邢國剛檢視原始碼討論檢視歷史
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邢國剛，男，北京大學基礎醫學院教授。
人物履歷
2001年於西安交通大學獲得博士學位，2003年於北京大學神經科學研究所博士後出站，留校任教。期間，2004年至2006年在美國Sanford Burnham Prebys (SBP)醫學研究所和威斯康星大學神經科學系做高級訪學。2003年至今於北京大學神經科學研究所歷任講師(2003年)、副教授(2004年)、教授(2013年)。
社會兼職
中國神經科學學會神經內穩態與內分泌分會常務委員，中國神經科學學會感覺和運動分會、中華醫學會疼痛學分會、中國針灸學會針刺麻醉分會、中華醫學會兒科學分會腦科學委員會、中國微循環學會神經變性病專業委員會等專業委員會委員。Journal of Pain Research、Frontiers in Pain Research、Annals of Biomedical Research、World Journal of Anesthesiology、World Journal of Psychiatry、中國疼痛醫學雜誌等學術期刊編委。國家自然科學基金、北京市自然科學基金等評審專家。
研究方向
(1) 疼痛與記憶、認知和情緒機制研究：採用分子生物學、細胞生物學、行為藥理學、基因組學、代謝組學和單細胞測序的方法，結合神經示蹤、活體鈣成像、電生理學、光遺傳學、化學遺傳學和表觀遺傳學技術，從分子、細胞水平，突觸水平，以及神經網絡水平來研究離子通道與慢性痛的感覺、認知和負性情緒機制，包括疼痛記憶、認知障礙、焦慮、抑鬱及其共病的中樞神經網絡機制。
(2) 幹細胞與神經發育障礙性疾病研究：採用細胞重編程技術，利用化學小分子誘導人尿源性和血源性iPS細胞，定向分化神經細胞、體外培養腦類器官，建立神經發育障礙性疾病的細胞模型及腦類器官模型；結合上述各種神經生物學技術和組學方法，研究神經發育障礙性疾病的發病機制；結合基因編輯技術進行疾病的干預措施研究。
(3) 男性生殖細胞發育障礙及不孕不育機制研究：採用分子生物學、細胞生物學、基因組學、代謝組學和單細胞測序的方法，結合電生理學、表觀遺傳學和細胞重編程技術，研究男性生殖細胞發育障礙及不孕不育機制。
科研基金
(1) 國家自然科學基金面上項目，82171226，神經病理痛共病抑鬱症的杏仁核內部微環路及分子機制研究，2022/01-2025/12，55萬元，主持。
(2) 北京市自然科學基金面上項目，7222105，杏仁核調控神經病理痛共病抑鬱症的內部微環路及分子機制，2022/01-2024/12，20萬元，主持。
(3) 國家自然科學基金面上項目，81974169，杏仁核在慢性應激加重神經病理痛中的作用及神經調控環路機制研究，2020/01-2023/12，55萬元，主持。
(4) 國家重點研發計劃項目，2019YFC1712104，循經配穴治療坐骨神經痛的軀體感覺傳入機制研究，2019/12-2021/06，127萬元（總經費757萬元），主持（課題負責人）。
(5) 國家自然科學基金面上項目，81671085，P2X3嘌呤能受體的轉錄調控及其在大鼠骨癌痛中的作用研究，2017/01-2020/12，60萬元，主持。
(6) 國家自然科學基金(國家重大科研儀器研製項目)，61527815，多層次調控與高通量神經信號同步檢測儀器，2016/01-2020/12，148萬元（總經費625萬元），參加（合作單位負責人）。
(7) 國家自然科學基金面上項目，81371237，KCNQ/M(Kv7)鉀通道的轉錄抑制調控及其在大鼠骨癌痛中的作用研究，2014/01-2017/12，70萬元，主持。
(8) 國家重點基礎研究發展計劃(973計劃)課題，2013CB531905，針藥複合麻醉鎮痛機制研究，2013/01-2017/12，125萬元（總經費625萬元），參加（子課題負責人）。
(9) 國家衛生健康委員會行業專項基金，201302013-01，經皮穴位電刺激技術在生殖醫學中的應用研究，2013/01-2017/12，100萬元（總經費603萬元），參加（子課題負責人）。
(10) 國家自然科學基金面上項目，31171063，KCNQ/M電壓門控鉀通道在骨癌痛中的作用及機制研究，2012/01-2015/12，68萬元，主持。
(11) 國家自然科學基金預探索項目，81072951，生精散激活精子特異性鈣通道蛋白CatSper治療弱精子症的臨床與基礎研究，2011/01-2011/12，10萬元，，主持。
(12) 國家自然科學基金(儀器專項)，61027001，高通量神經信息檢測分析儀器研製，2011/01-2013/12，45萬元（總經費180萬元），參加（合作單位負責人）。
(13) 北京市自然科學基金面上項目，7112079，BDNF激活NMDA受體2B亞基磷酸化在神經病理痛中的作用，2011/01-2013/12，11萬元，，主持。
(14) 國家重點基礎研究發展計劃(973計劃)課題，2009CB522003，阿片類物質精神依賴的神經生物學機制，2009/01-2013/12，30萬元（總經費600萬元），參加（主要骨幹）。
(15) 教育部留學回國人員科研啟動基金，2008890，背根神經節神經元超極化激活電流(Ih)參與大鼠神經病理痛的分子機制，2008/06-2011/06，2萬元，主持。
