汪迎春檢視原始碼討論檢視歷史

汪迎春

來自網絡的圖片

汪迎春 博士， 中國科學院遺傳與發育生物學研究所研究員， 博士生導師。

研究方向1.運動細胞的蛋白質組學；2. 生物信息學及計算生物學；3.生物膜的功能蛋白質組學。

基本信息

人物說明----中國科學院遺傳與發育生物學研究所研究員， 博士生導師。

國 籍 ---- 中國

職 業 ---- 教育科研工作者

畢業院校----蘭州大學，中科院遺傳研究所

簡介

博士， 中國科學院遺傳與發育生物學研究所研究員， 博士生導師。

主要經歷

1994年獲蘭州大學生物系生態學及環境生物學學士;

1997年獲中科院遺傳研究所遺傳學碩士;

2003年獲Iowa State University遺傳學，生物信息及計算生物學雙專業博士學位(Co-major).

2003-2006年，為The Scripps Research Institute 免疫系博士後;

2006-2008年，為University of California, San Diego病理系及癌症研究中心博士後。

2008-2009年，為University of California, San Diego病理系Assistant Project Scientist.

2009年11月加入中國科學院遺傳與發育生物學研究所，入選中國科學院"百人計劃"。

研究方向

1.運動細胞的蛋白質組學

細胞在外界化學因子的誘導下會產生形態變化和定向運動(Chemotaxis or Directional cell migration). 這個反應對生物生長發育過程中的一些重要的生理及病理過程起着至關重要的作用.如癌細胞的轉移與擴散就是一種定向性細胞運動.我們將應用功能蛋白質組學研究運動細胞(包括癌細胞和神經細胞)在運動過程中的形態控制和信號轉導機制. 並找出控制細胞運動的關鍵性蛋白和關鍵性翻譯後修飾， 為與細胞運動相關的疾病的診斷和治療提供靶標。

2. 生物信息學及計算生物學

我們的生物信息及計算生物學研究主要是用來服務白質組學研究。我們將開發一些應用軟件來處理大規模的蛋白質組學數據和進行功能性預測. 同時我們建立一個關於蛋白質磷酸化位點的網絡數據庫 (a web-based relational database). 這個數據庫將包括磷酸化位點的功能和量化方面的信息.預計這個數據庫對於預測蛋白磷酸化信息與細胞的生物學表型之間的聯繫起到重要的作用。

3.生物膜的功能蛋白質組學

生物膜含有多種蛋白，包括各種受體，通道，以及具有催化活性的酶.膜蛋白對於生物的生長，發育，以及對外界環境變化的應答起着極其重要的作用.然而由於膜蛋白的不溶性，對它們的研究遠遠落後於對可溶性蛋白的研究.我們近期將利用光合藍藻的thylakoid membrane作為材料，進行膜蛋白的功能蛋白質組學和生物信息學研究. 未來我們還將開展動物細胞生物膜的功能蛋白質組學研究.

發表文章

Derous D, Mitchell SE, Green CL, Wang Y, Han JD, Chen L, Promislow DE, Lusseau1 D, Speakman JR, Douglas A. The effects of graded levels of calorie restriction: VII. Topological rearrangement of hypothalamic aging networks. Aging (Albany NY)

Chao Q, Gao ZF, Wang YF, Li Z, Huang XH, Wang YC, Mei YC, Zhao BG, Li L, Jiang YB, Wang BC. The proteome and phosphoproteome of maize pollen uncovers fertility candidate proteins

Mitchell SE, Delville C, Konstantopedos P, Derous D, Green CL, Wang Y, Han JJ, Promislow DE, Douglas A, Chen L, Lusseau D, Speakman JR. The effects of graded levels of calorie restriction: V. Impact of short term calorie and protein restriction on physical activity in the C57BL/6 mouse

Derous D, Mitchell SE, Green CL, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Speakman JR, Douglas A. The effects of graded levels of calorie restriction: VI. Impact of short-term graded calorie restriction on transcriptomic responses of the hypothalamic hunger and circadian signaling pathways

Wang Z, Li N, Shan J, Gonzalez N, Huang X, Wang Y, Inze D, and Li Y. SCFSAP controls organ size by targeting PPD proteins for degradation in Arabidopsis thaliana. Nature Communications

Wang T, Liang L, Xue Y, Jia PF, Chen W, Zhang MX, Wang YC, Li HJ, Yang WC. A receptor heteromer mediates the male perception of female attractants in plants

Zhang B, Wang X, Zhao Z, Wang R, Huang X, Zhu Y, Yuan L, Wang Y, Xu X, Burlingame AL, Gao Y, Sun Y, Tang W. OsBRI1 activates BR signaling by preventing binding between the TPR and kinase domains of OsBSK3 via phosphorylation

Wang J, Yu L, Huang X, Wang Y, Zhao J. Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics

Lusseau D, Mitchell SE, Barros C, Derous D, Green C, Chen L, Han JD, Wang Y, Promislow DE, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: IV. Non-linear change in behavioural phenotype of mice in response to short-term calorie restriction

Mitchell SE, Delville C, Konstantopedos P, Derous D, Green CL, Chen L, Han JD, Wang Y, Promislow DE, Douglas A, Lusseau D, Speakman JR. The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

Mitchell SE, Tang Z, Kerbois C, Delville C, Konstantopedos P, Bruel A, Derous D, Green C, Aspden RM, Goodyear SR, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

Mitchell SE, Delville C, Konstantopedos P, Hurst J, Derous D, Green C, Chen L, Han JJ, Wang Y, Promislow DE, Lusseau D, Douglas A, Speakman JR. The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

