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松阳洲
原图链接 来自搜狗网
国籍 中国
职业 教授、科学家

松阳洲，男，中山大学生命科学学院院长，教授，博士导师。 美国Baylor医学院生化和分子生物学系终身教授，分子药物研发主任，RNAi 中心主任，Huffington 衰老和细胞分子生物学中心，干细胞和新生医学中心及Dan L. Duncan肿瘤中心研究员。在过去的十多年，松阳教授在分子细胞学领域的研究中做出了独创性的贡献。他对人体细胞端粒调节机理和胚胎干细胞的蛋白组学和功能性的研究处于国内外相关领域的前沿。[1]

研究方向

干细胞生长与分化， 肿瘤生长和人体衰老机制; 细胞端粒的结构、端粒蛋白的功能与作用机理，信号传导网络，DNA 损伤与修复，蛋白质间相互作用以及功能基因的高通量筛选和鉴定。

简历

  • 1990年获广州中山大学生物化学理学学士学位。
  • 2004年晋升为终身副教授。
  • 2008年晋升为生化和分子生物学系终身教授。同时担任贝勒医学院药学系教授，高通量实验中心主任，兼Huffington衰老和细胞分子生物学中心，干细胞和新生医学中心及D.L. Duncan肿瘤中心研究员。
  • 2009年就任中山大学生命科学学院院长。

已发表论文和论著达80篇，在Nature, Science, Cell, PNAS, Nature Cell Biology, NSMB, Molecular Cell等影响因子大于10的期刊上发表论文逾20篇;总引用次数超过7500次。

新闻报导

遗传性疾病、癌症、艾滋病、地中海贫血，将来有没有可能得到根治？国家首批“千人计划”特聘专家、中山大学生命科学学院松阳洲教授团队近日在接受新华社记者专访时作出了肯定的回答，并认为基因编辑技术将让人类获得“改写生命剧本的神笔”，为战胜疾病提供全新的有效工具。[2]

“那是一把特异剪切基因的‘剪刀’。”松阳洲在接受采访时说。中山大学人类胚胎遗传性致病基因修复实验采取了CRISPR/Cas9基因编辑技术。该技术是近年在锌指核酸酶（ZFN）技术、类转录激活样效应因子核酸酶（TALEN）技术之后出现的新型基因编辑技术，原理来自细菌的适应性免疫防御机制。相比传统的基因打靶技术和其他基因编辑技术，CRISPR/Cas9更为精确、高效和经济。

“目前人类对很多致命疾病的药物治疗都只是在抑制病变、延缓恶化。未来，基因编辑技术将改变这一局面，为人类找到战胜疾病的全新路径。”松阳洲说。

松阳洲认为，人类发现自身奥秘的征程漫长。这一进程必须被合理、严格地加以管理、控制，既要防止因噎废食导致科学停滞不前，又要防止经修改的基因成为人类基因库中的一员，打开人为改变人类进化进程的“潘多拉魔盒”。[3]

​​原图链接 来自新乡网

　松阳洲教授团队主要成员松阳洲（左）、马文宾（中）、黄军就在实验里

荣誉

曾荣获Scientist报年度最佳论文奖和Cell杂志30年最佳30篇文章奖，Irvington Institute Postdoctoral Fellowship, Ellison New Scholar，American Cancer Society Scholar与Leukemia and Lymphoma Society Scholar等荣誉。担任Science, Nature, Cell, PNAS和JBC等国际刊物的审稿人。

代表性的论文

(选自70多篇SCI文章)