(16) 國家重點基礎研究發展計劃(973計劃)課題，2007CB512501，針麻鎮痛中高級中樞痛覺信息調製迴路的作用，2007/07-2011/08，145萬元（總經費682.7萬元），參加（子課題負責人）。
(17) 國家自然科學基金面上項目，30370470，脊髓背角突觸傳遞的長時程抑制在電針治療神經病理痛中的作用及其機理研究，2004/01-2006/12，20萬元，主持。
獲獎情況
(1) 2019年北京市科學技術獎(自然科學獎)二等獎(新型生物信息微納傳感器應用基礎研究，證書號: 2019-Z02-2-01-R04)
(2) 2012年度北京市科學技術獎二等獎(針刺治療慢性痛的神經生物學機制研究，證書號: 2012醫-2-002-03)
(3) 2010年中國針灸學會科學技術獎二等獎 (中醫針灸學理論指導下針刺鎮痛的神經生物學機制研究) (證書號: ZJ2010003-2-03)
學術成果
論文
(1) Hong Yao, Minghui Liu, Leibo Wang, Yumeng Zu, Chou Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi, Shuangquan Chen, Xuanyu Gu, Tianya Liu, Jie Cai, Shirong Wang, Maojun Yang, Guo-Gang Xing, Wei Xiong, Lan Hua, Yefeng Tang and Gelin Wang. Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Research 2022 April 22; 0:1–15.
(2) Yajie Liu, YuAn, Guo-Gang Xing, Zirun Jin, KeXi, Yongwei Huo, Rui He, Hao Wang, Xiali Ouyang, Yueping Huang, Chang Huang, Li Han, Baixiao Zhao. Effect of moxa smoke on sperm parameters and oxidative stress in rats with asthenozoospermia. Anatomical Record (Hoboken) 2022 Jun 6. doi: 10.1002/ar.25002.
(3) Wang Wang, Wei-Zhen Liu, Zi-Liang Wang, Dong-Xiao Duan, Xue-Yun Wang, Shi-Jin Liu, Zhi-Ju Wang, Guo-Gang Xing*, Ying Xing*. Spinal microglial activation promotes perioperative social defeat stress-induced prolonged postoperative pain in a sex-dependent manner. Brain, Behavior, and Immunity 2022 Feb;100:88-104.
(4) Min Hao, Zixian Zhang, Chao Liu, Yue Tian, Jiazhi Duan, Jianlong He, Zhaoyang Sun, He Xia, Shan Zhang, Shuhua Wang, Yuanhua Sang*, Guo-Gang Xing*, Hong Liu*. Hydroxyapatite Nanorods Function as Safe and Effective Growth Factors Regulating Neural Differentiation and Neuron Development. Advanced Materials 2021 Aug;33(33):e2100895.
(5) Hong Jiang#, Jiang-Ping Liu#, Ke Xi#, Ling-Yu Liu, Ling-Yu Kong, Jie Cai, Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-Gang Xing*. Contribution of AMPA receptor-mediated LTD in LA/BLA-CeA pathway to comorbid aversive and depressive symptoms in neuropathic pain. Journal of Neuroscience 2021 Aug 25;41(34):7278-7299.
(6) Jiang-Ping Liu#, Hong-Bo Jing#, Ke Xi, Zi-Xian Zhang, Zi-Run Jin, Si-Qing Cai, Yue Tian, Jie Cai and Guo-Gang Xing*. Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats. Molecular Pain 2021 Jun; 17:17448069211023230.