Ning DL, Liu KH, Liu CC, Liu JW, Qian CR, Yu Y, Wang YF, Wang YC*, Wang BC. Large-scale comparative phosphoprotein analysis of maize seedling leaves during greening

Bai C, Guo P, Zhao Q, Lv Z, Zhang S, Gao F, Gao L, Wang Y, Tian Z, Wang J, Yang F, Liu C. Protomer roles in Chloroplast Chaperonin Assembly and Function

Gao L, Wang J, Ge H, Fang L, Zhang Y, Huang X, Wang Y. Toward the complete proteome of Synechocystis sp

Hu J, Huang X, Chen L, Sun X, Lu C, Zhang L, Wang Y, Zuo J. Site-specific nitrosoproteomic identification of endogenously S-nitrosylated proteins in Arabidopsis

Gao L, Ge H, Huang X, Liu K, Zhang Y, Xu W, and Wang Y. Systematically Ranking the Tightness of Membrane Association for Peripheral Membrane Proteins

Yin P, Tu Z, Yin A, Zhao T, Yan S, Guo X, Chang R, Zhang L, Hong Y, Huang X, Zhou J, Wang Y, Li S, Li XJ. Aged Monkey Brains Reveal the Role of Ubiquitin-Conjugating Enzyme UBE2N in the Synaptosomal Accumulation of Mutant Huntingtin

Gao L, Huang X, Ge H, Zhang Y, Kang Y, Fang L, Liu K, Wang Y. Profiling and Compositional Analysis of the Exoproteome of Synechocystis sp

Liu K, Zhang J, Fu B, Xie H, Wang Y, Qian X. Evaluation of empirical rule of linearly correlated peptide selection (ERLPS) for proteotypic peptide-based quantitative proteomics

Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, Wang Y, Huang X. Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA

Li L, Li M, Yu L, Zhou Z, Liang X, Liu Z, Cai G, Gao L, Zhang X, Wang Y, Chen S, Zhou JM. The FLS2-associated kinase BIK1 directly phosphorylates the NADPH oxidase RbohD to control plant immunity

Gao L, Shen C, Liao L, Huang X, Liu K, Wang W, Guo L, Jin W，Huang F, Xu W, and Wang Y. Functional proteomic discovery of Slr0110 as a central regulator of carbohydrate metabolism in Synechocystis sp

Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y, Yang C. Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans

Zhai Q, Yan L, Tan D, Chen R, Sun J, Gao L, Dong MQ, Wang Y, Li C. Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity

Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL, KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer

Wang Y, and Klemke R. Proteomics method for identification of pseudopodium phosphotyrosine protein

Xu W, Wang Y*, Taylor E, Laujac A, Gao L, Savikhin S, Chitnis PR. Mutational analysis of photosystem I of Synechocystis sp. PCC 6803: the role of four conserved aromatic residues in the j-helix of PsaB

Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG 2nd, Smith RD, Klemke RL. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction

Wang Y, Yang F, Gritsenko MA, Wang Y, Clauss T, Liu T, Shen Y, Monroe ME, Lopez-Ferrer D, Reno T, Moore RJ, Klemke RL, Camp DG 2nd, Smith RD. Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells

Yang F, Waters KM, Miller JH, Gritsenko MA, Zhao R, Du X, Livesay EA, Purvine SO, Monroe ME, Wang Y, Camp DG 2nd, Smith RD, Stenoien DL. Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation

Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR 3rd, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression

Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK. Structures of PHR Domains from Mus musculus Phr1 (Mycbp2) Explain the Loss-of-Function Mutation (Gly1092 → Glu) of the C

Wang Y*, Xu W*, Chitnis PR. Identification and bioinformatic analysis of the thylakoid membrane proteome of Synechocystis sp

Ding SJ*, Wang Y*, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du X, Wang W, Moore RJ, Monroe ME, Purvine SO, Waters K, Heibeck TH, Adkins JN, Camp DG 2nd, Klemke RL, Smith RD. Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid induced chemotaxis using Dual-step 18O Labeling Coupled with Immobilized Metal Affinity Chromatography.

Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG 2nd, Smith RD, Klemke RL. Spatial Mapping of the Neurite and Soma Proteomes Reveals a Functional Cdc42/Rac Regulatory Network

Wang Y and Klemke RL. PhosphoBlast: A Computational Tool for Comparing Phosphoprotein Signatures among Large Datasets

Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL. Methods for Pseudopodia Purification and Proteomics Analysis

Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL. Profiling Signaling Polarity in Chemotactic Cells

Wang Y, and Klemke RL. Biochemical Purification of Pseudopodia from Migratory Cells

Wang Y, Hanley R and Klemke RL. Computational methods for comparison of large genomic and proteomic datasets reveals protein markers of metastatic cancer

Harvey D, Wang Y, Chitnis PR, Kothari SC. Computational Opportunities in Proteomics Research: Automation in data processing and analysis

Xu W, Tang H, Wang Y, Chitnis PR. Proteins of the cyanobacterial photosystem I

Hou JM, Boichenko VA, Wang YC, Chitnis PR, Mauzerall D. Thermodynamics of electron transfer in oxygenic photosynthetic reaction center: a photoacoustic study revealed a similarity to bacterial reaction centers on electron transfer in photosystem I in both volume change and entropy

Wang Y, Sun J, Chitnis PR. Proteomic study of the peripheral proteins from thylakoid membranes of the cyanobacterium Synechocystis sp