魏雅檳檢視原始碼討論檢視歷史
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魏雅檳，女，北北京大學中國藥物依賴性研究所副研究員，博士生導師。
研究方向
（4）體外誘導幹細胞、3D腦類胚體模型在神經精神疾病中的應用
教育背景
2005 - 2010 北京大學醫學部 醫學學士
2011 - 2015 Karolinska Institutet 博士
研究經歷
2016 - 2017 Scripps Research Institute 博士後
2017 - 2019 University of California San Diego 博士後
2020 - 現在 北京大學醫學部 副研究員
研究成果
美國試行專利：62/757,686: Method to predict response to neuropsychiatric drugs using variation in the serotonin 7 receptor (HTR7) gene
學術成果
論文
1）Maria Scherma, Johanna S. Qvist, Arun Asok, Shao-shan C. Huang, Paolo Masia, Matteo Deidda, Ya B. Wei, Rajesh K. Soni, Walter Fratta, Paola Fadda, Eric R. Kandel, Denise B. Kandel, and Philippe A. Melas. Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9991-10002.
2）Liu JJ*, Wei YB*, Strawbridge R, Bao Y, Chang S, Shi L, Que J, Gadad BS, Trivedi MH, Kelsoe JR, Lu L. Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis. Mol Psychiatry. 2019 Aug 19. doi: 10.1038/s41380-019-0474-5. *Shared first authorship.
3）Wei YB, McCarthy M, Ren H, Carrillo-Roa T, Shekhtman T, DeModena A, Liu JJ, Leckband S, Mors O, Rietschel M, Henigsberg N, Cattaneo A, Binder EB, Aitchison KJ, Keloe JR. A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. Mol Psychiatry. 2019 Mar 15.
4）Liu JJ, Wei YB, Forsell Y, Lavebratt C. Stress, depressive status and telomere length: Does social interaction and coping strategy play a mediating role? J Affect Disord. 2017 Nov;222:138-145.
5）Wei YB, Liu JJ, Åberg E, Brené S, Wegener G, Mathé AA, Lavebratt C. Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression. Transl Psychiatry. 2016 Aug 16;6:e869.
6）Wei YB, Melas PA, Villaescusa JC, Liu JJ, Xu N, Christiansen SH, Elbrønd-Bek H, Woldbye DP, Wegener G, Mathé AA, Lavebratt C. MicroRNA 101b is downregulated in the prefrontal cortex of a genetic model of depression and targets the glutamate transporter SLC1A1 (EAAT3) in vitro. Int J Neuropsychopharmacol. 2016 Aug 9. pii: pyw069.
7）Wei YB, Martinsson L, Liu JJ, Forsell Y, Schalling M, Backlund L, Lavebratt C. hTERT genetic variation in depression. J Affect Disord. 2015 Sep 16;189:62-69.
8）Wei YB, Backlund L, Wegener G, Mathé AA, Lavebratt C. Telomerase dysregulation in the hippocampus of a rat model of depression. Normalization by lithium. Int J Neuropsychopharmacol. 2015 Jan 24. pii: pyv002. doi: 10.1093/ijnp/pyv002. PMID: 25618407.
9）Wei YB, Melas PA, Wegener G, Mathé AA, Lavebratt C. Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene. Int J Neuropsychopharmacol. 2014 Oct 31;18(2). PMID: 25618518.
10）Martinsson L*, Wei YB*, Xu D, Melas PA, Mathé AA, Schalling M, Lavebratt C, Backlund L. Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres. Transl Psychiatry. 2013 May 21; 3:e261. *Shared first authorship.[1]