(7) Zi-Run Jin, Dong Fang, Bo-Heng Liu, Jie Cai, Wen-Hao Tang, Hui Jiang, Guo-Gang Xing*. Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia. Theranostics 2021 Jan 1;11(6):2822-2844.
(8) Xiao-Yu Chen, Dan-Yu Song, Li Jiang, Dan-Dan Tan, Yi-Dan Liu, Jie-Yu Liu, Xing-Zhi Chang, Guo-Gang Xing, Tatsushi Toda, Hui Xiong*. Phenotype and genotype study of chinese POMT2-related a-dystroglycanopathy. Frontiers in Genetics 2021 Aug 3;12:692479.
(9) Shiyang Huang#, Can Zheng#, Guoguang Xie#, Zhanming Song, Pingzhang Wang, Yun Bai, Dixin Chen, Yan Zhang, Ping Lv, Weiwei Liang, Shaoping She, Qingqing Li, Zhongtian Liu, Yun Wang, Guo-Gang Xing*, Ying Wang*. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Molecular Psychiatry 2021 Jun;26(6): 2363-2379.
(10) Ran Huo#, Song-Ping Han#, Feng-Yu Liu, Xiao-Jing Shou, Ling-Yu Liu, Tian-Jia Song, Fu-Jun Zhai, Rong Zhang, Guo-Gang Xing*, Ji-Sheng Han*. Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats. Neuroscience Bulletin 2020 Aug;36(8):907-918.
(11) Meng Xue, Ya-Lan Sun, Yang-Yang Xia, Zhi-Hua Huang, Cheng Huang* and Guo-Gang Xing*. Electroacupuncture modulates spinal BDNF/TrkB signaling pathway and ameliorates the sensitization of dorsal horn WDR neurons in spared nerve injury rats. International Journal of Molecular Sciences 2020 Sep 7;21(18): E6524.
(12) Ya-Jing Liang, Shi-Yang Feng, Ya-Ping Qi, Kai Li, Zi-Run Jin, Hong-Bo Jing, Ling-Yu Liu, Jie Cai, Guo-Gang Xing*, Kai-Yuan Fu*. Contribution of microglial reaction to increased nociceptive responses in high-fat-diet (HFD)-induced obesity in male mice. Brain, Behavior, and Immunity 2019 Aug; 80:777-792.
(13) Yu Zhang, Shengwei Xu, Guihua Xiao, Yilin Song, Fei Gao, Mixia Wang, Hongyan Zhao, Guogang Xing, Xinxia Cai*. High frequency stimulation of subthalamic nucleus synchronously modulates primary motor cortex and caudate putamen based on dopamine concentration and electrophysiology activities using microelectrode arrays in Parkinson's disease rats. SENSORS AND ACTUATORS B-CHEMICAL 2019 Dec 12; 301:127126.
(14) Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Hongyan Zhao, Jingyu Xie, Shengwei Xu, Fei Gao, Mixia Wang, Guogang Xing, Xinxia Cai*. Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson's Disease. ACS Sensors 2019 Aug 23;4(8):1992-2000.
(15) Ling-Yu Liu, Rui-Ling Zhang, Lin Chen, Hong-Yan Zhao, Jie Cai, Jia-Kang Wang, Da-Qing Guo, Yan-Jun Cui*, Guo-Gang Xing*. Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats. Experimental Neurology 2019 Mar;313:109-123.
(16) Yue Yang#, Song Li#, Zi-Run Jin#, Hong-Bo Jing#, Hong-Yan Zhao, Bo-Heng Liu, Ya-Jing Liang, Ling-Yu Liu, Jie Cai, You Wan, Guo-Gang Xing*. Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis. Science Signaling 2018 Oct 16; 11(552). pii:eaao5150.
(17) Hong-Yan Zhao, Ling-Yu Liu, Jie Cai, Yan-Jun Cui*, Guo-Gang Xing*. Electroacupuncture Treatment Alleviates the Remifentanil-induced Hyperalgesia by Regulating the Activities of Ventral Posterior Lateral Nucleus of the Thalamus Neurons in Rats. Neural Plasticity 2018 Nov 11; 2018:6109723.
(18) Lin Chen#, Song Li#, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu, Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats. Behavioural Brain Research 2018 Feb; 338:134-142.
