李川昀檢視原始碼討論檢視歷史
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李川昀，男，北京大學未來技術學院教授。
人物履歷
教育背景
1999-2003 北京理工大學生命科學學院 本科
2007.9 – 2008.10 美國國立醫學研究中心（NIH）交換學生 導師：George Uhl
2004.9-2009.2 北京大學生命科學學院 博士 導師：魏麗萍
工作簡歷
2009.3 –2010.12 北京大學生命科學學院 博士後
2011.1 –2019.7 北京大學分子醫學研究所 研究員
2019.8 –現在 北京大學未來技術學院分子醫學研究所 教授
研究領域
開展人類演化與腦科學研究。近年來將前沿的生物信息學方法、分子演化理論和多組學研究策略引入非人靈長類領域，在探究人類特有基因與調控的起源與功能，揭示人腦演化規律、發現重大疾病新靶點等方面取得系列成果。
獲獎情況
入選中組部「萬人計劃」青年拔尖人才, 獲國家「優秀青年科學基金」等支持，獲「貝時璋青年生物物理學家獎」等獎項，指導的博士生獲「吳瑞獎」等。
社會任職
擔任中國動物學會靈長類學分會理事、中國實驗動物學會靈長類專業委員會常務委員等。
所授課程
本科生/研究生：
《基因組醫學基礎》（選修，2學分，獲北京大學教學優秀獎）
《高級基因組醫學》（選修，3學分）
承擔項目
n 北京腦科學與類腦研究中心科研合作項目，人類特有調控在人腦發育中的功能探究，2021/01-2023/12
n 國家重點研發計劃，2019YFA0801800，遠程器官與骨髓的代謝特徵及對話基礎，2019/12-2024/11，
n 國家重點研發計劃，2018YFA0801405，發育、代謝複雜疾病靈長類動物模型的創製與臨床前研究，2019/11-2024/10
n 國家自然科學基金，31871272，基於全長轉錄譜的人類、恆河猴比較基因組學研究，2019/01-2022/12
學術成果
論文
1. Li Yumei#, Shen Qing S#, Peng Qi#, Ding Wanqiu, Zhang Jie, Zhong Xiaoming, An Ni A, Ji Mingjun, Zhou Wei-Zhen, Li Chuan-Yun*; Polyadenylation-related isoform switching in human evolution revealed by full-length transcript structure, Briefings in Bioinformatics, 2021, bbab157
2. Shao Li Wa#; Peng Qi#; Dong Mingyue; Gao Kaiyu; Li Yumei; Li Yi; Li Chuan Yun*; Liu Ying*; Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity, Nature Communications, 2020, 11(1): 0-4639.
3. An Ni A#; Ding Wanqiu#; Yang Xin Zhuang#; Peng Jiguang; He Bin Z; Shen Qing S; Lu Fujian; He Aibin; Zhang Yong E; Tan Bertrand Chin Ming; Chen Jia Yu*; Li Chuan Yun*; Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates, Genome Biology, 2019, 20(1):0-24.
4. Li Yumei#; Ai Shanshan#; Yu Xianhong#; Li Chen; Li Xin; Yue Yanzhu; Wei Yusheng; Li Chuan Yun*; He Aibin*; Replication-Independent Histone Turnover Underlines the Epigenetic Homeostasis in Adult Heart, Circulation Research, 2019, 125(2): 198-208.
5. Li Yumei#; Li Chen#; Li Shuxian; Peng Qi; An Ni A; He Aibin*; Li Chuan Yun*; Human exonization through differential nucleosome occupancy, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(35): 8817-8822.
6. Xiao Yao#; Wang Can#; Chen Jia Yu; Lu Fujian; Wang Jue; Hou Ning; Hu Xiaomin; Zeng Fanxin; Ma Dongwei; Sun Xueting; Ding Yi; Zhang Yan; Zheng Wen; Liu Yuli; Shang Haibao; Zhu Wenzhen; Han Chensheng; Zhang Yulin; Ouyang Kunfu; Chen Liangyi; Chen Ju; Xiao Rui Ping; Li Chuan Yun*; Zhang Xiuqin*; Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders, Nature Communications, 2018, 9(1): 0-2015.
