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松陽洲檢視原始碼討論檢視歷史

事實揭露 揭密真相
前往： 導覽、 搜尋
松陽洲
原圖鏈接 來自搜狗網
國籍 中國
職業 教授、科學家

松陽洲，男，中山大學生命科學學院院長，教授，博士導師。 美國Baylor醫學院生化和分子生物學系終身教授，分子藥物研發主任，RNAi 中心主任，Huffington 衰老和細胞分子生物學中心，幹細胞和新生醫學中心及Dan L. Duncan腫瘤中心研究員。在過去的十多年，松陽教授在分子細胞學領域的研究中做出了獨創性的貢獻。他對人體細胞端粒調節機理和胚胎幹細胞的蛋白組學和功能性的研究處於國內外相關領域的前沿。[1]

研究方向

幹細胞生長與分化， 腫瘤生長和人體衰老機制; 細胞端粒的結構、端粒蛋白的功能與作用機理，信號傳導網絡，DNA 損傷與修復，蛋白質間相互作用以及功能基因的高通量篩選和鑑定。

簡歷

  • 1990年獲廣州中山大學生物化學理學學士學位。
  • 2004年晉升為終身副教授。
  • 2008年晉升為生化和分子生物學系終身教授。同時擔任貝勒醫學院藥學系教授，高通量實驗中心主任，兼Huffington衰老和細胞分子生物學中心，幹細胞和新生醫學中心及D.L. Duncan腫瘤中心研究員。
  • 2009年就任中山大學生命科學學院院長。

已發表論文和論著達80篇，在Nature, Science, Cell, PNAS, Nature Cell Biology, NSMB, Molecular Cell等影響因子大於10的期刊上發表論文逾20篇;總引用次數超過7500次。

新聞報導

遺傳性疾病、癌症、艾滋病、地中海貧血，將來有沒有可能得到根治？國家首批「千人計劃」特聘專家、中山大學生命科學學院松陽洲教授團隊近日在接受新華社記者專訪時作出了肯定的回答，並認為基因編輯技術將讓人類獲得「改寫生命劇本的神筆」，為戰勝疾病提供全新的有效工具。[2]

「那是一把特異剪切基因的『剪刀』。」松陽洲在接受採訪時說。中山大學人類胚胎遺傳性致病基因修復實驗採取了CRISPR/Cas9基因編輯技術。該技術是近年在鋅指核酸酶（ZFN）技術、類轉錄激活樣效應因子核酸酶（TALEN）技術之後出現的新型基因編輯技術，原理來自細菌的適應性免疫防禦機制。相比傳統的基因打靶技術和其他基因編輯技術，CRISPR/Cas9更為精確、高效和經濟。

「目前人類對很多致命疾病的藥物治療都只是在抑制病變、延緩惡化。未來，基因編輯技術將改變這一局面，為人類找到戰勝疾病的全新路徑。」松陽洲說。

松陽洲認為，人類發現自身奧秘的征程漫長。這一進程必須被合理、嚴格地加以管理、控制，既要防止因噎廢食導致科學停滯不前，又要防止經修改的基因成為人類基因庫中的一員，打開人為改變人類進化進程的「潘多拉魔盒」。[3]

​​原圖鏈接 來自新鄉網

　松陽洲教授團隊主要成員松陽洲（左）、馬文賓（中）、黃軍就在實驗裡

榮譽

曾榮獲Scientist報年度最佳論文獎和Cell雜誌30年最佳30篇文章獎，Irvington Institute Postdoctoral Fellowship, Ellison New Scholar，American Cancer Society Scholar與Leukemia and Lymphoma Society Scholar等榮譽。擔任Science, Nature, Cell, PNAS和JBC等國際刊物的審稿人。

代表性的論文

(選自70多篇SCI文章)