(19) Xu Ding, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xing*. BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats. Neuropharmacology 2018; 137:114-132.
(20) Ming-Jia Li#, Ling-Yu Liu#, Lin Chen#, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain via the integration of stress-affect related information and nociceptive information in the central nucleus of the amygdala. Pain 2017 Apr;158(4):717-739.
(21) Song Li, Jie Cai, Zhi-Bo Feng, Zi-Run Jin, Bo-Heng Liu, Hong-Yan Zhao, Hong-Bo Jing, Tian-Jiao Wei, Guan-Nan Yang, Ling-Yu Liu, Yan-Jun Cui*, Guo-Gang Xing*. BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDA receptor GluN2B subunit at tyrosine 1472 in rats following spinal nerve ligation. Neurochemical Research 2017 Oct; 42(10): 2712-2729.
(22) Li Li, Qinghai Liu, Long Fan, Wei Xiao, Lei Zhao, Yu Wang, Weiguang Ye, Fei Lan, Bin Jia, Hua Feng, Changman Zhou, Xiuqin Yue, Guo-Gang Xing*, Tianlong Wang*. Protective effects of oxymatrine against arsenic trioxide-induced liver injury. Oncotarget 2017 Feb 21;8(8):12792-12799. Published online 2016 Oct 5. doi: 10.18632/oncotarget.12478.
(23) Yi-Jing Li, Xing-Jie Ping, Chong Qi, Fang Shen, Lin-Lin Sun, Xiao-Wei Sun, Fei-Fei Ge, Guo-Gang Xing and Cai-Lian Cui*. Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation. Addiction Biology 2017 Mar; 22(2):435-445.
(24) Jing Wang, Jing Wang, Guo-Gang Xing, Xiao-Li Li* and You Wan*. Enhanced Gamma Oscillatory Activity in Rats with Chronic Inflammatory Pain. Frontiers in Neuroscience 2016 Nov 1; 10:489. eCollection 2016.
(25) Dong Fang#, Ling-Yu Kong#, Jie Cai#, Song Li, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model. Pain 2015 Jun;156(6):1124-1144.
(26) Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu, Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-Gang Xing, Ming Yi, You Wan*. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. Pain 2015 Apr; 156(4):597-608.
(27) Jie Cai, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren* and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain. Oncology Reports 2015 Mar; 33(3): 1540-1550.
(28) Xu Ding, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease 2015 Jan; 73:428-451. Epub 2014 Nov 8.
(29) Xiao-Dan Liu#, Jing-Jing Yang#, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channels on the Membrane of Dorsal Root Ganglia Neurons Contributes to the Development of Cancer-Induced Bone Pain. PLoS One December 11, 2014, 9(12): e114623.
(30) Hong Jiang#, Dong Fang#, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan* and Guo-Gang Xing*. Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats. Molecular Brain 2014 Oct 4; 7(1):72-93.
(31) Lei Ding#, Jie Cai#, Xiang-Yang Guo, Xiu-Li Meng*, Guo-Gang Xing*. The anti-allodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartate receptors in rats with spared nerve injury. Pain Research & Management 2014; 19(4): 205-211.
(32) Yan Li,Jie Cai, Yin Han, Xin Xiao, Xiang-Lin Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain. European journal of pain 2014; 18(6):774-84.
(33) Fei Yang, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing, You Wan*. The induction of long-term potentiation in spinal dorsal horn after peripheral nociceptive stimulation and contribution of spinal TRPV1 in rats. Neuroscience 2014; 269: 59-66.
(34) Ling Hu, Xiang-Hong Jing, Cai-Lian Cui, Guo-Gang Xing, Bing Zhu*. NMDA receptors in the midbrain play a critical role in dopamine-mediated hippocampal synaptic potentiation caused by morphine. Addiction Biology 2014; 19(3):380-91.
(35) Liu X, Zhang B, Yang H, Wang H, Liu Y, Huang A, Liu T, Tian X, Tong Y, Zhou T, Zhang T, Xing GG, Xiao W, Guo X*, Fan D*, Han X, Liu G*, Zhou Z*, Chui D*. Impaired synaptic vesicle recycling contributes to presynaptic dysfunction in lipoprotein lipase-deficient mice. Neuroscience 2014 Nov 7; 280:275-281.