7. Zhang Shi Jian#; Wang Chenqu#; Yan Shouyu; Fu Aisi; Luan Xuke; Li Yumei; Shen Qing S; Zhong Xiaoming; Chen Jia Yu; Wang Xiangfeng; Tan Bertrand Chin Ming; He Aibin; Li Chuan Yun*; Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events, Molecular Biology and Evolution, 2017, 34(10): 2453-2468.
8. Lei Lei#; Yan Shou Yu#; Yang Ran; Chen Jia Yu; Li Yumei; Bu Ye; Chang Nannan; Zhou Qinchao; Zhu Xiaojun; Li Chuan Yun*; Xiong Jing Wei*; Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors, Nucleic Acids Research, 2017, 45(6): 3422-3436.
9. Zhong Xiaoming#; Peng Jiguang#; Shen Qing S#; Chen Jia Yu; Gao Han; Luan Xuke; Yan Shouyu; Huang Xin; Zhang Shi Jian; Xu Luying; Zhang Xiuqin; Tan Bertrand Chin Ming; Li Chuan Yun*; RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque, Molecular Biology and Evolution, 2016, 33(5): 1370-5.
10. Yang Xin Zhuang#; Chen Jia Yu#; Liu Chu Jun; Peng Jiguang; Wee Yin Rei; Han Xiaorui; Wang Chenqu; Zhong Xiaoming; Shen Qing S; Liu Hsuan; Cao Huiqing; Chen Xiao Wei; Tan Bertrand Chin-Ming*; Li Chuan Yun*; Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates, Molecular Biology and Evolution, 2015, 32(12): 3143-3157.
11. Chen Jia Yu#; Shen Qing S#; Zhou Wei Zhen#; Peng Jiguang; He Bin Z; Li Yumei; Liu Chu Jun; Luan Xuke; Ding Wanqiu; Li Shuxian; Chen Chunyan; Tan Bertrand Chin Ming; Zhang Yong E; He Aibin*; Li Chuan-Yun*; Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates, PLoS Genetics, 2015, 11(7).
12. Zhang Shi Jian#; Liu Chu Jun#; Yu Peng#; Zhong Xiaoming; Chen Jia Yu; Yang Xin Zhuang; Peng Jiguang; Yan Shouyu; Wang Chenqu; Zhu Xiaotong; Xiong Jingwei; Zhang Yong E; Tan Bertrand Chin Ming; Li Chuan Yun*; Evolutionary Interrogation of Human Biology in Well-annotated Genomic Framework of Rhesus Macaque, Molecular Biology and Evolution, 2014, 31(5): 1309-1324.
13. Chen Jia Yu#; Peng Zhiyu#; Zhang Rongli#; Yang Xin Zhuang; Tan Bertrand Chin Ming; Fang Huaying; Liu Chu Jun; Shi Mingming; Ye Zhi Qiang; Zhang Yong E; Deng Minghua; Zhang Xiuqin*; Li Chuan Yun*; RNA Editome in Rhesus Macaque Shaped by Purifying Selection, PLoS Genetics, 2014, 10(4).
14. Zhang Shi Jian#; Liu Chu Jun#; Shi Mingming#; Kong Lei; Chen Jia Yu; Zhou Wei Zhen; Zhu Xiaotong; Yu Peng; Wang Jue; Yang Xin Zhuang; Hou Ning.; Ye Zhiqiang; Zhang Rongli; Xiao Ruiping; Zhang Xiuqin*; Li Chuan Yun*; RhesusBase: a knowledgebase for the monkey research community, Nucleic Acids Research, 2013, 41(D1): 892-905.
15. Xie Chen#; Zhang Yong#; Chen Jia Yu#; Liu Chu Jun; Zhou Wei Zhen; Li Ying; Zhang Mao; Zhang Rongli; Wei Liping*; Li Chuan Yun*; Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs, PLoS Genetics, 2012, 8(9).[1]