  • 1. Songyang, Z., Shoelson, SE, Chadhuri, M., Gish, G., Pawson, T., Haser, WG, King, F., Roberts, T., Ratnofsky, S., Lechleider, RJ, Neel, BG, Birge, RB, Fajardo JE, Chou, MM, Hanafusa, H., Schaffhausen, B. and Cantley, LC (1993) SH2 Domains Recognize Specific Phosphopeptide Sequences. Cell 72, 767-778. (Cell雜誌30年最佳30篇文章之一)
  • 2. Ravichandran KS, Lee KK, Songyang Z., Cantley LC, Burn P, Burakoff SJ (1993) Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science. 262:902-5.
  • 3. Songyang, Z., Shoelson, SE, McGlade, Olivier, JP, Pawson, T., Bustelo, XR, Barbacid, M., Sabe, H., Hanafusa, H., Yi, T., Ren, R., Baltimore, D., Ratnofsky, S., Feldman, RA, and Cantley, LC (1994) Specific Motifs Recognized by the SH2 Domains of Csk, 3BP2, fps/fes, GRB-2, SHPTP1, SHC, Syk and Vav. Mol. Cell. Biol.14, 2777-2785. (Scientist報年度最佳論文獎)
  • 4. Marengere, LE, Songyang, Z., Gish, GD, Schaller, MD, Parsons, JT, Stern, MJ, Cantley, LC, and Pawson, T. (1994) SH2 domain specificity and activity modified by a single residue. Nature 369, 502-505.
  • 5. Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M. F., Piwnica-Worms, H., Cantley, L. C. (1994) Use of an oriented peptide library technique for determining the optimal substrates of protein kinases. Curr. Biol. 4, 973-982.
  • 6. Songyang, Z., Carraway, KL III, Eck, MJ, Harrison, SC, Feldman, RA, Mohammodi, M., Schlessinger, J., Hubbard, S., Smith, DP, Eng, C., Lorenzo, M. J., Ponder, BAJ., Mayer, BJ, and Cantley, LC (1995) Catalytic specificity of protein-tyrosine kinases is critical for selective signaling. Nature 373, 536-539.
  • 7. Songyang, Z., Lu, KP, Kwon, YT, Tsai, LH, Filhol, O., Cochet, C., Brickey, D. A., Soderling, TR, Bartleson, C., Graves, DJ, DeMaggio, AJ, Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, LC (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16, 6486-6493.
  • 8. Songyang, Z., Fanning, AS, Fu, C., Xu, J., Marfatia, SM, Chishti, AH, Crompton, A., Chan, AC, Anderson, JM, and Cantley, LC (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.
  • 9. Songyang, Z., Baltimore, D., Cantley, L. C., Kaplan, D. R., and Franke, T. F. (1997) Interleukin 3-dependent survival by the Akt protein kinase. PNAS 94, 11345-11350.
  • 10. Liu, D., Yang, X. H., and Songyang, Z. (2000) Identification of CISK, a new member of the SGK kinase family that promotes IL-3 dependent survival. Curr. Biol. 10, 1233-36.
  • 11. Liu, D., Yang, X. H., Yang, D. L., and Songyang, Z. (2000) Genetic screens in mammalian cells using Enhanced Retroviral Mutagens. Oncogene, 19, 5964-72.
  • 12. Songyang, Z., Yamanashi ,Y., Liu, D., and Baltimore, D. (2001) Domain-dependent function of p62Dok in cell signaling. J. Biol. Chem. 276, 2459-65.
  • 13. Xu, J., Liu, D., Gill, G., and Songyang, Z. (2001) Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J. Cell. Biol. 154, 699-706
  • 14. Xu, J., Liu, D., Songyang, Z. (2002) The role of asp-462 in regulating akt activity. J Biol Chem. 277:35561-6.
  • 15. Rodriguez M, Yu X, Chen J, and Songyang Z. (2003) Phosphopeptide binding specificities of BRCT domains. J Biol Chem. 278: 52914-8.
  • 16. Rodriguez M, Li, SC, Harper JW, and Songyang Z. (2004) An oriented peptide array library (OPAL) strategy to study protein-protein interactions. J Biol Chem. 279:8802-7.
  • 17. Songyang Z. and Cantley LC (2004) ZIP codes for delivering SH2 domains. Cell. 116:S41-3.
  • 18. OConnor MS, Safari A, Liu D, Qin J, and Songyang Z. (2004) The human Rap1 protein complex and modulation of telomere length. J Biol. Chem. 279(27):28585-91.
  • 19. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z. (2004) PTOP interacts with POT1 and regulates POT1 telomeric localization. Nature Cell Biol. 6(7):673-80.
  • 20. Liu D, O'Connor MS, Qin J, Songyang Z. (2004) Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol. Chem. 279:51338-42.
  • 21. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. PNAS. 103:11874-9.
  • 22. Xin H, Liu D, Safari A, Wan M., Sun W, Kim H, O'Connor MW, and Songyang Z. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature45, 559-62.
  • 23. Chen L., D. Liu, and Songyang Z. (2007) Telomere maintenance through spatial control of telomeric proteins. Mol. Cell Biol. 27: 5898-909.
  • 24. Liang JC, Ma W., Zhang Y., Gu P., Xin H., Jung SY, Qin J., Wong J., Cooney A., Liu D., and Songyang Z. (2008) Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nature Cell Biol. 10:731-9.
  • 25. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z., Thomson JA, Zwaka TP. (2008) Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 133:1162-74.
  • 26. Kim H., LeeOH, XinH., ChenLY, QinJ., ChaeHK, LinSY, SafariA., LiuD., and Songyang Z. (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nature Struc. Mol. Biol. 16: 372-379.

參考文獻

  1. ↑ 松陽洲的介紹 搜狗網 2018-09-13
  2. ↑ 人類獲得「改寫生命劇本的神筆」 新鄉網 2016-04-08
  3. ↑ 基因編輯技術：為戰勝疾病提供全新有效工具 中國製藥網 2016-04-10
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