謝正偉檢視原始碼討論檢視歷史
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謝正偉，男，博士，北京大學國際癌症研究院、北京大學基礎醫學院副研究員、助理教授。主要應用交叉學科手段，包括人工智能和計算生物學方法，進行衰老和代謝疾病的機制研究和創新藥物研發。
科研成果
1）開發出第一代衰老微流芯片並發現衰老標記蛋白HSP104；2）發現端粒酶失活的初始時期細胞即呈現早衰現象及其保護機制；3）發明了代謝網絡中計算酶-流變化關係的的超立方收縮算法；4）發現小檗鹼可以延長野生小鼠的壽命並揭示其分子機制；5）發現抑制乙酰轉移酶Gcn5可以延長酵母和人細胞系的壽命；6）開發了基於深度學習和基因指紋的藥效預測系統——靈素系統等。以第一作者/通訊作者（含並列）在Nature Biotechnology、Cell、Aging Cell、Bioinformatics、JCIM等雜誌發表論文。
學術任職
中國藥理學會表觀遺傳分會委員，中國老年學和老年醫學學會抗衰老分會委員。
研究方向
實驗室綜合使用計算和實驗方法，包括人工智能，分子細胞實驗等，研究衰老和疾病的機制並進行創新藥物研發，具體方向包括：
1. 基於人工智能的藥物研發系統的開發
2. 衰老的分子機制和延長壽命的藥物的開發
3. 癌症、肥胖、非酒精性肝炎、幹細胞、痛風、骨質疏鬆等疾病方向的藥物研發
學術成果
論文
(1) Jie Zhu#, Jingxiang Wang#, Xin Wang#, Mingjing Gao#, Bingbing Guo#, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou,*, Ning Zhang*, Ruimao Zheng*, Zhengwei Xie* Prediction of Drug Efficacy from Transcriptional Profiles with Deep Learning Nature biotechnology 2021,39:1444-1452 doi: 10.1038/s41587-021-00946-z
(2) Jie Zhu，Weikaixin Kong，Zhengwei Xie*, Expression and Prognostic Characteristics of Ferroptosis-related Gene in Colon Cancer, Int. J. Mol. Sci. 2021, 22(11):5652. doi: 10.3390/ijms22115652.
(3) Yiming Wang#, Weikaixin Kong#, Liang Wang, Tianyu Zhang, Boyue Huang, Jia Meng, Baoxue Yang, Zhengwei Xie* and Hong Zhou* Multiple-purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis Int. J. Mol. Sci. 2020, 21(20), 7695;
(4) Weikaixin Kong#，Miaomiao Gao#, Yuchen Jin, Zhuo Huang*, Zhengwei Xie*, Prognostic model of patients with liver cancer based on tumor stem cell content and immune process, Aging , 2020 (12) 16, 16555-16578.
(5) Weikaixin Kong#, Xinyu Tu#, Weiran Huang, Yang Yang, Zhengwei Xie*, Zhuo Huang* Prediction and Optimization of NaV1.7 Sodium Channel Inhibitors Based on Machine Learning and Simulated Annealing, J. Chem. Inf. Model. May 18, 2020, 60（6）, 2739-2753 (doi:10.1021/acs.jcim.9b01180)
(6) Miaomiao Gao#, Weikaixin Kong#, Zhuo Huang*, Zhengwei Xie* Identification of Key Genes Related to Lung Squamous Cell Carcinoma Using Bioinformatics Analysis. Int. J. Mol. Sci. 2020, 21(8), 2994 (doi:10.3390/ijms21082994)
(7) Yao Dang#, Yongpan An#, Jinzhao He, Boyue Huang, Jie Zhu, Miaomiao Gao, Shun Zhang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell 2020; 19:e13060
(8) Boyue Huang#, Dandan Zhong#, Jie Zhu, Yongpan An, Miaomiao Gao, Shuai Zhu, Weiwei Dang, Xin Wang, Baoxue Yang* and Zhengwei Xie* Inhibition of Histone Acetyltransferase GCN5 Extends Lifespan in both Yeast and Human Cell Lines. Aging Cell 2020; 00:e13129
(9) Zhengwei Xie#*, Tianyu Zhang#, Qi Ouyang*, Genome-scale fluxes were predicted under the guidance of enzyme abundance using a novel Hyper-Cube Shrink Algorithm, Bioinformatics , 2018.2.1, 34(3): 502~510
(10) Zhengwei Xie#, Kyle Jay#, Dana L. Smith, Yi Zhang, Zairan Liu, Jiashun Zheng, Ruilin Tian, Hao Li*, and Elizabeth Blackburn*, Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length Cell , 2015, 160(5): 928-939
(11) Zhengwei Xie, Yi Zhang, Ke Zou, Onn Brandman, Chunxiong Luo, Qi Ouyang*, Hao Li*, Molecular Phenotyping of Aging in Single Yeast Cells Using a Novel Microfluidic Device, Aging Cell 2012, (11): 599~606[1]