(36) Min Liu, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, De-Hua Chui, Ji-Sheng Han, Guo-Gang Xing*. Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to the bone cancer pain. Pain 2013; 154(9):1551-1568.
(37) Qin Zheng, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Pain 2013; 154(3): 434-448.
(38) Ya-Nan Wang#, Bo Wang#, Min Liang#, Cai-Yan Han, Bin Zhang, Jie Cai, Wei Sun*, Guo-Gang Xing*. Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, while up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility 2013; 99(2):579-587.
(39) Qin Zheng, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain. Molecular Pain 2012; 8(1):24-41.
(40) Feng-Yu Liu#, Yan-Ni Sun#, Fa-Tian Wang#, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng, Hong Zhao, Xi Wu, Qian Sun, Guo-Gang Xing*, You Wan*. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research 2012; 1427:65-77.
(41) Yi-Lin Song, Nan-Sen Lin, Chun-Xiu Liu, Hong Jiang, Guo-Gang Xing, Xin-Xia Cai*. A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro. Biosensors and Bioelectronics 2012; 38(1):416-20.
(42) Ye-Nan Chi#, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons through NMDA receptors and T-type calcium channels. Neuroscience Bulletin 2012; 28(6):715-22.
(43) Ying Han, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain. Neuroscience Bulletin 2012; 28(2):165-72.
(44) Ying-Ying Wang, Jiong Qin*, Ying Han, Jie Cai, Guo-Gang Xing*. Hyperthermia induces epileptiform discharges in cultured rat cortical neurons. Brain Research 2011; 1417: 87-102.
(45) Ming Yi#, Haolin Zhang#, Lixing Lao, Guo-Gang Xing, You Wan*. Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats. Molecular Pain 2011; 7(1):61.
(46) Jing Wang, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-Gang Xing, Jie Cai and You Wan*. Phase–amplitude coupling between theta and gamma oscillations during nociception in rat electroencephalography. Neuroscience Letters 2011; 499(2):84-87.
(47) Feng-Yu Liu, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-Gang Xing, You Wan*. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation. Neuroscience Bulletin 2011; 27(1):1-8.
(48) Shan-Jing Geng#, Fei-Fei Liao#, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han, You Wan, Guo-Gang Xing*. Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation. Experimental Neurology 2010; 222(2):256-266.
(49) Feng-Yu Liu#, Xiao-Xiu Qu#, Xu Ding#, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research . 2010; 1330:45-60.
(50) Tianran Song, Yue Wang, Guian Chen* and Guogang Xing*. Tyrosine hydroxylase-positive cells and dopaminergic neuronal function in human embryonic stem cells: An electrophysiological validation. Neural Regeneration Research 2010; 5(3):185-190.
(51) Xiao-Xiu Qu#, Jie Cai#, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental Neurology 2009; 215(2):298-307.
(52) Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Molecular Pain 2008; 4(1): 61-70.
(53) Yu-Qiu Jiang, Guo-Gang Xing, Sheng-Lan Wang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan*. Axonal accumulation of hyperpolarization- activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat. Pain 2008; 137(3): 495-506.
(54) Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Role of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat. Brain Research 2008; 1200:19-26.
(55) Hao Luo, Isabella Shi Xu, Yi Chen, Fei Yang, Lu Yu, Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing, Yu-Shun Shi, Tan Li, Ji-Sheng Han and You Wan*. Behavioral and Electrophysiological Evidence for the Differential Functions of TRPV1 at Early and Late Stages of Chronic Inflammatory Nociception in Rats. Neurochemical Research 2008; 33(10):2151-2158.
(56) Guo-Gang Xing*, Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan*. Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain. Experimental Neurology 2007; 208(2):323-332.
(57) Feng-Yu Liu#, Guo-Gang Xing#, Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, You Wan*. Roles of 5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics 2007; 321(3): 1046-1053.
(58) Guo-Gang Xing#, Rengang Wang#, Bo Yang, Dongxian Zhang*. Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. European Journal of Neuroscience 2006; 24(11):2987-2992.
(59) Qian Sun#, Guo-Gang Xing#, Huiyin Tu, Ji-Sheng Han, You Wan*. Inhibition of hyperpolarization- activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain. Brain Research 2005; 1032(1-2): 63-9.
(60) Qian Sun#, Huiyin Tu#, Guo-Gang Xing, Ji-Sheng Han, You Wan*. Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation. Experimental Neurology 2005; 191(1): 128-36.[1]