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莉薩·安在[[賓夕法尼亞州]]{{Link-en| 伊斯頓 (賓夕法尼亞州)|Easton, Pennsylvania|伊斯頓}} 出世。大約在1990年時，她開始以[[艷舞|跳艷舞]]來支付其大學學費，其後她成為受認可的[[牙醫助理]]<ref name="lisa ann">{{en}}{{cite web | title =Interview with Lisa Ann | publisher =qlimax.com | url =http://qlimax.com/lisa-ann.php | accessdate =2007-12-24 | deadurl =yes | archiveurl =https://web.archive.org/web/20080102053143/http://qlimax.com/lisa-ann.php | archivedate =2008-01-02 }}</ref>。1993年7月，她開始擔任成人演員，但在1997年由於害怕患上[[愛滋病]]而離開<ref name="lisa ann"/>。接著的數年，她在全美國的[[脫衣舞俱樂部]]演出並順道旅遊，後來他重返色情業擔任代理人，後來又參與演出<ref name="lisa ann"/><ref>{{en}}{{cite web |url=http://business.avn.com/articles/23219.html |title=Lisa Ann Becomes Agent for LA Direct |publisher=business.avn.com |accessdate=2010-03-17|date=2005-09-21 }}</ref><ref>{{en}}{{cite web |url=http://business.avn.com/articles/25398.html |title=AVN - Lisa Ann Leaves Agenting to Return to Performing |publisher=business.avn.com |accessdate=2010-03-17|date=2006-02-16 }}</ref>。她的[[人才機構]]—清析人才管理（Clear Talent Management）在2006年11月成立<ref name="lisa ann"/>，後來改名為莉薩·安人才管理（Lisa Ann's Talent Management）<ref>{{en}}{{cite web|url=http://business.avn.com/articles/8457.html |title=Lisa Ann Renames Talent Agency |publisher=business.avn.com |accessdate=2010-03-17 |author=David Sullivan |date=2007-06-01 |deadurl=yes |archiveurl=https://web.archive.org/web/20100107055859/http://business.avn.com/articles/8457.html |archivedate=2010-01-07 }}</ref>。2007年，莉薩·安人才管理與{{Link-en|西莫爾·巴茨|Seymore Butts}}的燈塔機構（Lighthouse Agency.）合併<ref>{{en}}{{cite web|url=http://business.avn.com/articles/5464.html |title=Lighthouse Talent Merges with Lisa Ann’s Talent Management |publisher=business.avn.com |accessdate=2010-03-17 |author=Eddie Adams |date=2007-12-11 |deadurl=yes |archiveurl=https://web.archive.org/web/20100107055753/http://business.avn.com/articles/5464.html |archivedate=2010-01-07 }}</ref><ref name=XRent>{{en}}{{cite web |url=http://www.xrentdvd.com/Porn_Star_Interviews/Lisa_Ann.html |title= Inside Lisa Ann|publisher=www.xrentdvd.com |accessdate=2010-05-13|date= 2010-04-02|author= Big D}}</ref>。