  • 1. Songyang, Z., Shoelson, SE, Chadhuri, M., Gish, G., Pawson, T., Haser, WG, King, F., Roberts, T., Ratnofsky, S., Lechleider, RJ, Neel, BG, Birge, RB, Fajardo JE, Chou, MM, Hanafusa, H., Schaffhausen, B. and Cantley, LC (1993) SH2 Domains Recognize Specific Phosphopeptide Sequences. Cell 72, 767-778. (Cell杂志30年最佳30篇文章之一)
  • 2. Ravichandran KS, Lee KK, Songyang Z., Cantley LC, Burn P, Burakoff SJ (1993) Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science. 262:902-5.
  • 3. Songyang, Z., Shoelson, SE, McGlade, Olivier, JP, Pawson, T., Bustelo, XR, Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, RA, and Cantley, LC (1994) Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, SHPTP1, SHC, Syk and Vav. Mol. Cell. Biol.14, 2777-2785. (Scientist报年度最佳论文奖)
  • 4. Marengere, LE, Songyang, Z., Gish, GD, Schaller, MD, Parsons, JT, Stern, MJ, Cantley, LC, and Pawson, T. (1994) SH2 domain specificity and activity modified by a single residue. Nature 369, 502-505.
  • 5. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., Cantley, L. C. (1994) Use of an oriented peptide library technique for determining the optimal substrates of protein kinases. Curr. Biol. 4, 973-982.
  • 6. Songyang, Z., Carraway, KL III, Eck, MJ, Harrison, SC, Feldman, RA, Mohammodi, M., Schlessinger, J., Hubbard, S., Smith, DP, Eng, C., Lorenzo, M. J., Ponder, BAJ., Mayer, BJ, and Cantley, LC (1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signaling. Nature 373, 536-539.
  • 7. Songyang, Z., Lu, KP, Kwon, YT, Tsai, LH, Filhol, O., Cochet, C., Brickey, D. A., Soderling, TR, Bartleson, C., Graves, DJ, DeMaggio, AJ, Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, LC (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16, 6486-6493.
  • 8. Songyang, Z., Fanning, AS, Fu, C., Xu, J., Marfatia, SM, Chishti, AH, Crompton, A., Chan, AC, Anderson, JM, and Cantley, LC (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.
  • 9. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R., and Franke, T. F. (1997) Interleukin 3-dependent survival by the Akt protein kinase. PNAS 94, 11345-11350.
  • 10. Liu, D., Yang, X. H., and Songyang, Z. (2000) Identification of CISK, a new member of the SGK kinase family that promotes IL-3 dependent survival. Curr. Biol. 10, 1233-36.
  • 11. Liu, D., Yang, X. H., Yang, D. L., and Songyang, Z. (2000) Genetic screens in mammalian cells using Enhanced Retroviral Mutagens. Oncogene, 19, 5964-72.
  • 12. Songyang, Z., Yamanashi ,Y., Liu, D., and Baltimore, D. (2001) Domain-dependent function of p62Dok in cell signaling. J. Biol. Chem. 276, 2459-65.
  • 13. Xu, J., Liu, D., Gill, G., and Songyang, Z. (2001) Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J. Cell. Biol. 154, 699-706
  • 14. Xu, J., Liu, D., Songyang, Z. (2002) The role of asp-462 in regulating akt activity. J Biol Chem. 277:35561-6.
  • 15. Rodriguez M, Yu X, Chen J, and Songyang Z. (2003) Phosphopeptide binding specificities of BRCT domains. J Biol Chem. 278: 52914-8.
  • 16. Rodriguez M, Li, SC, Harper JW, and Songyang Z. (2004) An oriented peptide array library (OPAL) strategy to study protein-protein interactions. J Biol Chem. 279:8802-7.
  • 17. Songyang Z. and Cantley LC (2004) ZIP codes for delivering SH2 domains. Cell. 116:S41-3.
  • 18. OConnor MS, Safari A, Liu D, Qin J, and Songyang Z. (2004) The human Rap1 protein complex and modulation of telomere length. J Biol. Chem. 279(27):28585-91.
  • 19. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z. (2004) PTOP interacts with POT1 and regulates POT1 telomeric localization. Nature Cell Biol. 6(7):673-80.
  • 20. Liu D, O'Connor MS, Qin J, Songyang Z. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol. Chem. 279:51338-42.
  • 21. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. PNAS. 103:11874-9.
  • 22. Xin H, Liu D, Safari A, Wan M., Sun W, Kim H, O'Connor MW, and Songyang Z. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature45, 559-62.
  • 23. Chen L., D. Liu, and Songyang Z. (2007) Telomere maintenance through spatial control of telomeric proteins. Mol. Cell Biol. 27: 5898-909.
  • 24. Liang JC, Ma W., Zhang Y., Gu P., Xin H., Jung SY, Qin J., Wong J., Cooney A., Liu D., and Songyang Z. (2008) Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nature Cell Biol. 10:731-9.
  • 25. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z., Thomson JA, Zwaka TP. (2008) Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133:1162-74.
  • 26. Kim H., LeeOH, XinH., ChenLY, QinJ., ChaeHK, LinSY, SafariA., LiuD., and Songyang Z. (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nature Struc. Mol. Biol. 16: 372-379.

参考文献

  1. ↑ 松阳洲的介绍 搜狗网 2018-09-13
  2. ↑ 人类获得“改写生命剧本的神笔” 新乡网 2016-04-08
  3. ↑ 基因编辑技术：为战胜疾病提供全新有效工具 中国制药网 2016-04-10
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