributor).
16. Park MS, Lee HY, Li SP, Koh PO, Bahk JY, Chung BC, Kim MO. (2007) Survival change of ventral mesencephalon-derived progenitor cells after grafting into unilateral intact adult rat striatum. J Vet Med Sci.69:25-30.
17. Li SP, Lee HY, Park MS, Bahk JY, Chung BC, Kim MO. (2006) Prenatal GABA(B1) and GABA(B2) receptors: Cellular and subcellular organelle localization in early fetal rat cortical neurons. Synapse. 60(8):557-66.
18. Li SP, Park MS, Jin GZ, Kim JH, Lee HL, Lee YL, Kim JH, Bahk JY, Park TJ, Koh PO, Chung BC, Kim MO (2005) Ethanol modulates GABA(B) receptor expression in cortex and hippocampus of the adult rat brain. Brain Res. 1061:27-35.
19. Li SP, Kim JH, Park MS, Bahk JY, Chung BC, Kim MO. (2005) Ethanol modulates the expression of GABA(B) receptor mRNAs in the prenatal rat brain in an age and area dependent manner. Neuroscie 134:857-66.
20. Li SP, Park MS, Kim JH, Kim MO (2004) Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. J Neurosci Res. 78:868-879.
21. Li SP, Deng YQ, Wang XC, Wang YP, Wang JZ (2004) Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity. J Pineal Res. 36:186-191.
22. Li S, Park MS, Kim MO (2004) Prenatal alteration and distribution of the GABA(B1) and GABA(B2) receptor subunit mRNAs during rat central nervous system development. Brain Res Dev Brain Res. 150:141-150.
23. Li S, Kim KY, Kim JH, Kim JH, Park MS, Bahk JY, Kim MO (2004) Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Neurosci Lett 363:29-32.
24. Li SP, Park MS, Yoon H, Rhee KH, Bahk JY, Lee JH, Park JS, Kim MO (2003) Differential distribution of GABA(B1) and GABA(B2) receptor mRNAs in the rat brain. Mol Cells. 16:40-47.
25. Kim MO, Li S, Park MS, Hornung JP (2003) Early fetal expression of GABA(B1) and GABA(B2) receptor mRNAs on the development of the rat central nervous system. Brain Res Dev Brain Res. 143:47-55.
26. Bahk JY*, Li S*, Park MS, Kim MO (2002) Dopamine D1 and D2 receptor mRNA up-regulation in the caudate-putamen and nucleus accumbens of rat brains by smoking. Prog Neuropsychopharmacol Biol Psychiatry. 26:1095-1104. (*co-first author).
27. Li SP, Park MS, Bahk JY, Kim MO (2002) Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. Neurosci Lett. 334:135-139. [1]