袁彩檢視原始碼討論檢視歷史
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袁彩，男，福州大學生物科學與工程學院教授。
人物簡歷
2022.1- 福州大學生物科學與工程學院 研究員
2016.06－2021.12 福州大學生物科學與工程學院 副研究員
2011.01－2016.06 中國科學院福建物質結構研究所 副研究員
2010.06－2011.06 哈佛大學醫學院 訪問學者
2005.04－2010.12 中國科學院福建物質結構研究所 助理研究員
2005.03－2008.07 中國科學院福建物質結構研究所 生物化學與分子生物學 博士
2003.07－2005.04 中國科學院福建物質結構研究所 研究實習員
2000.09－2003.07 福建師範大學 生物化學與分子生物學 碩士
1995.08－2000.08 福建省福安市賽岐中學 中學老師
研究方向
科研項目
1.國家自然科學基金面上項目，內吞性膠原蛋白受體Endo180的結構研究（31570745），2016.01-2019.12
2.國家自然科學基金面上項目，肝細胞生長因子激活物抑制劑1的結構研究（31170707），2012.1-2015.12
3.國家自然科學基金面上項目，基質降解相關蛋白的結構研究（30770429），2008.1-2010.12
4.福建省自然科學基金（面上），基於結構的PDI抑制劑設計及其抗血栓活性研究，（2018J01897），2018.04-2021.04
5.福建省青年創新項目，基質胰酶及其抑制劑的結構研究（2009J05091），2009.1-2011.12
6.教育部留學回國人員科研啟動基金，肝細胞生長因子激活物抑制劑1的結構生物學及分子機理研究（教外司留2013693）2013-2015
學術成果
論文
1.Shujuan Yu, Yaqun Sui, Jiawei Wang, Yongdong Li, Hanlin Li, Longguang Jiang, Yingping Cao, Liqing Chen,Cai Yuan*, Mingdong Huang*. Crystal Structure and Cellular Functions of uPAR Dimer. Nature communications, 2022, 13:1665.
2.Chenghui Liang, Robert Flaumenhaft,Cai Yuan*, Mingdong Huang*. Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug Discovery Today, 2022, 27(2), 626-635. doi:10.1016/j.drudis.2021.10.018
3.Zhiwei Huang, Huajian Lin, Shujuan Yu, Hanlin Li, Yang Zhou, Yuan Cheng, Shanli Chen,Cai Yuan*, Mingdong Huang*. A versatile insertion point on albumin to accommodate peptides and maintain their activities. International journal of biological macromolecules, 2022, 205, 49-54. doi:10.1016/j.ijbiomac.2022.02.002
4.Shanli Chen, Dan Chen, Yurong Liu, Yanyan Xu, Huajian Lin, Yuan Cheng, Jinyu Li, Chun Meng, Mingli Liang,Cai Yuan*, Mingdong Huang*. Enhanced clot lysis by a single point mutation in a reteplase variant. British Journal of Haematology, 2022, 196(4), 1076-1085. doi:10.1111/bjh.17942
5.Di Zhang, Jingyi Chen, Qian Jing, Zheng Chen, Azeem Ullah, Longguang Jiang, Ke Zheng,Cai Yuan*, Mingdong Huang*. Development of a Potent Antimicrobial Peptide With Photodynamic Activity. Frontiers in Microbiology, 2021, 12. doi:10.3389/fmicb.2021.624465
6.Cai Yuan, Zhanzhi Guo, Shujuan Yu, Longguang Jiang*, Mingdong Huang*. Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discovery Today, 2021, 26(4), 1076-1085. doi:10.1016/j.drudis.2021.01.016
7.Shujuan Yu, Gaohui Sun, Yaqun Sui, Hanlin Li, Yuhan Mai, Guodong Wang, Ning Zhang, Yuhai Bi, George F. Gao, Peng Xu, Longguang Jiang,Cai Yuan*, Yang Yang*, Mingdong Huang*. Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds. Dyes and Pigments, 2021, 194. doi:10.1016/j.dyepig.2021.109570
8.Linlin Li, Mingxiang Huang, Jianshan Shen, Yao Wang, Rui Wang,Cai Yuan*, Longguang Jiang, Mingdong Huang. Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity. Journal of Infectious Diseases, 2021, 223(1), 178-179. doi:10.1093/infdis/jiaa642
9.Longguang Jiang,Cai Yuan*, Mingdong Huang*. A general strategy to inhibit serine protease by targeting its autolysis loop. Faseb Journal, 2021, 35(2). doi:10.1096/fj.202002139RR
10.Libin Jiang, Yunbin Jiang, Linlin Li, Ke Zheng, Shujuan Yu, Jinyu Li,Cai Yuan*, Mingdong Huang*. A supramolecular nanocarrier for efficient cancer imaging and therapy by targeting at matriptase. Journal of Controlled Release, 2021, 334, 153-163. doi:10.1016/j.jconrel.2021.04.019
11.Linlin Li, Dan Chen, Ke Zheng, Libin Jiang, Tao Dai, Ling Yang, Longguang Jiang, Zhuo Chen,Cai Yuan*, Mingdong Huang*. Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. Acs Applied Materials & Interfaces, 2020, 12(4), 4221-4230. doi:10.1021/acsami.9b18396
