肖瑞平檢視原始碼討論檢視歷史
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肖瑞平，女，北京大學未來技術學院院長。
人物履歷
長期從事心血管及代謝疾病的基礎和轉化研究。在Nature、Nature Medicine、Nature Cell Biology、Molecular Cell、Circulation等雜誌發表論文160餘篇，引用超過11,000次。獲得2015年ISHR President Lecture Award。從2014年起，擔任《新英格蘭醫學雜誌》副主編。擔任美國心臟學會中大西洋地區指導委員會委員，國際心臟學會(ISHR)理事，以及美國臨床醫學研究會會士。
教育背景
1979-1984 同濟醫科大學 （學士學位）
1985-1987同濟醫科大學，生理學系 （碩士學位）
1987-1988 北京大學生物系，博士研究生
1991-1995 美國馬里蘭大學醫學院，生理學系，（博士學位）
工作簡歷
1988-1989 波多黎各大學醫學院，博士後
1990-1991 美國NIH心血管研究室，博士後
1992-1996 美國NIH/NIA心血管研究室, Staff Scientist
1996-2003 美國NIH/NIA心血管研究室, 研究員 （Unit Head）
2003-2010 美國NIH/NIA心血管研究室, 資深研究員（with tenure, Section Head）
所授課程
《分子醫學高級教程》（必修，3學分）
《生理學》（必修，3學分）
《心血管代謝病理生理》（選修，3學分）
《心血管藥理》（選修，3學分）
承擔項目
n 國家重點研發計劃 (子課題負責人，項目編號2018YFA0507603，「代謝疾病及其心血管併發症中蛋白質糖基化的功能研究」，本人負責317.8萬，2018.05-2023.12)
n 國家自然科學基金重大項目 (子課題負責人，項目編號81790621，「花生四烯酸代謝小分子在心肌重構進展中的變化規律及機制」，本人負責450萬，2018.01-2022.12)
n 國家自然科學基金重點項目 (課題負責人，項目編號81630008，「Beta-arrestin在心臟損傷和心衰中的作用及其機制研究「，263萬，2017.01-2021.12)
學術成果
論文
1. Peng Jiang#, Lejiao Ren L#, Li Zhi#, Zhong Yu, Fengxiang Lv, Fengli Xu, Wei Peng, Xiaoyu Bai, Kunlun Cheng, Li Quan, Xiuqin Zhang, Xianhua Wang, Yan Zhang, Dan Yang, Xinli Hu*, Rui-Ping Xiao*. Negative Regulation of AMPK Signaling by High Glucose via E3 Ubiquitin Ligase MG53. Molecular Cell, 2021, 81(3):629-637.
2. Dan Shan#, Sile Guo#, Hong-Kun Wu, Fengxiang Lv, Li Jin L, Mao Zhang, Peng Xie, Yimei Wang, Ying Song, Wu F, Lan F, Hu X, Cao CM*, Zhang Y*, Rui-Ping Xiao*. Cardiac Ischemic Preconditioning Promotes MG53 Secretion through H2O2-activated PKC-d Signaling. Circulation, 2020, 142(11):1077-1091.
3. Ying Song, Chanjuan Xu, Jianfeng Liu, Yulong Li, Huan Wang, Dan Shan, Irving W. Wainer, Xinli Hu, Yan Zhang*, Anthony Yiu-Ho Woo*, Rui-Ping Xiao. Heterodimerization with 5-HT2BR Is Indispensable for β2AR-mediated Cardioprotection. Circulation Research, 2020, 128(2):262-277.
4. Mao Zhang, Hua Gao, Dairu Liu, Xiaoming Zhong, Xiaolu Shi, Peng Yu, Li Jin, Yun Liu, Yajie Tang, Yunhu Song, Jinghao Liu, Xinli Hu, Chuan-Yun Li, Lei Song, Jun Qin, Fujian Wu, Feng Lan, Yan Zhang, Rui-Ping Xiao. CaMKII-d9 Promotes Cardiomyopathy through Disrupting UBE2T-dependent DNA Repair. Nature Cell Biology, 2019, 21:1152-1163.
5. Hong-Kun Wu #, Yan Zhang#, Chun-Mei Cao#, Xinli Hu, Meng Fang, YuanYao, Li Jin, Gengjia Chen, Peng Jiang, Shuo Zhang, Ruisheng Song, Wei Peng, Fenghua Liu, Jiaojiao Guo, Lifei Tang, Yanyun He, Dan Shan, Jin Huang, Zhou Zhou, Dao Wen Wang, Fengxiaong Lv*, Rui-Ping Xiao*. Glucose-sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis. Circulation, 2019, 139:901–914.
6. Yao Xiao#, Can Wang#, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li*, and Xiuqin Zhang*. Deficiency of PRKD2 Triggers Hyperinsulinemia and Metabolic Disorders. Nature Communication, 2018, 9(1): 2015.
7. Ting Zhang#, Yang Zhang #*, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen Zheng, Haibao Shang, Jun Zhang, Mao Zhang, Hongkun Wu, Jiaojiao Guo, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao*, Rui-Ping Xiao*. CaMKII Is A RIP3 Substrate Mediating Ischemia- and Oxidative Stress-Induced Myocardial Necroptosis. Nature Medicine, 2016, 22(2): 175-182.
8. Weizhong Zhu, Sharon Tsang, David M Browe, Anthony Yh Woo, Ying Huang, Chanjuan Xu, Jian-Feng Liu, Fengxiang Lv, Yan Zhang*, Rui-Ping Xiao*. Interaction of β1-Adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling. JCI Insight, 2016, 1(1): e84969.
9. Fenghua Liu#, Ruisheng Song#, Yuanqing Feng#, Jiaojiao Guo, Yanmin Chen, Yong Zhang, Tao Chen, Yanru Wang, Yanyi Huang, Chuan-Yun Li, Chunmei Cao, Yan Zhang, Xinli Hu*, Rui-Ping Xiao*. Upregulation of MG53 Induces Diabetic Cardiomyopathy through Transcriptional Activation of Peroxisome Proliferation-Activated Receptor α. Circulation, 2015, 131(9): 795-804.
10. Ruisheng Song, Wei Peng, Yan Zhang, Fengxiang Lv, Hong-Kun Wu, Jiaojiao Guo, Yongxing Cao, Yanbin Pi, Xin Zhang, Li Jin, Mao Zhang, Peng Jiang, Fenghua Liu, Shaoshuai Meng, Xiuqin Zhang, Ping Jiang, Chun-Mei Cao*, Rui-Ping Xiao*. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature, 2013, 494(7437): 375-379.[1]