12.Yunbin Jiang, Lin Lin*, Shanli Chen, Longguang Jiang, Mette C. Kriegbaum, Henrik Grdsvoll, Line V. Hansen, Jinyu Li, Michael Ploug,Cai Yuan*, Mingdong Huang*. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain. International Journal of Biological Sciences, 2020, 16(6), 981-993. doi:10.7150/ijbs.39919
13.Libin Jiang, Yurong Liu, Xianyuan Xu, Dan Su, Huasong Zou, Jianyong Liu,Cai Yuan*, Mingdong Huang*. Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation. Frontiers in Microbiology, 2020, 11. doi:10.3389/fmicb.2020.571691
14.許燕艷,陳珊莉,陳丹,彭雙周,程媛,李金宇,李永坤,江龍光,袁彩*,黃明東*.缺血性腦卒中溶栓藥物研究進展.生物工程學報, 2020, 36(10), 2029-2039. doi:10.13345/j.cjb.200107
15.梁程輝,陳丹,廖馨源,江龍光,袁彩*,黃明東*.蛋白質二硫鍵異構酶的結構及抑制劑研究進展.生物化學與生物物理進展, 2020, 47(07), 595-606. doi:10.16476/j.pibb.2020.0065
16.Le Shang, Guangpu Xue, Lihu Gong, Yaxin Zhang, Shuangzhou Peng,Cai Yuan*, Mingdong Huang*. A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent. Analytica Chimica Acta, 2019, 1053, 98-104. doi:10.1016/j.aca.2018.12.005
17.Min Liu#, Lin Lin#, Gunilla Hoyer-Hansen, Michael Ploug, Hanlin Li, Longguang Jiang,Cai Yuan*, Jinyu Li*, Mingdong Huang*. Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Febs Letters, 2019, 593(11), 1236-1247. doi:10.1002/1873-3468.13397
18.Rui Li, Chenghui Liang, Longguang Jiang,Cai Yuan*, Mingdong Huang*. Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications, 2019, 510(4), 539-544. doi:10.1016/j.bbrc.2019.01.102
19.Dafeng Liu, Linsen Li, Jincan Chen, Zhuo Chen, Longguang Jiang,Cai Yuan*, Mingdong Huang*. Dissociation of zinc phthalocyanine aggregation on bacterial surface is key for photodynamic antimicrobial effect. Journal of Porphyrins and Phthalocyanines, 2018, 22(9-10), 925-934. doi:10.1142/s1088424618500888
20.Shijie Li, Linlin Li, Zhuo Chen, Guangpu Xue, Longguang Jiang, Ke Zheng, Jincan Chen, Rui Li,Cai Yuan*, Mingdong Huang*. A novel purification procedure for recombinant human serum albumin expressed in Pichia pastoris. Protein Expression and Purification, 2018, 149, 37-42. doi:10.1016/j.pep.2018.04.012
21.Min Liu,Cai Yuan*, Yunbin Jiang, Longguang Jiang, Mingdong Huang*. Recombinant hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2 cells, purification and crystallization. Acta Crystallographica Section F-Structural Biology Communications, 2017, 73, 45-50. doi:10.1107/s2053230x16020082
22.Min Liu,Cai Yuan*, Jan K. Jensen, Baoyu Zhao, Yunbin Jiang, Longguang Jiang, Mingdong Huang*. The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition. Journal of Biological Chemistry, 2017, 292(20), 8412-8423. doi:10.1074/jbc.M117.779256
23.郭團玉,趙寶玉,袁彩*,黃明東*.絲氨酸蛋白酶催化結構域無活性突變體的表達、純化與結晶].過程工程學報, 2017, 17(4), 834-838.
24.Shanli Chen#, Lin Lin#,Cai Yuan*, Henrik Gardsvoll, Mette C. Kriegbaum, Michael Ploug, Mingdong Huang*. Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor. Acta Crystallographica Section F-Structural Biology Communications, 2017, 73, 486-490. doi:10.1107/s2053230x17009748
25.Xiaolei Zhou, Mingming Xu, Hailong Huang, Andrew Mazar, Zafar Lqbal,Cai Yuan*, Mingdong Huang*. An ELISA method detecting the active form of suPAR. Talanta, 2016, 160, 205-210. doi:10.1016/j.talanta.2016.07.004
26.Cai Yuan, Henrik J. Jurgensen, Lars H. Engelholm, Rui Li, Min Liu, Longguang Jiang, Zhipu Luo, Niels Behrendt, Mingdong Huang*. Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding. Biochemical Journal, 2016, 473, 2359-2368. doi:10.1042/bcj20160276[1]